INT174683

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.95
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
microglia 4
monocytes 1
Astrocytes 1
lung 1
kidney 1
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 124 100.00 Very High Very High Very High
ischemia 12 97.48 Very High Very High Very High
cva 3 95.68 Very High Very High Very High
Hippocampus 8 95.12 Very High Very High Very High
Inflammatory response 28 94.88 High High
Paracetamol 25 93.36 High High
Central nervous system 39 92.28 High High
cytokine 151 86.32 High High
COX-2 inhibitor 4 84.12 Quite High
chemokine 42 68.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 159 100.00 Very High Very High Very High
Cv Unclassified Under Development 12 97.48 Very High Very High Very High
Atherosclerosis 7 96.80 Very High Very High Very High
Disease 302 96.76 Very High Very High Very High
Injury 159 96.40 Very High Very High Very High
Hemorrhage 3 95.68 Very High Very High Very High
Edema 2 94.72 High High
Infection 72 94.64 High High
Pneumonia 4 94.28 High High
Hepatotoxicity 1 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study has shown that mRNA and protein levels of TLR2 and TLR4 in circulating monocytes were higher in patients with AMI prior to PCI than in patients with SA and controls.
Transcription (levels) of TLR2 in monocytes
1) Confidence 0.58 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.92 Pain Relevance 0.04
Reverse transcription-generated cDNA encoding TLR2, TLR4, and TNF?
Transcription (transcription) of TLR2
2) Confidence 0.49 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.14 Pain Relevance 0
Another study reported, in support of our observations, that selective pharmacological inhibition of COX-2 with NS-398 increases the transcription of inflammatory genes (mPGES-1, TLR2, CD14, MCP-1) in vascular associated brain cells and parenchymal microglia after systemic injection of LPS [14].
Transcription (transcription) of TLR2 in microglia associated with inflammation
3) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.90 Pain Relevance 0.36
In the kidney, the majority of the constitutive TLR2 and TLR4 mRNA is expressed by tubular epithelial cells (TECs) and is enhanced upon renal ischemia/reperfusion (I/R) injury as shown by in situ hybridization [14].
Transcription (expressed) of TLR2 in kidney associated with ischemia and injury
4) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.52 Pain Relevance 0.16
up-regulated TLRs, transcription of TLR1,TLR2,TLR3,TLR5,TLR8, and TLR10 was significantly down-regulated in similarly treated AD cells.
Transcription (transcription) of TLR2 associated with disease
5) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604897 Disease Relevance 0.88 Pain Relevance 0.09
The mRNA expression for TLR2 and TLR4 in the lung is increased by the combined exposure to washed DEP + LPS.
Transcription (expression) of TLR2 in lung
6) Confidence 0.33 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0.45 Pain Relevance 0.16
42 plus LPS induction of MyD88, CD14, and TLR2 mRNA expression in microglia.
Transcription (expression) of TLR2 in microglia
7) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.82 Pain Relevance 0.08
Plaque-associated microglia exhibit elevated mRNA levels for TLR2, 4, 5, 7, 9 [87] (Figure 1).
Transcription (levels) of TLR2 in microglia
8) Confidence 0.28 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.80 Pain Relevance 0.14
Astrocytes and oligodendrocytes express mRNA for TLR2 that recognizes fungal, gram-positive and mycobacterial components and TLR3 that recognize double-stranded RNA.
Transcription (express) of TLR2 in oligodendrocytes
9) Confidence 0.22 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.15 Pain Relevance 0.14
RIa and CR3 considerably, but had no effect on GAPDH, TLR2 or TLR4 mRNA transcript levels (Figure 3A).
Transcription (levels) of TLR2
10) Confidence 0.19 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0.05 Pain Relevance 0
MyD88, TLR2, and TLR4 mRNA expression in primary microglia were
Transcription (expression) of TLR2 in microglia
11) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.18 Pain Relevance 0.09
Astrocytes and oligodendrocytes express mRNA for TLR2 that recognizes fungal, gram-positive and mycobacterial components and TLR3 that recognize double-stranded RNA.
Transcription (express) of TLR2 in Astrocytes
12) Confidence 0.07 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.15 Pain Relevance 0.14

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