INT17470

Context Info Confidence 0.05 First Reported 1991 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 4 Disease Relevance 3.43 Pain Relevance 0.75

transport (NDUFC1) mitochondrion (NDUFC1) small molecule metabolic process (NDUFC1)

Anatomy Link Frequency RVLM 1 respiratory 1 NDUFC1 (Homo sapiens)

Pain Link Frequency Relevance Heat Substantia nigra 20 93.80 depression 3 93.64 Rostral ventrolateral medulla 7 92.04 anesthesia 1 87.48 Migraine 2 80.48 cva 1 50.40 Neuritis 2 41.12 Multiple sclerosis 5 40.08 Dopamine 6 35.28 ketamine 1 5.00

Disease Link Frequency Relevance Heat Disease 37 99.04 Stress 12 99.00 Parkinson's Disease 5 98.16 Mitochondrial Encephalomyopathies 1 95.96 Endotoxemia 4 94.92 Lactic Acidosis 1 94.44 Cardiovascular Disorder Under Development 3 93.64 Stroke 1 93.64 Syndrome 2 92.52 Neurodegenerative Disease 1 89.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A 24-year-old male had a deficiency of the complex I (NADH coenzyme-Q-reductase) of the mitochondrial respiratory chain, which clinically presented as a mitochondrial encephalomyopathy, with lactic acidosis and stroke-like episodes (MELAS syndrome).

Spec (like) Negative_regulation (deficiency) of complex I in respiratory associated with lactic acidosis, syndrome, stroke and mitochondrial encephalomyopathies

1) Confidence 0.05 Published 1991 Journal Neurologia Section Abstract Doc Link 1908255 Disease Relevance 0.97 Pain Relevance 0.16

They have also used the yeast NDI1 to rescue complex I deficiency in a mutant ND4 cell line [34].

Negative_regulation (deficiency) of complex I

2) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 0.67 Pain Relevance 0

Mitochondrial complex I function is impaired early in the course of PD [3], and pharmacological inhibitors of complex I lead to some of the features of PD in animal models [4], [5], suggesting that mitochondrial complex I deficiency may play a role in the pathogenesis of PD.

Negative_regulation (impaired) of complex I associated with disease

3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.98 Pain Relevance 0.15

LPS also induced nitric oxide (NO) and superoxide (O(2)(-)) production, depressed mitochondrial Complex I and IV activity, promoted the release of cytochrome c from mitochondria to cytosol, upregulated the cytosolic expression of activated caspase-9 and -3, or increased caspase-3 enzyme activity in the RVLM.

Negative_regulation (depressed) of Complex I in RVLM associated with rostral ventrolateral medulla

4) Confidence 0.00 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16085179 Disease Relevance 0.81 Pain Relevance 0.44

General Comments

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