INT174675

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Context Info
Confidence 0.18
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.09
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Luc7l3) mRNA processing (Luc7l3) plasma membrane (Luc7l3)
nucleus (Luc7l3) DNA binding (Luc7l3) response to stress (Luc7l3)
Anatomy Link Frequency
retina 1
brain 1
internal 1
skin 1
Luc7l3 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 52 99.98 Very High Very High Very High
gABA 516 99.82 Very High Very High Very High
mu opioid receptor 84 98.40 Very High Very High Very High
imagery 159 84.40 Quite High
GABA receptor 36 84.24 Quite High
agonist 113 72.56 Quite High
antagonist 113 68.36 Quite High
dopamine receptor 16 59.04 Quite High
addiction 12 51.72 Quite High
Dopamine 300 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 264 100.00 Very High Very High Very High
Repression 8 100.00 Very High Very High Very High
Overdose 42 98.88 Very High Very High Very High
Targeted Disruption 76 73.92 Quite High
Sprains And Strains 6 70.96 Quite High
Contagious Ecthyma 14 70.16 Quite High
Stress 12 6.28 Low Low
INFLAMMATION 6 5.64 Low Low
Ganglion Cysts 104 5.00 Very Low Very Low Very Low
Viral Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A volume of 0.1 ml provided bioluminescence images of the skin, brain, and internal structures in adult CMV::luc and fos::luc mice after an overdose with pentobarbital (Fig. 1, 2).
Negative_regulation (provided) of luc in skin associated with cytomegalovirus infection and overdose
1) Confidence 0.18 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.59 Pain Relevance 0.08
These results suggest that the repression of the LUC activity is due to the presence of the MOR 5?
Negative_regulation (repression) of LUC associated with repression and mu opioid receptor
2) Confidence 0.16 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.31 Pain Relevance 0.13
A volume of 0.1 ml provided bioluminescence images of the skin, brain, and internal structures in adult CMV::luc and fos::luc mice after an overdose with pentobarbital (Fig. 1, 2).
Negative_regulation (provided) of luc in brain associated with cytomegalovirus infection and overdose
3) Confidence 0.06 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.59 Pain Relevance 0.08
A volume of 0.1 ml provided bioluminescence images of the skin, brain, and internal structures in adult CMV::luc and fos::luc mice after an overdose with pentobarbital (Fig. 1, 2).
Negative_regulation (provided) of luc in internal associated with cytomegalovirus infection and overdose
4) Confidence 0.06 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.59 Pain Relevance 0.08
In contrast, if the observed suppression of PER2::LUC luminescence rhythms during GABA application did not have an effect on the core clock, but merely on luminescence output, then the phase of restored rhythms should be predicted by the projected phase of the baseline rhythm obtained prior to treatment.
Negative_regulation (suppression) of LUC associated with gaba
5) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.41
To further test whether GABAergic suppression of PER2::LUC luminescence rhythms results from an effect on the core function of the retinal clock, we tested whether prolonged application of GABA can halt the molecular oscillation of the retinal clock.
Spec (whether) Negative_regulation (suppression) of LUC associated with gaba and gabaergic
6) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.48
At 2 mM or 3 mM, GABA further inhibited PER2::LUC luminescence levels and resulted in rapid damping of PER2::LUC rhythms (Figure 7C and 7D).
Negative_regulation (inhibited) of LUC associated with gaba
7) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.58
Therefore, GABA-induced inhibition of ensemble PER2::LUC rhythms is retina specific.


Negative_regulation (inhibition) of LUC in retina associated with gaba
8) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.81

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