INT174753

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 13.82
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2)
extracellular space (Apoa2) extracellular region (Apoa2)
Anatomy Link Frequency
macrophages 1
Plasma 1
fat 1
apoptotic cells 1
Apoa2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 7 87.36 High High
dexamethasone 2 79.52 Quite High
cytokine 36 76.40 Quite High
Dismenorea 4 73.28 Quite High
cINOD 120 73.20 Quite High
Inflammation 99 61.56 Quite High
psoriasis 63 56.08 Quite High
corticosteroid 2 54.20 Quite High
imagery 4 46.56 Quite Low
alcohol 5 43.24 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 140 100.00 Very High Very High Very High
Metabolic Syndrome 65 100.00 Very High Very High Very High
Hyperlipidemia 29 100.00 Very High Very High Very High
Hyperglycemia 12 100.00 Very High Very High Very High
Hyperinsulinism 11 100.00 Very High Very High Very High
Apoptosis 82 99.84 Very High Very High Very High
Psoriasis 106 99.64 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 99.08 Very High Very High Very High
Coronary Artery Disease 130 98.68 Very High Very High Very High
Targeted Disruption 200 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, it appears to be a polygenic wild-type rodent (outbred) that expresses all aspects of the Metabolic Syndrome measured to date, including abdominal fat accumulation (at least in young rats), hyperinsulinemia, hyperglycemia, hypertriglyceridemia (with depressed HDL, unpublished data), microalbuminuria (data not shown), and hypertension on the way to terminal type 2 diabetes.
Gene_expression (expresses) of HDL in fat associated with hyperglycemia, pressure and volume under development, diabetes mellitus, hyperinsulinism, metabolic syndrome, hyperlipidemia and disorder of lipid metabolism
1) Confidence 0.75 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2868017 Disease Relevance 2.51 Pain Relevance 0
HDL-C : HDL cholesterol
Gene_expression (cholesterol) of HDL associated with disorder of lipid metabolism
2) Confidence 0.65 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.78 Pain Relevance 0
HDL-C : HDL cholesterol
Gene_expression (cholesterol) of HDL associated with disorder of lipid metabolism
3) Confidence 0.65 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.79 Pain Relevance 0
pressure, serum total cholesterol, logarithm of serum TG, HDL-C, LDL-C, age,
Gene_expression (logarithm) of HDL associated with disorder of lipid metabolism
4) Confidence 0.65 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.91 Pain Relevance 0
The latter is a key intermediate in cholesterol synthesis and aids in decreasing LDL cholesterol and increasing HDL cholesterol levels [239, 240].
Gene_expression (levels) of HDL associated with acquired immune deficiency syndrome or hiv infection and disorder of lipid metabolism
5) Confidence 0.65 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.49 Pain Relevance 0
Glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol, triglycerides, and HDL and LDL cholesterol were analyzed on a VITROS® Ektachem 950 IRC (Johnson & Johnson, Langhorne, PA, USA) using colorimetric assays.
Spec (analyzed) Gene_expression (analyzed) of HDL associated with disorder of lipid metabolism
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795198 Disease Relevance 0.35 Pain Relevance 0.07
Plasma levels of TG (p = 0.001), HDL-c (p = 0.002) and LDL-c (p = 0.02), but not total cholesterol, were higher in HFC mice than in SC mice.
Gene_expression (levels) of HDL in Plasma associated with disorder of lipid metabolism
7) Confidence 0.65 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 0.43 Pain Relevance 0
Many authors did not show any differences in apoA1, apoA2, and apoB levels between psoriatic patients and the control group [10, 76, 80].
Gene_expression (levels) of apoA2 associated with psoriasis
8) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.17 Pain Relevance 0.03
In this scenario of malfunction of G1-S checkpoint p53, c-Myc was a main factor accounting for ApoG2-induced S phase arrest.
Gene_expression (accounting) of ApoG2
9) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.90 Pain Relevance 0
In this case, downregulation of c-Myc expression by ApoG2 on one hand could let cells away from c-Myc-induced apoptosis and on other hand led to cell cycle arrest.
Gene_expression (expression) of ApoG2 associated with apoptosis
10) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.16 Pain Relevance 0.07
M ApoG2 induced about 60% HONE-1 cells arresting at S phase (Fig. 2D); in comparison, only 34% of untreated HONE-1 cells were arrested at S phase of the cell cycle.
Gene_expression (induced) of ApoG2
11) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.66 Pain Relevance 0
In in vivo experiments, for intraperitoneal (i.p.) injection, ApoG2 was suspended in 0.5% sodium carboxymethylcellulose and prepared on the day of use.


Gene_expression (prepared) of ApoG2
12) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.53 Pain Relevance 0
As expected, the mean levels of LDL-cholesterol, total triglycerides, Apo AI, Apo AII, Apo CIII, Apo E and Apo B were significantly different in the arterial disease group compared to controls.
Gene_expression (levels) of Apo AII associated with disease
13) Confidence 0.02 Published 2003 Journal BMC Med Genet Section Body Doc Link PMC201027 Disease Relevance 0.76 Pain Relevance 0
Furthermore, the Apo 2.7 antigen is expressed in apoptotic cells but not in normal cells or cells that undergo death by nonapoptotic mechanisms, such as necrosis.
Neg (not) Gene_expression (expressed) of Apo 2.7 in apoptotic cells associated with necrosis, apoptosis and death
14) Confidence 0.02 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC3004392 Disease Relevance 1.20 Pain Relevance 0.03
deposition was compared in mice expressing no ApoE, murine ApoE, or the various human ApoE isoforms (ApoE2, E3, and E4).
Gene_expression (ice expres) of ApoE2
15) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.83 Pain Relevance 0
by bone marrow-derived macrophages is dependent from APOE genotype with macrophages expressing apoE2 being more efficient at degrading A?
Gene_expression (expressing) of apoE2 in macrophages
16) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.35 Pain Relevance 0.22

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