INT174724

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Context Info
Confidence 0.18
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 5 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Codeine 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
tramadol 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 99.96 Very High Very High Very High
Cancer 12 99.68 Very High Very High Very High
Disease 32 72.48 Quite High
Injury 1 60.60 Quite High
Breast Cancer 3 56.44 Quite High
Drug Induced Neurotoxicity 19 50.00 Quite Low
Targeted Disruption 1 33.04 Quite Low
Toxicity 8 5.00 Very Low Very Low Very Low
Lung Cancer 7 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of ER, the reason is that the protein stability but not the mRNA expression determines the levels of the ER in the tumour cells and thus the ER status of the tumors [130].
Spec (determines) Regulation (determines) of Transcription (expression) of ER associated with cancer
1) Confidence 0.18 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.33 Pain Relevance 0
Mefloquine upregulates the transcription of important ER stress response genes
Regulation (important) of Transcription (transcription) of ER associated with stress
2) Confidence 0.02 Published 2003 Journal Malar J Section Body Doc Link PMC194860 Disease Relevance 0.16 Pain Relevance 0

General Comments

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