INT174589

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 37
Total Number 40
Disease Relevance 32.41
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GLG1)
Anatomy Link Frequency
blood 4
coronary artery 3
lumen 2
endothelium 2
aortic valve 2
GLG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 156 99.78 Very High Very High Very High
adenocard 271 99.62 Very High Very High Very High
ischemia 160 98.76 Very High Very High Very High
Angina 149 94.20 High High
positron emission tomography 120 94.20 High High
depression 24 92.52 High High
imagery 99 91.72 High High
Bioavailability 6 88.36 High High
headache 8 60.72 Quite High
medulla 2 51.04 Quite High
Disease Link Frequency Relevance Heat
Dilated Cardiomyopathy 219 99.92 Very High Very High Very High
Disease 273 99.90 Very High Very High Very High
Aging 24 99.82 Very High Very High Very High
Cv General 3 Under Development 228 99.78 Very High Very High Very High
Increased Venous Pressure Under Development 177 99.76 Very High Very High Very High
Hypertension 171 99.70 Very High Very High Very High
Congenital Anomalies 198 99.32 Very High Very High Very High
Cardiovascular Disease 102 99.24 Very High Very High Very High
Diabetes Mellitus 346 99.18 Very High Very High Very High
Hypertrophy 48 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, the reduction of CFR may be associated with three main kinds of abnormalities [2,3,22,23] (Table 3, Figure 3) and it is even possible for two factors to co-operate simultaneously.
Negative_regulation (reduction) of CFR associated with congenital anomalies
1) Confidence 0.58 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.34 Pain Relevance 0.12
A gradual decrease of CFR, parallel to more advanced stages of microvascular disease, was observed in diabetic patients, patients with syndrome X and also hypertensive patients without overt coronary artery stenosis (Table 4).
Negative_regulation (decrease) of CFR in coronary artery associated with coronary stenosis, syndrome, diabetes mellitus, hypertension and disease
2) Confidence 0.58 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 1.45 Pain Relevance 0.09
It is also of interest that the reduction of CFR is reversible in some cases, for instance after regression of LV hypertrophy subsequent to aortic valve replacement in patients with aortic valve stenosis, after anti-hypertensive treatment or even after cholesterol treatment [37-42].
Negative_regulation (reduction) of CFR in aortic valve associated with hypertrophy, hypertension and cardiac stenosis
3) Confidence 0.58 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 1.21 Pain Relevance 0
Thus, sildenafil is unlikely to enhance myocardial ischemia during physical exercise in men with metabolically, severely reduced CFR.
Negative_regulation (reduced) of CFR associated with coronary artery disease and ischemia
4) Confidence 0.56 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 1.23 Pain Relevance 0.29
According to Hoffman [2] the reduction of global CFR from 4.0 to 2.0 could be associated with the loss of flow reserve in a part or all of the subendocardial layer of the myocardium.
Negative_regulation (reduction) of CFR in myocardium
5) Confidence 0.51 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.18 Pain Relevance 0.08
In patients with hypertrophic cardiomyopathy, a reduced arteriolar lumen was associated to a reduced CFR [24,25].
Negative_regulation (reduced) of CFR in lumen associated with hypertrophic cardiomyopathy
6) Confidence 0.51 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.70 Pain Relevance 0.07
A decreased arteriolar wall/lumen ratio correlates with reduction of CFR as well as with abnormalities of derived parameters as coronary resistance reserve.
Negative_regulation (reduction) of CFR in lumen associated with congenital anomalies
7) Confidence 0.51 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.89 Pain Relevance 0.16
The concept of coronary flow reserve (CFR) and transmural reduction of CFR
Negative_regulation (reduction) of CFR
8) Confidence 0.51 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0 Pain Relevance 0
How much coronary microvascular disease may reduce CFR?
Spec (may) Negative_regulation (reduce) of CFR associated with disease
9) Confidence 0.51 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 1.15 Pain Relevance 0.14
In VA patients, CFR was preserved at baseline, but coronary blood flow increase in response to cold stimulation was blunted and CFR was decreased.
Negative_regulation (decreased) of CFR in blood associated with cva
10) Confidence 0.49 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2808592 Disease Relevance 0.76 Pain Relevance 0.47
LV hypertrophy, excessive intramyocardial pressure) of CFR reduction.
Negative_regulation (reduction) of CFR associated with hypertrophy
11) Confidence 0.43 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.95 Pain Relevance 0.18
In the subgroup of severe aortic stenosis (aortic valve area <0.8 cm2) CFR was <2.0 both at subendocardial and subepicardial levels and in two of these patients subendocardial CFR was <1.0 (lack of CFR).
Negative_regulation (lack) of CFR in aortic valve associated with cardiac stenosis
12) Confidence 0.43 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.32 Pain Relevance 0.14
In a study by Marks at al. [45], reduced CFR due to unspecified microvascular disease predicted increased mortality – 20% vs. 7% in a group with normal CFR (p < 0.016).
Negative_regulation (reduced) of CFR in unspecified associated with disease
13) Confidence 0.43 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.50 Pain Relevance 0.12
Other investigators [13] demonstrated that aging-induced reduction of CFR is a result of increased coronary blood flow at rest, whereas maximal blood flow remained relatively unchanged during the years.
Negative_regulation (reduction) of CFR in blood associated with aging
14) Confidence 0.43 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.22 Pain Relevance 0.05
The decrease of CFR was mainly seen in the presence of left ventricular hypertrophy, obesity and an inadequately adjusted diabetes, a constellation that is paralleled by severe disturbance of endothelial function.
Negative_regulation (decrease) of CFR associated with left ventricular hypertrophy, diabetes mellitus and obesity
15) Confidence 0.41 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 1.01 Pain Relevance 0.03
In contrast we found a modest reduction of the CFR due to sildenafil in half of the diabetic study patients, but in none of them did CFR decrease below 200 %, which is known to represent a cut-off value to indicate clinically relevant myocardial minor perfusion during exercising [8].
Negative_regulation (reduction) of CFR associated with diabetes mellitus
16) Confidence 0.41 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 0.71 Pain Relevance 0.09
In contrast we found a modest reduction of the CFR due to sildenafil in half of the diabetic study patients, but in none of them did CFR decrease below 200 %, which is known to represent a cut-off value to indicate clinically relevant myocardial minor perfusion during exercising [8].
Negative_regulation (decrease) of CFR associated with diabetes mellitus
17) Confidence 0.41 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 0.76 Pain Relevance 0.12
The decrease of CFR was more pronounced in obese diabetics (BMI > 25 kg/m2) who had a HbA1c > 7.0 % and left ventricular hypertrophy, while for the other patients CFR tended to increase after sildenafil (?
Negative_regulation (decrease) of CFR associated with left ventricular hypertrophy, diabetes mellitus and obesity
18) Confidence 0.41 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 0.90 Pain Relevance 0.13
CFR reduction may be reversible, for instance after regression of left ventricular hypertrophy subsequent to valve replacement in patients with aortic stenosis, after anti-hypertensive treatment or using cholesterol lowering drugs.
Negative_regulation (reduction) of CFR associated with left ventricular hypertrophy, hypertension and cardiac stenosis
19) Confidence 0.37 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 1.27 Pain Relevance 0.04
Also in hypertensive patients [26] reduced CFR correlated with increased coronary arteriolar wall thickness, i.e, arteriolar remodelling.
Negative_regulation (reduced) of CFR associated with hypertension
20) Confidence 0.37 Published 2005 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1201155 Disease Relevance 0.75 Pain Relevance 0.07

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