INT174687

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 9.07
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 2
osteoblasts 2
hippocampus 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 168 100.00 Very High Very High Very High
Paracetamol 12 99.88 Very High Very High Very High
Hippocampus 26 99.68 Very High Very High Very High
Osteoarthritis 108 97.72 Very High Very High Very High
Inflammation 272 97.40 Very High Very High Very High
chemokine 34 94.92 High High
Inflammatory response 42 94.24 High High
imagery 19 88.92 High High
tolerance 5 83.76 Quite High
rheumatoid arthritis 8 68.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 217 100.00 Very High Very High Very High
Aging 23 99.84 Very High Very High Very High
Ocular Injury 29 99.68 Very High Very High Very High
Reprotox - General 1 2 99.68 Very High Very High Very High
Pulmonary Disease 9 98.20 Very High Very High Very High
Osteoarthritis 86 97.72 Very High Very High Very High
Primary Pulmonary Hypertension 48 97.72 Very High Very High Very High
INFLAMMATION 327 97.40 Very High Very High Very High
Crystal Associated Disease 30 96.84 Very High Very High Very High
Metabolic Bone Disease 1 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Factors responsible for peripheral IL-6 induction in aging humans include diet, hormone status, activity, and genetics[2], [3], [5], [46], [47], and while mechanisms which increase IL-6 in the nervous system are less well understood, direct entry of plasma IL-6 into brain has been shown[12].
Regulation (responsible) of Positive_regulation (induction) of IL-6 in plasma associated with aging
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.28 Pain Relevance 0.04
This polymorphism influences the levels of circulating IL-6, suggesting a causal role for high circulating IL-6 levels in the pathogenesis of PH in patients with COPD.
Regulation (role) of Positive_regulation (circulating) of IL-6 associated with pulmonary disease and primary pulmonary hypertension
2) Confidence 0.45 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.63 Pain Relevance 0.31
underlying mechanism of induction of IL-6 by patientsÂ’ serum is not known and
Regulation (mechanism) of Positive_regulation (induction) of IL-6
3) Confidence 0.36 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276911 Disease Relevance 0.71 Pain Relevance 0.07
The reciprocal regulation of MSC conditioning on stimulated Skov-3 tumor showed increases in IL-6, TGF-?
Regulation (regulation) of Positive_regulation (increases) of IL-6 associated with cancer
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.52 Pain Relevance 0
-triggered increase in IL-6, MIP-1?
Regulation (triggered) of Positive_regulation (increase) of IL-6
5) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864766 Disease Relevance 1.32 Pain Relevance 0.51
BMSC exposed to NGF or BDNF demonstrate increases in IL-6 protein consistent with gene expression changes
Regulation (demonstrate) of Positive_regulation (increases) of IL-6 protein
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.09 Pain Relevance 0.03
To further investigate the role of ERK1/2 and p38 pathway in neurotrophin induction of IL-6, specific inhibitors targeting both pathways were utilized as discussed in methods.
Spec (investigate) Regulation (role) of Positive_regulation (induction) of IL-6
7) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0
mRNA expression and a 15-fold increase in IL-6 in the hippocampus at six hours after LPS injection (Figures 1e and 1f; P < 0.001 vs control).
Regulation (fold) of Positive_regulation (increase) of IL-6 in hippocampus associated with hippocampus
8) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.32 Pain Relevance 0.30
Acetaminophen also interferes with IL-6 [44] levels as well as the release of TNF?
Regulation (interferes) of Positive_regulation (levels) of IL-6 associated with paracetamol
9) Confidence 0.18 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.41 Pain Relevance 0.53
On the other hand, increased leptin levels are associated with increased concentrations of other proinflammatory cytokines such as IL-1, IL-6, IL-8, TNF?
Regulation (associated) of Positive_regulation (increased) of IL-6 associated with cytokine
10) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 1.76 Pain Relevance 0.55
These results raise questions whether IL-6 is locally induced following a penetrating ocular injury and whether an increased level of IL-6 is involved in the abortion of ACAID.
Spec (whether) Regulation (involved) of Spec (whether) Positive_regulation (increased) of IL-6 associated with ocular injury and reprotox - general 1
11) Confidence 0.17 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.69 Pain Relevance 0.11
Considering the short half-life of IL-6 mRNA and strong role of mRNA stabilization in regulation of IL-6 expression [29,30], another possible explanation is that the root extracts increased turnover of IL-6 mRNA, whereas the stability of the IL-6 protein was unaffected.
Spec (possible) Regulation (role) of Positive_regulation (stabilization) of IL-6 mRNA
12) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.43 Pain Relevance 0.08
induced IL-6 expression by CMT-8 in murine osteoblasts at a post-transcriptional level affecting the stability of IL-6 mRNA, provides potential for new incentives for therapeutic management of IL-6 mediated metabolic bone diseases [74].


Regulation (affecting) of Positive_regulation (stability) of IL-6 in osteoblasts associated with metabolic bone disease
13) Confidence 0.03 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 0.91 Pain Relevance 0.07

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