INT174600

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.76
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epithelial cells 2
olfactory system 1
lung 1
nervous system 1
eggs 1
Ducm1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 140 99.98 Very High Very High Very High
Inflammation 115 99.44 Very High Very High Very High
tolerance 12 98.44 Very High Very High Very High
imagery 16 94.64 High High
fibrosis 40 86.48 High High
cytokine 38 83.44 Quite High
Inflammatory response 5 70.16 Quite High
adenocard 1 21.84 Low Low
Neuropeptide 75 20.24 Low Low
Rsd 6 19.24 Low Low
Disease Link Frequency Relevance Heat
Pneumonia 55 99.64 Very High Very High Very High
Targeted Disruption 163 98.40 Very High Very High Very High
Fasciculation 7 97.68 Very High Very High Very High
Lung Injury 195 95.16 Very High Very High Very High
Viral Infection 76 94.56 High High
Shock 22 93.12 High High
Stress 39 90.08 High High
Respiratory Syncytial Virus 10 89.84 High High
Non-small-cell Lung Cancer 33 86.84 High High
Fibrosis 5 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The above results suggested that the hsp70 inducible system may be useful for a transgenic RNAi approach and encouraged us to design a piggyBac vector for heat-inducible expression of the ftz-f1 dsRNA.
Gene_expression (expression) of dsRNA associated with targeted disruption
1) Confidence 0.75 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0.41 Pain Relevance 0
Table 2 shows that the injection of control dsRNA into adult females did not alter oviposition, whereas injection of blt dsRNA, which altered ovarian morphology (Fig. 5), significantly reduced the number of eggs laid.


Gene_expression (injection) of dsRNA in eggs
2) Confidence 0.65 Published 2003 Journal BMC Genomics Section Body Doc Link PMC194572 Disease Relevance 0 Pain Relevance 0
GFP dsRNA served effectively as a negative control, since GFP dsRNA wells were phenotypically indistinguishable from other negative controls such as lacZ dsRNA or water.
Gene_expression (wells) of dsRNA
3) Confidence 0.65 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2435276 Disease Relevance 0.09 Pain Relevance 0.05
GFP dsRNA served effectively as a negative control, since GFP dsRNA wells were phenotypically indistinguishable from other negative controls such as lacZ dsRNA or water.
Neg (negative) Gene_expression (served) of dsRNA
4) Confidence 0.65 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2435276 Disease Relevance 0.08 Pain Relevance 0.05
dsRNA preparation
Gene_expression (preparation) of dsRNA
5) Confidence 0.65 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.43 Pain Relevance 0
Inhibiting RNAi by removing rde-1 or rde-4 alleviates this defect, suggesting that ADARs could play a special role in the nervous system by preventing endogenously expressed dsRNAs from activating RNAi (Tonkin and Bass, 2003).
Gene_expression (expressed) of dsRNA in nervous system
6) Confidence 0.65 Published 2006 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737212 Disease Relevance 0.06 Pain Relevance 0
When injected with hsp70 dsRNA prior to entering diapause, neither the incidence nor length of diapause appear to be affected, but injection of hsp70 dsRNA leads to a dramatic reduction in cold tolerance, a key component of the diapause state.
Gene_expression (injection) of dsRNA associated with tolerance
7) Confidence 0.65 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0.39 Pain Relevance 0.13
To this end we are synthesizing fasciclin 11 dsRNA fragments in order to perform RNA interference (RNAi) and thus knock out fasciclin 11 in the developing olfactory system.


Gene_expression (synthesizing) of dsRNA in olfactory system associated with targeted disruption
8) Confidence 0.58 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0.28 Pain Relevance 0
CT (CXCR2 expression from dsRNA-treated animals normalized to endogenous 18S)-?
Gene_expression (expression) of dsRNA
9) Confidence 0.05 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.13 Pain Relevance 0
The following is an example for comparing CXCR2 expression from dsRNA-treated animals and ssRNA-treated controls.
Gene_expression (expression) of dsRNA
10) Confidence 0.05 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.05 Pain Relevance 0
In this study, we hypothesized that the interaction between CXCR2 and ELR-positive CXC chemokines expressed during dsRNA-induced lung inflammation is critical in mediating neutrophil recruitment, a pivotal process required for dsRNA induced lung injury in viral infections.
Gene_expression (expressed) of dsRNA in lung associated with lung injury, chemokine, inflammation, viral infection and pneumonia
11) Confidence 0.05 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.67 Pain Relevance 0.42
Elegant in vitro studies have demonstrated that dsRNA can induce IL-8 expression from human bronchial epithelial cells [16].
Gene_expression (expression) of dsRNA in epithelial cells
12) Confidence 0.04 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.62 Pain Relevance 0.15
The upregulation of TLR3 in dsRNA-exposed mouse airways suggests a positive feedback system in which epithelial cells exposed to dsRNA increase TLR3 expression on their cell surface.
Gene_expression (expression) of dsRNA in epithelial cells
13) Confidence 0.04 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.54 Pain Relevance 0.10

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