INT174727

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 6.30
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
leukocyte 2
nucleus 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 18 100.00 Very High Very High Very High
Oxycodone 16 99.84 Very High Very High Very High
agonist 69 99.26 Very High Very High Very High
Opioid 113 99.04 Very High Very High Very High
Inflammation 7 97.88 Very High Very High Very High
aspirin 2 96.48 Very High Very High Very High
Eae 6 96.16 Very High Very High Very High
Analgesic 28 94.64 High High
Dopamine 26 92.80 High High
Opioid rotation 1 91.56 High High
Disease Link Frequency Relevance Heat
Reprotox - General 3 2 99.98 Very High Very High Very High
INFLAMMATION 9 97.88 Very High Very High Very High
Breast Cancer 178 97.60 Very High Very High Very High
Apoptosis 11 96.88 Very High Very High Very High
Hot Flashes 14 96.48 Very High Very High Very High
Increased Venous Pressure Under Development 19 95.32 Very High Very High Very High
Cancer 279 95.20 Very High Very High Very High
Uterine Cancer 1 93.60 High High
Brucella Infection 91 93.52 High High
Fever 13 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For opioid conversion to oxymorphone ER, oxycodone ER and morphine ER may be calculated to be equipotent and half as potent as oxymorphone ER, respectively (Sloan et al 2005).
Positive_regulation (calculated) of Positive_regulation (morphine) of ER associated with oxycodone, opioid and morphine
1) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 0.26 Pain Relevance 1.60
Rising agglutination titer was not associated with rising leukocyte count, while increasing titer correlated with increasing ESR (p = 0.01) (figure 2).
Positive_regulation (increasing) of Positive_regulation (increasing) of ESR in leukocyte
2) Confidence 0.42 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3004911 Disease Relevance 1.34 Pain Relevance 0
However, drop-out rates were high in both the simvastatin and ER niacin–simvastatin treatment groups in both the 24- and 52-week studies.
Positive_regulation (high) of Positive_regulation (groups) of ER
3) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2672455 Disease Relevance 0.73 Pain Relevance 0.10
Furthermore, we have provided evidence of ER mediated increase in TRPM8 mRNA expression.
Positive_regulation (mediated) of Positive_regulation (increase) of ER
4) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.42 Pain Relevance 0.04
Evidence also exists on ER activation by a
Positive_regulation (on) of Positive_regulation (activation) of ER
5) Confidence 0.27 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.49 Pain Relevance 0.04
Evidence also exists on ER activation by a
Positive_regulation (exists) of Positive_regulation (activation) of ER
6) Confidence 0.27 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.49 Pain Relevance 0.04
induction of progesterone receptors in the ventromedial nucleus.98 ER?
Positive_regulation (induction) of Positive_regulation (nucleus.98) of ER in nucleus
7) Confidence 0.17 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.05 Pain Relevance 0.05
, coumestrol might act by triggering ER?
Spec (might) Positive_regulation (act) of Positive_regulation (triggering) of ER
8) Confidence 0.17 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.09 Pain Relevance 0.11
agonists for HT to treat menopausal symptoms requires a greater understanding of the physiological roles of ER?
Positive_regulation (requires) of Positive_regulation (roles) of ER associated with reprotox - general 3 and agonist
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 1.06 Pain Relevance 0.28
-E2 could be mediated through a subpopulation of the classical estrogen receptor (ER), ER?
Positive_regulation (mediated) of Positive_regulation (subpopulation) of ER
10) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1201169 Disease Relevance 0 Pain Relevance 0.19
-E2 could be mediated through a subpopulation of the classical estrogen receptor (ER), ER?
Positive_regulation (mediated) of Positive_regulation (subpopulation) of ER
11) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1201169 Disease Relevance 0 Pain Relevance 0.19
is an essential regulator of the expression of PR [52], we conclude from these results that the IGF-I treatment caused increased activation of the MAPK cascade, resulting in increased activation of ER-?
Positive_regulation (resulting) of Positive_regulation (activation) of ER
12) Confidence 0.04 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.33 Pain Relevance 0
is an essential regulator of the expression of PR [52], we conclude from these results that the IGF-I treatment caused increased activation of the MAPK cascade, resulting in increased activation of ER-?
Positive_regulation (increased) of Positive_regulation (activation) of ER
13) Confidence 0.03 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.33 Pain Relevance 0
The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2?
Positive_regulation (leading) of Positive_regulation (upregulation) of ER associated with apoptosis
14) Confidence 0.02 Published 2003 Journal Malar J Section Body Doc Link PMC194860 Disease Relevance 0.50 Pain Relevance 0.08
However, we did find strong evidence for an increase in the growth promoting activity of mammary tissues from IGF-I-treated rats as compared with animals not receiving IGF-I treatment, in that the activity of the MAPK cascade was elevated with a concomitant increase in activation of ER-?.
Positive_regulation (increase) of Positive_regulation (activation) of ER
15) Confidence 0.02 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.20 Pain Relevance 0
Compromised ER function (induced by numerous stressors including depletion of ER calcium stores) may lead to the accumulation of unfolded proteins in the ER [11].
Spec (may) Positive_regulation (lead) of Positive_regulation (accumulation) of ER
16) Confidence 0.02 Published 2003 Journal Malar J Section Body Doc Link PMC194860 Disease Relevance 0 Pain Relevance 0

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