INT17458

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Context Info
Confidence 0.57
First Reported 1991
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 98
Total Number 101
Disease Relevance 36.77
Pain Relevance 55.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
spinal 26
spinal cord 24
neurons 22
dorsal horn 16
nucleus 6
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 338 100.00 Very High Very High Very High
Pain 264 100.00 Very High Very High Very High
Spinal cord 196 100.00 Very High Very High Very High
Dorsal horn 127 100.00 Very High Very High Very High
Pain threshold 108 100.00 Very High Very High Very High
withdrawal 63 100.00 Very High Very High Very High
Morphine 63 100.00 Very High Very High Very High
Nerve growth factor 31 100.00 Very High Very High Very High
qutenza 29 100.00 Very High Very High Very High
alcohol 24 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 373 100.00 Very High Very High Very High
Pain 354 100.00 Very High Very High Very High
Lung Cancer 112 100.00 Very High Very High Very High
Hypertension 17 100.00 Very High Very High Very High
Hypersensitivity 8 100.00 Very High Very High Very High
Sarcoma 1 100.00 Very High Very High Very High
Neurogenic Inflammation 5 99.90 Very High Very High Very High
Cancer 118 99.84 Very High Very High Very High
Stress 78 99.68 Very High Very High Very High
Pressure And Volume Under Development 36 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither the anti-edematous effect nor the suppression of Fos expression in the superficial spinal laminae was affected by intraperitoneal injection of the opioid antagonist naloxone.
Negative_regulation (suppression) of Gene_expression (expression) of Fos in spinal associated with antagonist, narcan and opioid
1) Confidence 0.57 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 14709347 Disease Relevance 0.53 Pain Relevance 1.09
Intrathecal pre-administration of fentanyl effectively suppresses formalin evoked c-Fos expression in spinal cord of rat.
Negative_regulation (suppresses) of Gene_expression (expression) of c-Fos in spinal cord associated with spinal cord and intrathecal
2) Confidence 0.57 Published 2001 Journal Can J Anaesth Section Title Doc Link 11698319 Disease Relevance 0 Pain Relevance 0.39
In this study, treatment was started just after inducing inflammation, and only one treatment group could prevent c-Fos expression.
Negative_regulation (prevent) of Gene_expression (expression) of c-Fos associated with inflammation
3) Confidence 0.57 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2276498 Disease Relevance 0.39 Pain Relevance 0.86
They block c-fos expression in the TNC in migraine animal models, following superior sagittal sinus stimulation.
Negative_regulation (block) of Gene_expression (expression) of c-fos in superior sagittal sinus associated with migraine
4) Confidence 0.57 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386351 Disease Relevance 1.21 Pain Relevance 1.61
Experience-dependent IEG reinduction during REM sleep is at variance with studies showing that sleep downregulates the expression of IEGs such as zif-268 and c-fos (Basheer et al., 1997; Cirelli and Tononi, 1998, 2000a; O'Hara et al., 1993; Pompeiano et al., 1992, 1994).
Negative_regulation (downregulates) of Gene_expression (expression) of c-fos
5) Confidence 0.57 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.03
Intrathecal grafting of porcine chromaffin cells reduces formalin-evoked c-Fos expression in the rat spinal cord.
Negative_regulation (reduces) of Gene_expression (expression) of c-Fos in spinal cord associated with spinal cord and intrathecal
6) Confidence 0.57 Published 2005 Journal Cell Transplant Section Title Doc Link 16180654 Disease Relevance 0.07 Pain Relevance 0.90
This indicates that PRV injection into the spinal neuron by itself neither stimulated nor suppressed c-fos expression.


Neg (nor) Negative_regulation (suppressed) of Gene_expression (expression) of c-fos in neuron
7) Confidence 0.57 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615335 Disease Relevance 0.34 Pain Relevance 0.04
The expression of c-Fos induced by potassium chloride was also suppressed by dibucaine, tetracaine (concentrations that inhibited 50% of the activity of positive control [IC50s] were 16.2+/-0.2 and 73.2+/-0.7 microM, respectively), and PD 98059, a mitogen-activated/extracellular receptor-regulated kinase inhibitor.
Negative_regulation (suppressed) of Gene_expression (expression) of c-Fos
8) Confidence 0.57 Published 1999 Journal Anesthesiology Section Body Doc Link 10598624 Disease Relevance 0 Pain Relevance 0
We have demonstrated that pre-administered RB101 (40 mg/kg, i.v.), a mixed inhibitor of enkephalin-catabolizing enzymes, decreased spinal c-Fos expression induced 1 h and 30 min after intraplantar (i.pl.) carrageenin (41% reduction, p<0.01).
Negative_regulation (decreased) of Gene_expression (expression) of c-Fos in spinal associated with enkephalin
9) Confidence 0.57 Published 1999 Journal Brain Res. Section Abstract Doc Link 10407116 Disease Relevance 0 Pain Relevance 0.43
The results showed that intrthecal injection of SST increases pain threshold, prevented pain response and c-fos expression in spinal cord induced by SP.
Negative_regulation (prevented) of Gene_expression (expression) of c-fos in spinal cord associated with pain, pain threshold, somatostatin and spinal cord
10) Confidence 0.57 Published 1997 Journal Sheng Li Xue Bao Section Abstract Doc Link 9812827 Disease Relevance 0.46 Pain Relevance 1.04
Pretreatment with fentanyl showed the most profound suppression of c-Fos expression (P <0.01).
Negative_regulation (suppression) of Gene_expression (expression) of c-Fos
11) Confidence 0.57 Published 2001 Journal Can J Anaesth Section Body Doc Link 11698319 Disease Relevance 0 Pain Relevance 0
Nociception, induced by intraplantar injection of formalin, was mitigated by vinpocetine; increased expression of c-fos in the ipsilateral, segmentally related upper dorsal horn was also prevented.
Negative_regulation (prevented) of Gene_expression (expression) of c-fos in dorsal horn associated with nociception and dorsal horn
12) Confidence 0.57 Published 2008 Journal Ann. Anat. Section Abstract Doc Link 18413267 Disease Relevance 0.77 Pain Relevance 0.50
In addition, 10 mg/kg 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)4,5-dihydro-1H-imidazole (RX 821002), an alpha(2A/D)-adrenoceptor antagonist, and 20 mg/kg haloperidol, a dopamine antagonist, also block alcohol-induced c-Fos expression in Edinger-Westphal neurons.
Negative_regulation (block) of Gene_expression (expression) of c-Fos in neurons associated with dopamine, antagonist and alcohol
13) Confidence 0.57 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0.15 Pain Relevance 0.91
The present study demonstrates that both xenogeneic porcine and bovine chromaffin cells transplanted into the spinal subarachnoid space of the rat can suppress formalin-evoked c-Fos expression equally, in parallel with suppression of nociceptive behaviors in the tonic phase of the test.
Negative_regulation (suppress) of Gene_expression (expression) of c-Fos in spinal associated with nociception
14) Confidence 0.57 Published 2005 Journal Cell Transplant Section Abstract Doc Link 16180654 Disease Relevance 0.24 Pain Relevance 0.60
But significant reduction of c-Fos expression by CNQX was seen in deeper laminae (laminae III-X).
Negative_regulation (reduction) of Gene_expression (expression) of c-Fos
15) Confidence 0.57 Published 2004 Journal J. Chem. Neuroanat. Section Abstract Doc Link 15482902 Disease Relevance 0 Pain Relevance 0.36
Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats.
Negative_regulation (decrease) of Gene_expression (expression) of c-fos in spinal associated with pain, ketamine and arthritis
16) Confidence 0.57 Published 2004 Journal Anesth. Analg. Section Title Doc Link 15281522 Disease Relevance 0.78 Pain Relevance 1.11
Intra-RVLM rilmenidine decreased c-Fos expression, and these responses were abolished by efaroxan but not by SK&F 86466.
Negative_regulation (decreased) of Gene_expression (expression) of c-Fos in RVLM associated with rostral ventrolateral medulla
17) Confidence 0.57 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15965355 Disease Relevance 0.13 Pain Relevance 0.79
In the NTS and RVLM, a trend of decrease of c-fos expression was also observed after systemic neonatal capsaicin treatment.
Negative_regulation (decrease) of Gene_expression (expression) of c-fos in RVLM associated with rostral ventrolateral medulla and qutenza
18) Confidence 0.57 Published 2003 Journal Brain Res. Section Abstract Doc Link 12618348 Disease Relevance 0.27 Pain Relevance 0.80
A decrease of the CD-induced c-fos expression after sensory vagal denervation by perivagal capsaicin treatment was only observed in brainstem nuclei (NTS and RVLM).
Negative_regulation (decrease) of Gene_expression (expression) of c-fos in brainstem associated with medulla, rostral ventrolateral medulla and qutenza
19) Confidence 0.57 Published 2003 Journal Brain Res. Section Abstract Doc Link 12618348 Disease Relevance 0.37 Pain Relevance 0.90
Nociception, induced by intraplantar injection of formalin, was mitigated by perineural application of vinpocetine; also formalin-induced expression of c-fos in the ipsilateral, segmentally related superficial dorsal horn, was prevented by this treatment.
Negative_regulation (prevented) of Gene_expression (expression) of c-fos in dorsal horn associated with nociception and dorsal horn
20) Confidence 0.57 Published 2010 Journal Ideggyogy Sz Section Abstract Doc Link 20648783 Disease Relevance 0.54 Pain Relevance 0.58

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