INT174689

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 8.24
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7)
plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)
Anatomy Link Frequency
Langerhans cells 1
T cells 1
Microglia 1
Tlr7 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 68 99.92 Very High Very High Very High
Inflammation 216 99.20 Very High Very High Very High
cytokine 291 98.24 Very High Very High Very High
Inflammatory response 14 92.72 High High
tolerance 14 87.28 High High
Central nervous system 50 86.28 High High
chemokine 35 85.68 High High
fibrosis 1 55.32 Quite High
cINOD 6 48.88 Quite Low
corticosteroid 2 47.20 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 68 99.92 Very High Very High Very High
INFLAMMATION 220 99.20 Very High Very High Very High
Targeted Disruption 13 98.90 Very High Very High Very High
Genetic Translocation 2 97.44 Very High Very High Very High
Renal Disease 6 96.92 Very High Very High Very High
Disease 118 95.80 Very High Very High Very High
Systemic Lupus Erythematosus 153 95.76 Very High Very High Very High
Influenza Virus Infection 528 93.32 High High
Infection 205 88.64 High High
Cancer 110 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the expression of TLR7 was observed in keratinocytes and in certain lineages of dendritic cells but not in the Langerhans cells [42], [43], indicating that the TLR7 signaling pathway is not the main contributor for activating skin resident Langerhans cells.
Gene_expression (expression) of TLR7 in Langerhans cells
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.45 Pain Relevance 0
production from CD8+ T cells, TLR7 has been implicated in the IFN-?
Gene_expression (production) of TLR7 in T cells
2) Confidence 0.43 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.87 Pain Relevance 0
Transgenic analysis of TLR7 determined that a modest increase in TLR7 expression resulted in spontaneous development of autoimmunity and a substantial increase in TLR7 expression caused fatal acute inflammation and profound DC dysregulation, indicating that TLR7 must be tightly regulated in order to prevent spontaneous triggering of harmful autoreactive and inflammatory responses [171].
Gene_expression (expression) of TLR7 associated with targeted disruption, inflammatory response, autoimmune disease and inflammation
3) Confidence 0.43 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.91 Pain Relevance 0.23
Transgenic analysis of TLR7 determined that a modest increase in TLR7 expression resulted in spontaneous development of autoimmunity and a substantial increase in TLR7 expression caused fatal acute inflammation and profound DC dysregulation, indicating that TLR7 must be tightly regulated in order to prevent spontaneous triggering of harmful autoreactive and inflammatory responses [171].
Gene_expression (expression) of TLR7 associated with targeted disruption, inflammatory response, autoimmune disease and inflammation
4) Confidence 0.43 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.92 Pain Relevance 0.23
Viral inhibition correlated with the ability of the TLR7/8 agonist to stimulate type I IFN and other cytokines such as TNF-?
Gene_expression (/) of TLR7 associated with agonist and cytokine
5) Confidence 0.37 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.63 Pain Relevance 0.33
levels after TLR7 stimulation than did PBMCs isolated from males although there was no difference in TNF-?
Gene_expression (stimulation) of TLR7
6) Confidence 0.37 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 1.01 Pain Relevance 0.12
For example, freshly isolated human pDCs express TLR7 and 9, whereas mDCs express TLR1, 2, 3, 5, 6, and 8 [26-28].
Gene_expression (express) of TLR7
7) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.11
TLR7, 8, and TLR9 expressed by pDCs respond to self-RNA and -DNA respectively when coupled with the endogenous antimicrobial peptide LL37 [91, 92].
Gene_expression (expressed) of TLR7
8) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.17 Pain Relevance 0
B16 cells also expressed other members of the TLR family including TLR1, TLR3, TLR5, TLR6 and TLR7 (Figure S1C).
Gene_expression (expressed) of TLR7
9) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.96 Pain Relevance 0.14
For example, freshly isolated human pDCs express TLR7 and 9, whereas mDCs express TLR1, 2, 3, 5, 6, and 8 [26-28].
Gene_expression (express) of TLR7
10) Confidence 0.23 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0 Pain Relevance 0.11
Microglia cells express mRNA for a wide range of TLR family members (TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8 and TLR9) much like other cells of the monocytic lineage [49].
Spec (like) Gene_expression (express) of TLR7 in Microglia
11) Confidence 0.18 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.38 Pain Relevance 0.13
Several subsequent studies have shown that the reason for the male bias in these mice was due to an X-to-Y chromosomal translocation of a gene cluster known as Y autoimmune accelerator (Yaa) and that the primary contributor to this accelerated autoimmunity is TLR 7 overexpression [16, 17].
Gene_expression (overexpression) of TLR 7 associated with autoimmune disease and genetic translocation
12) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 1.00 Pain Relevance 0.07
Pawar et al. used IRS sequences as TLR 7 and 9 inhibitors in MRLlpr/lpr mice and showed a reduction in inflammatory cytokine levels and autoantibody titers, as well as a decrease in resulting tissue damage [84].
Gene_expression (sequences) of TLR 7 associated with inflammation and cytokine
13) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.95 Pain Relevance 0.10

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