INT174820

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Context Info
Confidence 0.20
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.32
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, VEGFA) extracellular region (IL6, VEGFA) growth (VEGFA)
aging (IL6) proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cells 2
IL6 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 62.24 Quite High
Pain 18 5.00 Very Low Very Low Very Low
vincristine 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 112 99.38 Very High Very High Very High
Infection 20 91.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 54 89.68 High High
Lymphadenopathy 18 83.72 Quite High
Kaposis Sarcoma 18 54.44 Quite High
Lymphatic System Cancer 16 42.72 Quite Low
Lymphoproliferative Disease 2 41.28 Quite Low
Hot Flashes 12 19.20 Low Low
Fatigue 2 6.12 Low Low
Weight Loss 6 5.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One hypothesis for the origin of MCD is that HHV-8 expresses viral IL-6, which induces vascular endothelial growth factor (VEGF), which then induces human IL-6 production by endothelial cells. [19] Use of neutralizing antibodies against IL-6 and monoclonal antibody blocking the IL-6 receptor, have demonstrated clinical efficacy, resulting in symptom resolution. [20,21] All seven patients, in one study, treated with monoclonal antibodies to IL-6 receptor had resolution of their clinical symptoms, followed by improvement in their lymphadenopathy. [22] Once therapy was stopped, however, symptoms recurred.
IL-6 Positive_regulation (induces) of vascular endothelial growth factor in endothelial cells associated with lymphadenopathy and disease
1) Confidence 0.20 Published 2003 Journal BMC Infect Dis Section Body Doc Link PMC212557 Disease Relevance 1.63 Pain Relevance 0.06
One hypothesis for the origin of MCD is that HHV-8 expresses viral IL-6, which induces vascular endothelial growth factor (VEGF), which then induces human IL-6 production by endothelial cells. [19] Use of neutralizing antibodies against IL-6 and monoclonal antibody blocking the IL-6 receptor, have demonstrated clinical efficacy, resulting in symptom resolution. [20,21] All seven patients, in one study, treated with monoclonal antibodies to IL-6 receptor had resolution of their clinical symptoms, followed by improvement in their lymphadenopathy. [22] Once therapy was stopped, however, symptoms recurred.
IL-6 Positive_regulation (induces) of VEGF in endothelial cells associated with lymphadenopathy and disease
2) Confidence 0.20 Published 2003 Journal BMC Infect Dis Section Body Doc Link PMC212557 Disease Relevance 1.68 Pain Relevance 0.06

General Comments

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