INT174711

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Context Info
Confidence 0.02
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
Hspa5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 15 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
Limbic system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 48 95.92 Very High Very High Very High
Drug Induced Neurotoxicity 57 85.20 High High
Injury 3 47.64 Quite Low
Toxicity 12 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Anxiety Disorder 9 5.00 Very Low Very Low Very Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Malaria 6 5.00 Very Low Very Low Very Low
Dizziness 6 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcription of key ER proteins including GADD153, PERK, GRP78, PDI, GRP94 and calreticulin were up-regulated by mefloquine, suggesting that the drug induced an ER stress response.
Transcription (transcription) of GRP78 associated with stress
1) Confidence 0.02 Published 2003 Journal Malar J Section Abstract Doc Link PMC194860 Disease Relevance 0.61 Pain Relevance 0
The ability of mefloquine to upregulate the transcription of PDI, GRP78, GRP94 and calreticulin is consistent with this hypothesis.
Transcription (transcription) of GRP78
2) Confidence 0.02 Published 2003 Journal Malar J Section Body Doc Link PMC194860 Disease Relevance 0 Pain Relevance 0
M) upregulated the transcription of four of five ER resident chaperones, GRP78, PDI, GRP94 and calreticulin, GADD153 and PERK (one way ANOVA P < 0.05, n = 20, FC > 1.3, Table 2).
Transcription (transcription) of GRP78
3) Confidence 0.01 Published 2003 Journal Malar J Section Body Doc Link PMC194860 Disease Relevance 0.09 Pain Relevance 0

General Comments

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