INT174653
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Unsurprisingly, pyrin is found in large quantities in neutrophils and released in response to inflammatory stimuli. | |||||||||||||||
| |||||||||||||||
|
This region might also be a PEST phosphatase interaction surface, since pyrin and PEST phosphatase are thought to bind to the same region of PSTPIP1 and the PAPA mutations increase affinity for pyrin while decreasing affinity for PEST phophatases [5]. | |||||||||||||||
| |||||||||||||||
|
Finally, we demonstrate that pyrin can recruit PSTPIP1 into aggregations (specks) of ASC, another pyrin binding protein. | |||||||||||||||
| |||||||||||||||
|
It was not possible to simultaneously image both pyrin and PSTPIP1 in human cells since both primary antibodies were generated in rabbits.
| |||||||||||||||
| |||||||||||||||
|
The gene locus responsible for FMF was identified in 1992 and localized to the short arm of chromosome 16. | |||||||||||||||
| |||||||||||||||
|
In this case, pyrin is localized in 100% of specks, but PSTPIP1 is never localized in specks (Figure 9QS). | |||||||||||||||
| |||||||||||||||
|
This is totally the reverse in other cases, as Southeastern Turkey, where the presence of a MEFV mutation is obligatory to diagnose FMF. | |||||||||||||||
| |||||||||||||||
|
415 of 1100 patients suspected as FMF were diagnosed as having FMF according to Yalc? | |||||||||||||||
| |||||||||||||||
|
We found that the PAPA-causing mutations, A230T and E250Q (Figure 6SX), were reticularized by pyrin in a manner similar to that seen with wildtype PSTPIP1. | |||||||||||||||
| |||||||||||||||
|
Figure 4FH shows that the filaments formed by PSTPIP1(-SH3) effectively recruited full length pyrin. | |||||||||||||||
| |||||||||||||||
|
If this is the case, then pyrin and ASC should only co-localize in the presence of PSTPIP1. | |||||||||||||||
| |||||||||||||||
|
In this case, pyrin is localized in 100% of specks, but PSTPIP1 is never localized in specks (Figure 9QS). | |||||||||||||||
| |||||||||||||||
|
He now argued that puerperal fever could take any one of a number of different forms, which he organized into a complex classification, and that some of these were caused by inflammationusually brought on by a plethora.83 | |||||||||||||||
| |||||||||||||||
|
In his Essays on the puerperal fever and on puerperal convulsions of 1768, he argued that puerperal fever began as an inflammatory condition, but progressed to a putrid disease after some days. | |||||||||||||||
| |||||||||||||||
|
Butter saw all fevers as disorders of the first passages (that is, the alimentary canal)102 whilst Walsh argued that puerperal fever was essentially a synochusa disease of debility rather than excitability or inflammation.103 | |||||||||||||||
| |||||||||||||||
|
As pressure was released from the aorta, the main arteries and the small abdominal vessels, blood would rush into those vessels with a force superior to their resistance, and by putting them violently on the stretch, may occasion pain, inflammation and fever.56 This occurred most readily in the omentum and intestines where the blood vessels were numerous and most yielding.57 Along with the local inflammation of the abdominal viscera, the diversion of a large volume of blood into the lower abdomen caused deficiency elsewhere, particularly in the heart and brain, which was rapidly followed by an over-compensation and the pooling of blood in these organs once more, accompanied by anxiety and oppression at the breast and praecordia.58 The cold fit which followed was caused by a draining of blood from the extremities, and the vomiting and diarrhoea which may accompany this were the result of a pooling of blood in the vena portae ventralis, leading to the excessive secretion of bile.59 Leake's description of the effects of puerperal fever offers a vivid account of mechanistic and hydraulic movements of blood within the circulatory system, redolent of an almost tidal sense of blood washing rapidly into and out of the small vessels, creating alternately heat and cold, pain and relaxation. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.