INT174552

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.29
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tyrobp)
Anatomy Link Frequency
T cells 3
osteoclast 2
lymphocytes 1
Tyrobp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 93.68 High High
rheumatoid arthritis 121 89.72 High High
tolerance 22 75.84 Quite High
Inflammation 26 72.64 Quite High
psoriasis 2 64.96 Quite High
Arthritis 8 50.00 Quite Low
Angina 2 45.08 Quite Low
Inflammatory response 4 29.48 Quite Low
withdrawal 13 24.72 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 20 99.80 Very High Very High Very High
Autoimmune Disease 48 91.48 High High
Rheumatoid Arthritis 121 89.72 High High
Rupture 6 84.08 Quite High
Targeted Disruption 9 76.00 Quite High
Osteopetrosis 18 73.44 Quite High
INFLAMMATION 30 72.64 Quite High
Disease 61 71.60 Quite High
Psoriasis 2 64.96 Quite High
Myocardial Infarction 4 56.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteoclasts are present in Dap12-deficient mouse bones but are poorly functional, whereas in vitro, they cannot be differentiated in the presence of MCSF and RANKL, the two osteoclastogenic cytokines.
Gene_expression (present) of Dap12 in Osteoclasts associated with cytokine
1) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0.05
Differences between osteoclastogenesis in vivo and in vitro in humans and in mice, as well as co-culture experiments, suggest that other co-stimulatory signals are present in Dap12-deficient mice to allow osteoclast differentiation.
Gene_expression (present) of Dap12 in osteoclast
2) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.21 Pain Relevance 0
Absence of mature lymphocytes increases bone mass only in the absence of a functional DAP12 protein
Neg (absence) Gene_expression (absence) of DAP12 protein in lymphocytes
3) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
An adapter molecule conferring full stimulatory function is DAP12, which expresses an ITAM motif [78].
Gene_expression (expresses) of DAP12
4) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.09 Pain Relevance 0
In contrast, stimulatory KIR receptors provide co-stimulatory signals in T cells that lack the expression of DAP12 [80].
Gene_expression (expression) of DAP12 in T cells
5) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.35 Pain Relevance 0.10
The coexpression of DAP12 and the stimulatory receptor encoded by the KIR2DS2 gene is sufficient to form an independent antigen recognition unit that confers the ability to fully activate a T cell, even in the absence of TCR triggering.
Gene_expression (coexpression) of DAP12 in T cell
6) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.85 Pain Relevance 0.14
Most interestingly, T cells in patients with ACS can also express the adaptor molecule, DAP12.
Gene_expression (express) of DAP12 in T cells associated with acute coronary syndrome
7) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.80 Pain Relevance 0.14

General Comments

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