INT174797

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Context Info
Confidence 0.03
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.05
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf4)
Tnfsf4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 195 99.24 Very High Very High Very High
metalloproteinase 5 86.32 High High
antagonist 5 82.20 Quite High
Inflammation 120 74.80 Quite High
tolerance 15 71.40 Quite High
chemokine 40 22.64 Low Low
Inflammatory stimuli 5 21.76 Low Low
Kinase C 5 12.20 Low Low
Angina 30 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 260 100.00 Very High Very High Very High
Atherosclerosis 140 100.00 Very High Very High Very High
Coronary Artery Disease 85 96.24 Very High Very High Very High
Disease 70 93.60 High High
Cancer 15 84.40 Quite High
Necrosis 10 83.92 Quite High
Cardiovascular Disease 30 79.84 Quite High
Cv Unclassified Under Development 15 76.28 Quite High
INFLAMMATION 160 74.80 Quite High
Graft Vs Host Disease 5 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2) conversely, can the interleukins effects on atherosclerosis be extrapolated to diabetes?
Regulation (effects) of atherosclerosis associated with diabetes mellitus and atherosclerosis
1) Confidence 0.03 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.86 Pain Relevance 0.04
Targeting of these cytokines – in an attempt to develop pharmacologic activators of the "good" interleukins, and inhibitors of the "bad" ones – might provide an effective means to simultaneously control both atherosclerosis and diabetes mellitus.


Regulation (control) of atherosclerosis associated with diabetes mellitus, atherosclerosis and cytokine
2) Confidence 0.03 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.02 Pain Relevance 0.13
Several essential questions remain yet unanswered: 1) does a favorable or harmful effect of a given IL on diabetes necessarily imply similar effects on atherosclerosis?
Regulation (effects) of atherosclerosis associated with atherosclerosis and diabetes mellitus
3) Confidence 0.03 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.90 Pain Relevance 0.03
Pharmacologic targeting of these cytokines might provide an effective means to simultaneously control both atherosclerosis and diabetes.



Regulation (control) of atherosclerosis associated with diabetes mellitus, atherosclerosis and cytokine
4) Confidence 0.02 Published 2003 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC212422 Disease Relevance 0.76 Pain Relevance 0.05
It may harmfully influence diabetes and atherosclerosis due to its capability to induce production of IL-6 and IL-8 [14].
Spec (may) Regulation (influence) of atherosclerosis associated with atherosclerosis and diabetes mellitus
5) Confidence 0.02 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.51 Pain Relevance 0.29

General Comments

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