INT174657

Context Info Confidence 0.01 First Reported 2003 Last Reported 2003 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.53 Pain Relevance 0.30

signal transduction (IL8, LTBR) extracellular space (IL8) extracellular region (IL8) intracellular (IL8)

Anatomy Link Frequency polymorphonuclear neutrophils 2 IL8 (Homo sapiens) LTBR (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 85.60 Crohn's disease 1 80.56 cytokine 1 79.44 rheumatoid arthritis 1 78.96 Infliximab 17 57.44 Arthritis 4 9.12 Central nervous system 1 5.00 Pain 1 5.00 Etanercept 1 5.00

Disease Link Frequency Relevance Heat Disease 30 94.52 INFLAMMATION 6 85.60 Necrosis 4 82.12 Cancer 4 81.76 Rheumatoid Arthritis 1 78.96 Neurologic Manifestations 1 76.08 Arthritis 7 73.76 Retinal Vasculitis 1 72.60 Uveitis 1 71.68 Recurrence 3 49.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TNF-alpha and interleukin-8 might increase the expression of the CD11b-CD18 constitutively present on the polymorphonuclear neutrophils membrane and facilitate their rolling and diapedesis through the vascular endothelial wall [2,6].

interleukin-8 Spec (might) Positive_regulation (increase) of Gene_expression (expression) of CD18 in polymorphonuclear neutrophils

1) Confidence 0.01 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC194711 Disease Relevance 1.53 Pain Relevance 0.30

General Comments

This test has worked.