INT17459

Context Info Confidence 0.67 First Reported 1991 Last Reported 2010 Negated 10 Speculated 7 Reported most in Abstract Documents 182 Total Number 189 Disease Relevance 53.45 Pain Relevance 96.38

nucleoplasm (FOS) aging (FOS) nucleolus (FOS) nucleus (FOS)

Anatomy Link Frequency neurons 51 spinal 22 striatum 20 spinal cord 17 nucleus 13 FOS (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 425 100.00 Morphine 176 100.00 Dopamine 131 100.00 alcohol 128 100.00 Spinal cord 113 100.00 qutenza 77 100.00 Nerve growth factor 22 100.00 Neuronal nitric oxide synthase 17 100.00 withdrawal 184 99.98 cocaine 153 99.98

Disease Link Frequency Relevance Heat Pain 369 100.00 Hypoxia 126 100.00 Shock 18 100.00 INFLAMMATION 131 99.98 Hypotension 3 99.98 Thyroid Neoplasm 169 99.88 Hypersensitivity 29 99.88 Rheumatoid Arthritis 239 99.84 Disease 127 99.76 Cancer 179 99.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[Effect of morphine on pain threshold and C-fos expression induced by substance P].

Positive_regulation (induced) of Gene_expression (expression) of C-fos associated with pain threshold, substance p and morphine

1) Confidence 0.67 Published 1996 Journal Zhen Ci Yan Jiu Section Title Doc Link 9387360 Disease Relevance 0.55 Pain Relevance 0.91

Also using immunohistochemistry to identify potential intracellular mechanisms associated with alcohol-induced c-Fos expression in Edinger-Westphal, we show time-dependent increases in serine 727 phospho-signal transducer and activator of transcription 3 (Stat3) but no changes in phospho-cAMP response element-binding protein and phospho-Elk1.

Positive_regulation (induced) of Gene_expression (expression) of c-Fos associated with alcohol

2) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0.07 Pain Relevance 0.93

Herein, we characterize the pharmacological and signal transduction mechanisms related to alcohol-induced c-Fos expression in Edinger-Westphal neurons.

Positive_regulation (-) of Gene_expression (expression) of c-Fos in neurons associated with alcohol

3) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0.10 Pain Relevance 0.42

Using immunohistochemistry, we show that pretreatment with gamma-aminobutyric acid (GABA)-ergic antagonists (4 mg/kg bicuculline and 45 mg/kg pentylenetetrazole) attenuates induction of c-Fos expression by alcohol (2.4 g/kg, intraperitoneal).

Positive_regulation (induction) of Gene_expression (expression) of c-Fos associated with gaba, antagonist and alcohol

4) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0.14 Pain Relevance 0.59

These findings suggest that alcohol-induced c-Fos expression in Edinger-Westphal results from direct interactions with GABA(A) receptors, which are modified by alpha(2A/D)-adrenoceptors and dopamine receptors.

Positive_regulation (-) of Gene_expression (expression) of c-Fos associated with gaba, dopamine receptor and alcohol

5) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0.08 Pain Relevance 1.06

The modulation of CD-induced c-fos expression exclusively in the NTS by granisetron points to a role of 5-HT(3) receptor antagonists in the modulation of vago-vagal sensomotoric reflexes rather than an influence on forebrain nuclei involved in nociception.

Positive_regulation (induced) of Gene_expression (expression) of c-fos in forebrain associated with nociception and antagonist

6) Confidence 0.67 Published 2003 Journal Brain Res. Section Abstract Doc Link 12618348 Disease Relevance 0.26 Pain Relevance 0.47

Pretreatment with granisetron significantly reduced the number of c-FLI-positive cells/section in the NTS by 40%, but had no significant effect on the CD-induced c-fos expression in other brain areas.

Positive_regulation (induced) of Gene_expression (expression) of c-fos in brain

7) Confidence 0.67 Published 2003 Journal Brain Res. Section Abstract Doc Link 12618348 Disease Relevance 0.27 Pain Relevance 0.75

A decrease of the CD-induced c-fos expression after sensory vagal denervation by perivagal capsaicin treatment was only observed in brainstem nuclei (NTS and RVLM).

Positive_regulation (induced) of Gene_expression (expression) of c-fos in brainstem associated with medulla, rostral ventrolateral medulla and qutenza

8) Confidence 0.67 Published 2003 Journal Brain Res. Section Abstract Doc Link 12618348 Disease Relevance 0.36 Pain Relevance 0.89

In all other activated brain nuclei examined, the CD-related induction of c-fos expression was diminished only after systemic neonatal capsaicin treatment.

Positive_regulation (induction) of Gene_expression (expression) of c-fos in brain associated with qutenza

9) Confidence 0.67 Published 2003 Journal Brain Res. Section Abstract Doc Link 12618348 Disease Relevance 0.23 Pain Relevance 0.81

Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptors.

Positive_regulation (induction) of Gene_expression (expression) of c-fos in brain associated with c fibre and qutenza

10) Confidence 0.67 Published 2003 Journal Brain Res. Section Title Doc Link 12618348 Disease Relevance 0.35 Pain Relevance 0.55

Epibatidine produced a robust (2-5-fold) increase in c-Fos expression, which was not dose dependent, in all of these areas examined except the nucleus raphe magnus.

Spec (examined) Positive_regulation (increase) of Gene_expression (expression) of c-Fos in nucleus associated with raphe magnus

11) Confidence 0.67 Published 2003 Journal Synapse Section Abstract Doc Link 12774304 Disease Relevance 0 Pain Relevance 1.04

Vector-mediated GDNF expression blocked the nonnoxious touch-induced increase in c-fos expression in dorsal horn characteristic of the painful state.

Positive_regulation (increase) of Gene_expression (expression) of c-fos in dorsal horn associated with pain and dorsal horn

12) Confidence 0.67 Published 2003 Journal Mol. Ther. Section Abstract Doc Link 12946309 Disease Relevance 0.89 Pain Relevance 0.92

Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms.

Positive_regulation (-) of Gene_expression (expression) of c-Fos in Edinger-Westphal nucleus associated with alcohol

13) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12130710 Disease Relevance 0.15 Pain Relevance 0.56

In addition, 10 mg/kg 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)4,5-dihydro-1H-imidazole (RX 821002), an alpha(2A/D)-adrenoceptor antagonist, and 20 mg/kg haloperidol, a dopamine antagonist, also block alcohol-induced c-Fos expression in Edinger-Westphal neurons.

Positive_regulation (-) of Gene_expression (expression) of c-Fos in neurons associated with dopamine, antagonist and alcohol

14) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0.15 Pain Relevance 0.91

Studies with oligonucleotide probes for enkephalin (ENK) and dynorphin (DYN) indicated that clozapine increases c-fos expression in both ENK and DYN containing neurons in the NAc (ENK 40%, DYN 53%) and LSN (ENK 32%, DYN 59%).

Positive_regulation (increases) of Gene_expression (expression) of c-fos in LSN associated with nucleus accumbens, dynorphin and enkephalin

15) Confidence 0.67 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9629567 Disease Relevance 0 Pain Relevance 1.57

The present results demonstrate that haloperidol and clozapine target different populations of neurons even in regions such as the NAc and LSN, where they both increase c-fos expression.

Positive_regulation (increase) of Gene_expression (expression) of c-fos in neurons associated with nucleus accumbens

16) Confidence 0.67 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9629567 Disease Relevance 0 Pain Relevance 1.44

Haloperidol also increases c-fos expression in ENK and DYN containing neurons, albeit in a different pattern (striatum: ENK 93%, DYN 20%; nucleus accumbens: ENK 46%, DYN 36%; lateral septum: ENK 29%, DYN 18%).

Positive_regulation (increases) of Gene_expression (expression) of c-fos in neurons associated with nucleus accumbens, dynorphin and enkephalin

17) Confidence 0.67 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9629567 Disease Relevance 0 Pain Relevance 1.64

Therefore, the sensitization of morphine-induced c-fos expression in parts of the striatum seems to correlate with the locomotor effects of repeated morphine application, whereas the observed sensitization in several limbic brain areas might reflect emotional phenomena like increased self-administration in rats or drug craving in humans.

Positive_regulation (induced) of Gene_expression (expression) of c-fos in striatum associated with morphine

18) Confidence 0.67 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10521594 Disease Relevance 0.08 Pain Relevance 0.74

In contrast, repeated dosage twice daily for 10 days and ascending from 10 to 50 mg/kg resulted in a sharply delineated morphine-induced c-fos synthesis in the dorsomedial and lateral striatum, lateral septum, medial mammillary nuclei, anterior thalamus and, in part masked by a high background due to injection stress, in the cingulate cortex.

Positive_regulation (induced) of Gene_expression (synthesis) of c-fos in thalamus associated with stress, thalamus and morphine

19) Confidence 0.67 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10521594 Disease Relevance 0.16 Pain Relevance 0.82

CONCLUSIONS: Dibucaine and tetracaine at clinical concentrations were found to inhibit the activation of MAP kinase and the expression of c-Fos mediated by L-type Ca2+ channels in PC12 cells.

Positive_regulation (mediated) of Gene_expression (expression) of c-Fos

20) Confidence 0.67 Published 1999 Journal Anesthesiology Section Body Doc Link 10598624 Disease Relevance 0 Pain Relevance 0

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