INT174553

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.62
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
nucleus 4
lung 2
macrophages 1
blood 1
fibroblasts 1
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 137 99.98 Very High Very High Very High
ketamine 11 88.84 High High
psoriasis 92 81.60 Quite High
Angina 1 73.40 Quite High
Inflammation 126 72.48 Quite High
rheumatoid arthritis 45 65.92 Quite High
Inflammatory response 12 57.80 Quite High
Central nervous system 22 55.60 Quite High
Arthritis 12 50.00 Quite Low
metalloproteinase 6 45.92 Quite Low
Disease Link Frequency Relevance Heat
Cancer 905 99.52 Very High Very High Very High
Breast Cancer 54 99.52 Very High Very High Very High
Targeted Disruption 51 99.20 Very High Very High Very High
Acute Coronary Syndrome 10 98.94 Very High Very High Very High
Viral Infection 16 97.90 Very High Very High Very High
Metastasis 171 94.16 High High
Dna Damage 90 87.96 High High
Autoimmune Disease 13 86.80 High High
Myocardial Infarction 3 84.36 Quite High
Psoriasis 103 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This transduction involves activation of Type I and Type II IFN receptors, receptor-associated JAK/TYK (tyrosine kinase) kinases and eventually activation and nuclear translocation of STAT1.
Localization (translocation) of STAT1
1) Confidence 0.80 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.13 Pain Relevance 0
STAT1 is phosphorylated by JAK1/2 kinases at the Tyr701 position and then translocates to the nucleus where it binds to GAS (IFN?
Localization (translocates) of STAT1 in nucleus
2) Confidence 0.80 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.70 Pain Relevance 0.08
Quantification of IFN/STAT1 pathway expression and definition of STAT1H and STAT1L genotype
Localization (genotype) of STAT1H
3) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.07 Pain Relevance 0
Quantification of IFN/STAT1 pathway expression and definition of STAT1H and STAT1L genotype
Localization (genotype) of STAT1L
4) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.07 Pain Relevance 0
A striking observation was that after only the first passage (P1), established cell lines obtained from the lung colonies clearly segregated into the STAT1H and STAT1L genotypes (Figure 1D).
Localization (segregated) of STAT1L in lung
5) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.25 Pain Relevance 0
Selection of cell lines from IFN/STAT1-expressing tumor colonies
Localization (Selection) of STAT1 associated with cancer
6) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.37 Pain Relevance 0.04
A striking observation was that after only the first passage (P1), established cell lines obtained from the lung colonies clearly segregated into the STAT1H and STAT1L genotypes (Figure 1D).
Localization (segregated) of STAT1H in lung
7) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.25 Pain Relevance 0
These observations lead us to hypothesize that the development of tumor clones overexpressing the IFN/STAT1 pathway is associated with selection against IFNs, and perhaps other STAT1-activating ligands, secreted by the host microenvironment leading to the selection of cells resistant to the cytotoxic effects of transient STAT1 activation.
Localization (secreted) of STAT1 associated with cancer
8) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.77 Pain Relevance 0
Indeed, in an ex vivo co-culture model it was demonstrated that stromal fibroblasts can secrete IFNs, activating the IFN/STAT1 pathway in breast cancer cells, and that this pathway is associated with poor prognosis in patients with breast cancer due to the development of metastases [48].
Localization (secrete) of STAT1 in fibroblasts associated with breast cancer and metastasis
9) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.67 Pain Relevance 0
-inducible genes are upregulated in the peripheral blood of patients with ACS, and circulating monocytes show evidence of nuclear translocation of STAT-1 homodimers, indicative of IFN-?
Localization (translocation) of STAT-1 in blood associated with acute coronary syndrome
10) Confidence 0.68 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 1.39 Pain Relevance 0.20
Since within seconds after phosphorylation STAT1 translocates into the nucleus for binding to the DNA of its target genes [31], we determined the levels of pSTAT1 in the nuclear fractions of the PEO treated cells.
Localization (translocates) of STAT1 in nucleus
11) Confidence 0.61 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.28 Pain Relevance 0.04
Figure 4 depicts results for the validation of Cd44, Stat1, Ch25h, Il1b, C1qa and Hexb.
Localization (validation) of Stat1
12) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.06 Pain Relevance 0.03
Cytokine group (12 transcripts mRNAs): CCL2, IL1B, IL6, CSF2, CSF3, IFNG, IRAK1, IRAK2, NLRP2, KAT2B, STAT1, and EGR1 (All abbreviations are current Entrez Gene official symbols and official full names are presented in Table S1).
Localization (group) of STAT1 associated with cytokine
13) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.20 Pain Relevance 0.11
Thus, Sp1 or STAT1 was immunoprecipitated from extracts of J774.2 macrophages that had either been left untreated or stimulated with IFN-?
Localization (immunoprecipitated) of STAT1 in macrophages
14) Confidence 0.40 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03
R1-STAT1 complex seems to be internalized and translocated to the nucleus, where the activated STAT1 homodimer binds to DNA at GAS elements and induces the first wave of responses [204,207-211].
Localization (translocated) of STAT1 in nucleus
15) Confidence 0.33 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.07 Pain Relevance 0.12
-JAK/Stat signaling pathway is critical for host defense against viral infection by stimulating transcription of antiviral, antiproliferative, and antitumor genes, suggesting that down-regulation of IFNAR2 and Stat-1 in skin from K14E6 transgenic mice might be critical for immune evasion and therefore for cancer development.
Localization (regulation) of Stat-1 in skin associated with targeted disruption, cancer and viral infection
16) Confidence 0.23 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.99 Pain Relevance 0
1 and IL-23R chain are associated with intracellular proteins of the Janus kinase (Jak) family to induce downstream signaling, resulting in a sequence of phosphorylation processes activating signal transducer and activator of transcription (STAT) molecules, namely STAT1, STAT3, STAT4, and STAT5, which translocate into the nucleus where they bind DNA in the promoter region of target genes.24
Localization (translocate) of STAT1 in nucleus
17) Confidence 0.21 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.33 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox