INT174699

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.66
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2, Tlr3) intracellular (Tlr2, Tlr3) cytoplasm (Tlr2, Tlr3)
endosome (Tlr3) endoplasmic reticulum (Tlr3) RNA binding (Tlr3)
Anatomy Link Frequency
Astrocytes 1
oligodendrocytes 1
Tlr2 (Mus musculus)
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 77 98.40 Very High Very High Very High
Central nervous system 8 91.60 High High
cytokine 58 75.36 Quite High
chemokine 19 74.48 Quite High
aspirin 4 24.00 Low Low
Paracetamol 25 23.28 Low Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
vagus nerve 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 5 99.28 Very High Very High Very High
INFLAMMATION 79 98.40 Very High Very High Very High
Viral Infection 1 96.88 Very High Very High Very High
Infection 30 93.96 High High
Syndrome 3 62.72 Quite High
Fever 68 56.56 Quite High
Autism 46 50.00 Quite Low
Febrile Convulsions 2 48.32 Quite Low
Coma 2 46.88 Quite Low
Targeted Disruption 6 46.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to TLR2, TLR3 was also shown to recognize cells undergoing necrosis during acute inflammatory events, independently of viral infection [39].
TLR2 Binding (recognize) of TLR3 associated with necrosis, inflammation and viral infection
1) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.36 Pain Relevance 0.05
Astrocytes and oligodendrocytes express mRNA for TLR2 that recognizes fungal, gram-positive and mycobacterial components and TLR3 that recognize double-stranded RNA.
TLR2 Binding (recognizes) of TLR3 in oligodendrocytes
2) Confidence 0.05 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.15 Pain Relevance 0.15
Astrocytes and oligodendrocytes express mRNA for TLR2 that recognizes fungal, gram-positive and mycobacterial components and TLR3 that recognize double-stranded RNA.
TLR2 Binding (recognizes) of TLR3 in Astrocytes
3) Confidence 0.02 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.15 Pain Relevance 0.15

General Comments

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