INT174556

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.90
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Link Frequency
T cells 4
Cd28 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 199 98.84 Very High Very High Very High
Inflammation 75 98.64 Very High Very High Very High
Infliximab 4 96.88 Very High Very High Very High
cva 2 83.76 Quite High
cytokine 10 74.32 Quite High
Arthritis 16 50.00 Quite Low
tolerance 24 18.32 Low Low
spinal inflammation 13 5.00 Very Low Very Low Very Low
Osteoarthritis 9 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 200 98.84 Very High Very High Very High
INFLAMMATION 82 98.64 Very High Very High Very High
Cardiovascular Disease 80 94.12 High High
Necrosis 7 94.08 High High
Increased Venous Pressure Under Development 5 93.80 High High
Cancer 7 93.72 High High
Aging 36 92.52 High High
Cv General 3 Under Development 5 83.76 Quite High
Disease 56 64.80 Quite High
Death 11 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concept of modulation of such pathomechanisms by potent anti-inflammatory treatment, such as TNF inhibitors, is supported by the observed up-regulation of CD28 expression on T-cells in patients with RA treated with the monoclonal anti-TNF antibody infliximab by Bryl and colleagues (2005).
Regulation (regulation) of Gene_expression (expression) of CD28 in T-cells associated with infliximab, inflammation and rheumatoid arthritis
1) Confidence 0.42 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.30 Pain Relevance 0.36
CD28 expression is regulated at the level of a CD28-specific initiator complex that includes the nuclear proteins nucleolin and hnRPD [49,50].
Regulation (regulated) of Gene_expression (expression) of CD28-specific
2) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.61 Pain Relevance 0.07
However, CD28 loss is not the only, and possibly not the most prominent, change in gene expression in senescent T cells.
Neg (not) Spec (possibly) Regulation (change) of Gene_expression (loss) of CD28 in T cells
3) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.40 Pain Relevance 0.06
CD28 expression is regulated at the level of a CD28-specific initiator complex that includes the nuclear proteins nucleolin and hnRPD [49,50].
Regulation (regulated) of Gene_expression (expression) of CD28
4) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.60 Pain Relevance 0.07

General Comments

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