INT17470

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Context Info
Confidence 0.05
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.43
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (NDUFC1) mitochondrion (NDUFC1) small molecule metabolic process (NDUFC1)
Anatomy Link Frequency
RVLM 1
respiratory 1
NDUFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 20 93.80 High High
depression 3 93.64 High High
Rostral ventrolateral medulla 7 92.04 High High
anesthesia 1 87.48 High High
Migraine 2 80.48 Quite High
cva 1 50.40 Quite High
Neuritis 2 41.12 Quite Low
Multiple sclerosis 5 40.08 Quite Low
Dopamine 6 35.28 Quite Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 37 99.04 Very High Very High Very High
Stress 12 99.00 Very High Very High Very High
Parkinson's Disease 5 98.16 Very High Very High Very High
Mitochondrial Encephalomyopathies 1 95.96 Very High Very High Very High
Endotoxemia 4 94.92 High High
Lactic Acidosis 1 94.44 High High
Cardiovascular Disorder Under Development 3 93.64 High High
Stroke 1 93.64 High High
Syndrome 2 92.52 High High
Neurodegenerative Disease 1 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 24-year-old male had a deficiency of the complex I (NADH coenzyme-Q-reductase) of the mitochondrial respiratory chain, which clinically presented as a mitochondrial encephalomyopathy, with lactic acidosis and stroke-like episodes (MELAS syndrome).
Spec (like) Negative_regulation (deficiency) of complex I in respiratory associated with lactic acidosis, syndrome, stroke and mitochondrial encephalomyopathies
1) Confidence 0.05 Published 1991 Journal Neurologia Section Abstract Doc Link 1908255 Disease Relevance 0.97 Pain Relevance 0.16
They have also used the yeast NDI1 to rescue complex I deficiency in a mutant ND4 cell line [34].
Negative_regulation (deficiency) of complex I
2) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 0.67 Pain Relevance 0
Mitochondrial complex I function is impaired early in the course of PD [3], and pharmacological inhibitors of complex I lead to some of the features of PD in animal models [4], [5], suggesting that mitochondrial complex I deficiency may play a role in the pathogenesis of PD.
Negative_regulation (impaired) of complex I associated with disease
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.98 Pain Relevance 0.15
LPS also induced nitric oxide (NO) and superoxide (O(2)(-)) production, depressed mitochondrial Complex I and IV activity, promoted the release of cytochrome c from mitochondria to cytosol, upregulated the cytosolic expression of activated caspase-9 and -3, or increased caspase-3 enzyme activity in the RVLM.
Negative_regulation (depressed) of Complex I in RVLM associated with rostral ventrolateral medulla
4) Confidence 0.00 Published 2005 Journal Free Radic. Biol. Med. Section Abstract Doc Link 16085179 Disease Relevance 0.81 Pain Relevance 0.44

General Comments

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