INT174688

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 45
Total Number 47
Disease Relevance 36.65
Pain Relevance 5.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
dendritic cells 3
bone marrow 2
alveolar macrophages 1
kidney 1
coronary artery 1
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 153 99.74 Very High Very High Very High
Inflammation 838 99.60 Very High Very High Very High
cytokine 577 98.16 Very High Very High Very High
Arthritis 38 98.08 Very High Very High Very High
fibrosis 159 96.88 Very High Very High Very High
antagonist 54 95.96 Very High Very High Very High
metalloproteinase 130 93.48 High High
Central nervous system 40 91.60 High High
Inflammatory mediators 26 91.20 High High
ischemia 137 90.56 High High
Disease Link Frequency Relevance Heat
Hydronephrosis 308 100.00 Very High Very High Very High
Aging 104 99.92 Very High Very High Very High
INFLAMMATION 974 99.60 Very High Very High Very High
Atherosclerosis 156 99.56 Very High Very High Very High
Cancer 1095 99.48 Very High Very High Very High
Lyme Disease 26 99.38 Very High Very High Very High
Systemic Lupus Erythematosus 106 99.22 Very High Very High Very High
Rhinitis 2 99.16 Very High Very High Very High
Hemophilus Infection 89 98.80 Very High Very High Very High
Injury 861 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, there are data demonstrating that HMGB1 can be secreted from cells and can leak into the urine [34] making it possible to interact with apical TLR2.
TLR2 Spec (possible) Binding (interact) of in urine associated with hydronephrosis
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.86 Pain Relevance 0.04
Although cytoplasmic HMGB1 was only faintly found, it could as well interact with cytoplasmic TLR2.
TLR2 Binding (interact) of associated with hydronephrosis
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.80 Pain Relevance 0.04
TLR2 normally activates dendritic cells by binding to specific proteins on invading pathogens, so what was TLR2 binding to in the mouse tumors?
TLR2 Binding (binding) of in dendritic cells associated with cancer
3) Confidence 0.41 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.25 Pain Relevance 0
Of particular interest is the finding that TLR2?
TLR2 Binding (finding) of associated with hydronephrosis
4) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.80 Pain Relevance 0.19
Most interestingly, TLRs, including TLR2, also recognize endogenous danger molecules that have been altered from their native state or accumulate in non-physiologic sites or amounts during cellular injury [13]–[22].
TLR2 Binding (recognize) of associated with injury
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.35 Pain Relevance 0.31
Herein we uncovered a novel pathway for the activation of an effective anti-GBM immune response mediated by high-mobility-group box 1 (HMGB1), an alarmin protein released from dying tumor cells, which acts as an endogenous ligand for Toll-like receptor 2 (TLR2) signaling on bone marrow-derived GBM-infiltrating DCs.


TLR2 Binding (ligand) of in bone marrow associated with cancer and glioblastoma
6) Confidence 0.35 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.26 Pain Relevance 0.05
TLR2 normally activates dendritic cells by binding to specific proteins on invading pathogens, so what was TLR2 binding to in the mouse tumors?
TLR2 Binding (binding) of in dendritic cells associated with cancer
7) Confidence 0.35 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.29 Pain Relevance 0
Herein we uncovered a novel pathway for the activation of an effective anti-GBM immune response mediated by high-mobility-group box 1 (HMGB1), an alarmin protein released from dying tumor cells, which acts as an endogenous ligand for Toll-like receptor 2 (TLR2) signaling on bone marrow-derived GBM-infiltrating DCs.


Toll-like receptor 2 Binding (ligand) of in bone marrow associated with cancer and glioblastoma
8) Confidence 0.35 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.21 Pain Relevance 0.05
TLR2 and TLR4, have been shown to be essential for the recognition of distinct bacterial cell wall components.
TLR2 Binding (recognition) of
9) Confidence 0.34 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.88 Pain Relevance 0.17
Notably, induction of type 1 interferon in inflammatory monocytes required internalization of TLR2.
TLR2 Binding (internalization) of in inflammatory monocytes associated with inflammation
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.42 Pain Relevance 0.16
Since toll-like receptors (TLRs), particularly TLR2 and TLR4, have been demonstrated to recognize endogenous ligands, including DAMPs, as well as microbial components [1], [3], [14], we examined TLR2 and TLR4 signaling for their involvement in the protection afforded by administration of rhBCL2 or rhBCL2A1.
TLR2 Spec (examined) Binding (recognize) of
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.22 Pain Relevance 0.07
Among of 11 mammalian TLRs, TLR2 is recognized as an important receptor for NTHi-induced signaling pathway in lung epithelial cells.
TLR2 Binding (recognized) of in epithelial cells associated with hemophilus infection
12) Confidence 0.31 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.91 Pain Relevance 0.04
TLR2 normally activates dendritic cells by binding to specific proteins on invading pathogens, so what was TLR2 binding to in the mouse tumors?
TLR2 Binding (binding) of in dendritic cells associated with cancer
13) Confidence 0.31 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.23 Pain Relevance 0
Together, these data suggest a potential role for renal TLR2 and TLR4 in the primary mechanism through which the kidney monitors renal injury and initiates and regulates inflammation.
TLR2 Binding (role) of in kidney associated with inflammation and injury
14) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.68 Pain Relevance 0.09
Shishido et al. [74] used TLR2-deficient mice with coronary artery ligation and followed them for 4 weeks.
TLR2 Binding (ligation) of in coronary artery
15) Confidence 0.30 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 1.00 Pain Relevance 0.22
The resulting TLR1/TLR2 and TLR6/TLR2 complexes recognize distinct ligands, triacyl and diacyl lipoproteins, respectively.
TLR2 Binding (recognize) of
16) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.79 Pain Relevance 0.05
First, there may be an intermediate effector cell in vivo that then elaborates an endogenous TLR2 ligand(s) in response to stimulation by rhBCL2A1 or rhBCL2.
TLR2 Binding (ligand) of
17) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.42 Pain Relevance 0.11
The published sequences for human TLR2 (forward primer, 5?
TLR2 Binding (primer) of
18) Confidence 0.27 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0 Pain Relevance 0
In another experiment, the lung tissue was harvested for the assay of TLR2, TLR4, and TNF?
TLR2 Binding (assay) of in lung
19) Confidence 0.26 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.55 Pain Relevance 0.14
interacted with CD14 (TLR2 and TLR4 accessory protein) and was phagocytosed by cultured microglia and monocytes, resulting in activation of the cells as well as increased secretion of cytokines [38,39].
TLR2 Binding (interacted) of in monocytes associated with cytokine
20) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.27 Pain Relevance 0.25

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