INT174588

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 11.45
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GLG1)
Anatomy Link Frequency
blood 3
endothelium 1
heart 1
GLG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 154 99.62 Very High Very High Very High
cva 106 99.36 Very High Very High Very High
Angina 54 97.84 Very High Very High Very High
depression 6 86.00 High High
imagery 28 73.76 Quite High
ischemia 74 62.16 Quite High
positron emission tomography 30 54.20 Quite High
alcohol 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
beta blocker 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 130 99.36 Very High Very High Very High
Diabetes Mellitus 150 99.18 Very High Very High Very High
Hypertrophy 12 99.18 Very High Very High Very High
Cardiomyopathy 118 99.00 Very High Very High Very High
Dilated Cardiomyopathy 84 98.20 Very High Very High Very High
Angina 30 97.84 Very High Very High Very High
Disease 84 95.12 Very High Very High Very High
Hyperhomocysteinemia 12 94.44 High High
Hyperlipidemia 36 93.36 High High
Coronary Vasospasm 6 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LV hypertrophy, excessive intramyocardial pressure) of CFR reduction.
Gene_expression (reduction) of CFR associated with hypertrophy
1) Confidence 0.67 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.95 Pain Relevance 0.18
In conclusion, CFR is preserved at room temperature in vasospastic angina, but, compared to controls, increases in coronary blood flow in response to cold stimulation are blunted and CFR is decreased.
Gene_expression (preserved) of CFR in blood associated with cva
2) Confidence 0.65 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808592 Disease Relevance 0.87 Pain Relevance 0.41
In contrast we found a modest reduction of the CFR due to sildenafil in half of the diabetic study patients, but in none of them did CFR decrease below 200 %, which is known to represent a cut-off value to indicate clinically relevant myocardial minor perfusion during exercising [8].
Neg (none) Gene_expression (decrease) of CFR associated with diabetes mellitus
3) Confidence 0.64 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 0.76 Pain Relevance 0.12
In contrast we found a modest reduction of the CFR due to sildenafil in half of the diabetic study patients, but in none of them did CFR decrease below 200 %, which is known to represent a cut-off value to indicate clinically relevant myocardial minor perfusion during exercising [8].
Gene_expression (reduction) of CFR associated with diabetes mellitus
4) Confidence 0.64 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 0.71 Pain Relevance 0.09
Thus, we can not be certain that normal CFR starts from 3.0 because CFR values higher than 5.0 were recorded in humans.
Gene_expression (values) of CFR
5) Confidence 0.58 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.95 Pain Relevance 0.03
Structural changes (remodelling) in coronary microcirculation can themselves be responsible of CFR reduction.
Gene_expression (reduction) of CFR
6) Confidence 0.58 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.60 Pain Relevance 0.12
Thus, we can not be certain that normal CFR starts from 3.0 because CFR values higher than 5.0 were recorded in humans.
Gene_expression (values) of CFR
7) Confidence 0.58 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.84 Pain Relevance 0.03
The relationship between unfavourable prognosis and reduced CFR in patients with hypertrophic or idiopathic dilated cardiomyopathies was recently reported [46,47].
Gene_expression (prognosis) of CFR associated with dilated cardiomyopathy
8) Confidence 0.58 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.53 Pain Relevance 0.11
These highly selecting criteria probably was not fulfilled in previous studies, in particular the oldest, where the newest recognized factors limiting CFR were not yet known.
Gene_expression (limiting) of CFR
9) Confidence 0.58 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 1.26 Pain Relevance 0.04
In this study, coronary blood flow incrementation by cold stimulation was lower in VA patients than in controls, and CFR decreased and CVRI increased in VA under cold stimulation.
Gene_expression (decreased) of CFR in blood associated with cva
10) Confidence 0.57 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808592 Disease Relevance 1.07 Pain Relevance 0.42
Repeat measurements of blood pressure and CFR were performed thereafter.


Gene_expression (pressure) of CFR in blood
11) Confidence 0.56 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 0.41 Pain Relevance 0.08
CFR values were expressed in percent after multiplication with 100 (Figure 1).
Gene_expression (expressed) of CFR
12) Confidence 0.50 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 0.20 Pain Relevance 0.14
Secondly, we saw marked variation in CFR (range 2.3 – 7.8) and moderate variability in totally reproduced CFR studies (CV 11.5 ± 8.7%), but intra-observer variability was low (2.6 ± 4.0%) indicating a small methodological error and greater physiological variation.
Gene_expression (reproduced) of CFR
13) Confidence 0.30 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2427009 Disease Relevance 0.35 Pain Relevance 0
Therefore, aside from the different mechanisms in preserving CFR, it is reasonable to accept the weak relationship found in this study enrolling RV dysfunction over RCA versus LAD CFR, in conditions of advanced chronic non-ischemic heart failure syndrome.
Gene_expression (preserving) of CFR in heart associated with syndrome and myocardial infarction
14) Confidence 0.21 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2137923 Disease Relevance 0.58 Pain Relevance 0
Generally it is easier to explore the CFR in left coronary circulation (LAD) due to its topography [16-19], even non-invasively [48,53,54], avoiding time-consuming and the technical limitations concerning RCA circulation assessment.
Gene_expression (explore) of CFR
15) Confidence 0.18 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2137923 Disease Relevance 0.20 Pain Relevance 0
Nevertheless, most of recent studies accords with the non endothelium-dependent (i.e., adenosine and dipyridamole) CFR reduction in dilated non-ischemic cardiomyopathy setting, principally studying LAD territory – justified mainly due LV structural and mechanics deterioration aside the microvascular disarrangements, as described by Rigo et al. and others [16,19,47,48].
Gene_expression (reduction) of CFR in endothelium associated with cardiomyopathy and adenocard
16) Confidence 0.18 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2137923 Disease Relevance 0.80 Pain Relevance 0.23
The several vascular intrinsic and extrinsic mechanisms enrolled in preserving the CFR (19) possibly were in account to promote our findings.
Gene_expression (preserving) of CFR
17) Confidence 0.18 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2137923 Disease Relevance 0.37 Pain Relevance 0.04

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