INT174672

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Context Info
Confidence 0.26
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 4.82
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Luc7l3) mRNA processing (Luc7l3) plasma membrane (Luc7l3)
nucleus (Luc7l3) DNA binding (Luc7l3) response to stress (Luc7l3)
Anatomy Link Frequency
photoreceptors 1
neural 1
Luc7l3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 450 99.92 Very High Very High Very High
Action potential 92 99.82 Very High Very High Very High
GABA receptor 54 99.56 Very High Very High Very High
gABA 774 98.20 Very High Very High Very High
tetrodotoxin 83 97.82 Very High Very High Very High
GABAergic 79 97.58 Very High Very High Very High
Neurotransmitter 138 96.32 Very High Very High Very High
antagonist 173 89.80 High High
mu opioid receptor 420 89.76 High High
agonist 173 89.16 High High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 176 99.96 Very High Very High Very High
Ganglion Cysts 157 98.32 Very High Very High Very High
Aids-related Complex 160 97.28 Very High Very High Very High
Viral Infection 4 96.88 Very High Very High Very High
Repression 40 92.08 High High
Contagious Ecthyma 70 90.68 High High
Stress 10 70.56 Quite High
Targeted Disruption 67 63.08 Quite High
INFLAMMATION 4 29.60 Quite Low
Overdose 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Introducing the stop codon after uAUG#3 either alone (uAUG#3 +S) or in combination with a stop codon inserted after uAUG#2 (uAUG#2, 3 +S) increased LUC activity by about 1.5- and 1.7-fold, respectively (Figure 5B).
Positive_regulation (increased) of LUC
1) Confidence 0.26 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.33 Pain Relevance 0.04
M + S constructs also increased LUC activity to a greater degree than that observed with the uAUG#3 M + S construct (Figure 5D).
Positive_regulation (increased) of LUC
2) Confidence 0.26 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.27 Pain Relevance 0.07
The third uAUG plus stop construct mutation (uAUG#3 M + S) increased LUC activity more than the uAUG#3 +S construct but did not affect the mRNA content.
Positive_regulation (increased) of LUC
3) Confidence 0.26 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.29 Pain Relevance 0.07
Particularly, mutations within the third uAUG or second/third uAUG (uAUG#3 or uAUG#2, 3) caused a 1.6- and 2.9-fold increase in LUC activity, respectively.
Positive_regulation (increase) of LUC
4) Confidence 0.23 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.26 Pain Relevance 0.14
It was initially expected that the two transgenes (CMV::luc and fos::luc), which were derived from different immediate-early genes, would display distinctly different expression patterns, although the two do have some common gene regulatory elements.
Positive_regulation (derived) of luc associated with cytomegalovirus infection
5) Confidence 0.19 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 1.17 Pain Relevance 0
Again, these increases in LUC activity were not caused by alterations in transcriptional activity.
Positive_regulation (increases) of LUC
6) Confidence 0.19 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.33 Pain Relevance 0.06
It was initially expected that the two transgenes (CMV::luc and fos::luc), which were derived from different immediate-early genes, would display distinctly different expression patterns, although the two do have some common gene regulatory elements.
Positive_regulation (derived) of luc associated with cytomegalovirus infection
7) Confidence 0.17 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 1.17 Pain Relevance 0
Our data establish that GABAergic regulation is a common mechanism across neural circadian clocks because blockade of GABA receptors in SCN explants also increases Per1::luc rhythmic amplitude [65], and application of GABA resets the phase of spike frequency rhythms in isolated SCN neurons [81].
Positive_regulation (increases) of luc in neural associated with gaba, gaba receptor and gabaergic
8) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.08 Pain Relevance 0.62
These data, along with our above-mentioned results demonstrating that retinal PER2::LUC rhythms persisted in the presence of TTX, form convergent lines of evidence suggesting that neither dopaminergic transmission nor its rhythmicity is necessary for ongoing retinal PER2::LUC circadian rhythms generation.
Positive_regulation (necessary) of LUC associated with tetrodotoxin
9) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.62
Therefore, sodium-dependent action potentials are not required for retinal PER2::LUC rhythms generation.
Neg (not) Positive_regulation (required) of LUC associated with action potential
10) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.25 Pain Relevance 0.69
We first examined whether dopamine is required for retinal PER2::LUC rhythms generation.
Spec (whether) Positive_regulation (required) of LUC associated with dopamine
11) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.06 Pain Relevance 0.43
Our finding that PER2::LUC rhythms persist in C57BL/6J mouse retinas with genetically blunted melatonin production and following pharmacological manipulation of melatonin signaling is consistent with previous studies showing that melatonin is not required for circadian photoreceptor disk shedding in constant darkness [4], and that photoreceptors, the primary source of retinal melatonin, are not required for retinal PER2::LUC rhythms generation [43].
Neg (not) Positive_regulation (required) of LUC in photoreceptors
12) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.27
In this case, the first peak of the ongoing PER2::LUC rhythms occurred ca. 14 h after the media change, not ca. 22 h after, as when GABA was washed out (n = 3).
Positive_regulation (ongoing) of LUC associated with gaba
13) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.44
Continuous recordings of PER2::LUC activity were made from 12 slices for up to 14 days in vitro.
Positive_regulation (made) of LUC
14) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.24 Pain Relevance 0
Oscillations of PER2::LUC bioluminescence in the SCN were of significantly higher amplitude than either micro-dissected DMH or Arc complex, or intact MBH cultures (SCN mean amplitude: 5426 ± 1215, relative bioluminescence; all p < 0.0001; ANOVA with a priori single degree of freedom comparisons; Table 1).
Positive_regulation (Oscillations) of LUC associated with aids-related complex
15) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.37 Pain Relevance 0.06
Continuous recordings of PER2::LUC activity were made from 11 slices for up to 10 days in vitro.
Positive_regulation (made) of LUC
16) Confidence 0.02 Published 2010 Journal Neuroscience Section Body Doc Link PMC2928449 Disease Relevance 0 Pain Relevance 0

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