INT17456

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Context Info
Confidence 0.32
First Reported 1991
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 4.06
Pain Relevance 3.15

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extracellular space (CSF2, POMC) extracellular region (CSF2, POMC) small molecule metabolic process (POMC)
cell-cell signaling (POMC) cytoplasm (POMC) generation of precursor metabolites and energy (POMC)
Anatomy Link Frequency
CSF 3
CSF2 (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Central nervous system 18 92.64 High High
Opioid 20 92.32 High High
antiepileptic Drug 2 82.32 Quite High
Endogenous opioid 2 75.44 Quite High
analgesia 6 53.68 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 10 97.84 Very High Very High Very High
Post-traumatic Stress Disorder 27 92.40 High High
Stress 6 89.12 High High
Convulsion 4 88.08 High High
Injury 3 80.96 Quite High
Traumatic Stress Disorders 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that the mean Leu-enkephalin content in CSF of the epileptic patient group was significantly higher than that of the control group (P less than 0.01), whereas the mean contents of Met-enkephalin and Beta-endorphin in CSF showed no significant change as compared with those of the control group.
CSF Binding (contents) of Beta-endorphin associated with epilepsy and enkephalin
1) Confidence 0.32 Published 1991 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Abstract Doc Link 1907903 Disease Relevance 0.50 Pain Relevance 0.73
It was found that the mean Leu-enkephalin content in CSF of the epileptic patient group was significantly higher than that of the control group (P less than 0.01), whereas the mean contents of Met-enkephalin and Beta-endorphin in CSF showed no significant change as compared with those of the control group.
CSF Binding (contents) of Met-enkephalin associated with epilepsy and enkephalin
2) Confidence 0.32 Published 1991 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Abstract Doc Link 1907903 Disease Relevance 0.50 Pain Relevance 0.73
Immunoreactive beta-lipotropin (ir beta LPH) and pro-opiomelanocortin (irPOMC), both precursors of beta END, were much more plentiful in human CSF than was beta-endorphin itself, as has been previously reported.
CSF Binding (plentiful) of beta-endorphin in CSF
3) Confidence 0.26 Published 1997 Journal Psychoneuroendocrinology Section Abstract Doc Link 9373885 Disease Relevance 0.97 Pain Relevance 0.53
Immunoreactive beta-lipotropin (ir beta LPH) and pro-opiomelanocortin (irPOMC), both precursors of beta END, were much more plentiful in human CSF than was beta-endorphin itself, as has been previously reported.
CSF Binding (plentiful) of irPOMC in CSF
4) Confidence 0.26 Published 1997 Journal Psychoneuroendocrinology Section Abstract Doc Link 9373885 Disease Relevance 1.04 Pain Relevance 0.58
Immunoreactive beta-lipotropin (ir beta LPH) and pro-opiomelanocortin (irPOMC), both precursors of beta END, were much more plentiful in human CSF than was beta-endorphin itself, as has been previously reported.
CSF Binding (plentiful) of pro-opiomelanocortin in CSF
5) Confidence 0.23 Published 1997 Journal Psychoneuroendocrinology Section Abstract Doc Link 9373885 Disease Relevance 1.04 Pain Relevance 0.59

General Comments

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