INT174808

Context Info Confidence 0.01 First Reported 2003 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.35 Pain Relevance 0.31

nucleolus (COMMD1) nucleus (COMMD1) cytoplasm (COMMD1)

Anatomy Link Frequency cardiovascular system 1 COMMD1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 39 87.84 Inflammation 24 77.76 chemokine 8 51.84 beta blocker 1 40.52 Angina 6 5.00 antagonist 4 5.00 Inflammatory response 3 5.00 tolerance 3 5.00 Dismenorea 1 5.00 Dopamine 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 36 100.00 Stress 31 97.48 Myocardial Infarction 4 93.28 INFLAMMATION 32 87.44 Coronary Heart Disease 3 86.24 Diabetes Mellitus 52 77.08 Asthma 2 67.20 Breast Cancer 11 50.00 Lymphatic System Cancer 1 24.96 Insulin Resistance 2 15.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Regulation of 13 genes representing the 6 functional categories, apoptosis, proliferation, general growth, signaling & transport, metabolism and others, were verified by real-time RT-PCR from independent samples to confirm the regulation of genes connected to the major cellular effects observed.

Regulation (Regulation) of metabolism associated with apoptosis

1) Confidence 0.01 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.57 Pain Relevance 0

Substantial effects on glucose metabolism and cardiovascular system have not been described for these compounds.

Regulation (effects) of metabolism in cardiovascular system

2) Confidence 0.00 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.78 Pain Relevance 0.31

General Comments

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