INT174838

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 80
Total Number 84
Disease Relevance 19.05
Pain Relevance 12.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
pituitary 5
neutrophils 3
brain 2
mouth 2
urothelial cells 2
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1198 100.00 Very High Very High Very High
cytokine 624 100.00 Very High Very High Very High
Opioid 214 100.00 Very High Very High Very High
Inflammatory response 69 99.98 Very High Very High Very High
aspirin 238 99.92 Very High Very High Very High
analgesia 68 99.74 Very High Very High Very High
tolerance 23 99.70 Very High Very High Very High
IPN 57 99.40 Very High Very High Very High
agonist 368 99.28 Very High Very High Very High
substance P 240 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1258 100.00 Very High Very High Very High
Cancer 616 100.00 Very High Very High Very High
Solid Tumor 6 100.00 Very High Very High Very High
Inflammatory Pain 57 99.40 Very High Very High Very High
Severe Combined Immunodeficiency 12 98.84 Very High Very High Very High
Asthma 320 97.96 Very High Very High Very High
Uveitis 25 97.68 Very High Very High Very High
Inflammatory Bowel Disease 113 97.60 Very High Very High Very High
Disease Progression 45 97.28 Very High Very High Very High
Edema 2 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tablets prepared were evaluated for thickness, uniformity of weight, content uniformity, hardness, friability, wetting time, in vitro and in vivo disintegration time, mouth feel, in vitro drug release and assay by high performance liquid chromatography.
Localization (release) of in vitro in mouth
1) Confidence 0.64 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Abstract Doc Link PMC2883231 Disease Relevance 0 Pain Relevance 0
The tablets prepared were evaluated for thickness, uniformity of weight, content uniformity, hardness, friability, wetting time, in vitro and in vivo disintegration time, mouth feel, in vitro drug release and assay by high performance liquid chromatography.
Localization (release) of in vitro in mouth
2) Confidence 0.64 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Abstract Doc Link PMC2883231 Disease Relevance 0 Pain Relevance 0
In vitro release rate studies:
Localization (release) of In vitro
3) Confidence 0.60 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883231 Disease Relevance 0 Pain Relevance 0
In vitro release of betahistine from grafted SWCNT–betahistine
Localization (release) of In vitro
4) Confidence 0.13 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939709 Disease Relevance 0 Pain Relevance 0
In vitro release of dipyridamol from grafted SWCNT–dipyridamol
Localization (release) of In vitro
5) Confidence 0.13 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939709 Disease Relevance 0 Pain Relevance 0
Seed disinfection, germination, and in vitro multiplication
Localization (multiplication) of in vitro
6) Confidence 0.13 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2881646 Disease Relevance 0.54 Pain Relevance 0
In vitro release of betahistine and dipyridamol from their corresponding grafted SWCNT adducts was studied, which indicates that drug release can occur smoothly from covalent SWCNT–drug adducts during long time intervals, and this can be considered a useful method for drug delivery.



Localization (release) of In vitro
7) Confidence 0.12 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939709 Disease Relevance 0 Pain Relevance 0
We have developed an automated selection protocol that is designed to be as close as possible to manual in vitro selection.
Localization (selection) of in vitro
8) Confidence 0.11 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.10
As these CB cells selectively home into the lesioned brain areas [45,46,52,53,58], the release of neurotrophic and angiogenic factors [64,65] and/or antioxidants in vivo, as shown in vitro, would be highly specific and locally limited to the damaged brain area, supporting a ”bystander” neuroprotective strategy [66].
Localization (release) of in vivo in brain
9) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0.38 Pain Relevance 0.12
Result revealed that the In-vitro drug release of aspirin at pH-1.2 for first two hours was very slow followed by instant release at pH-6.0.
Localization (release) of In-vitro associated with aspirin
10) Confidence 0.08 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.17
In-vitro drug release studies
Localization (release) of In-vitro
11) Confidence 0.08 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.09
Moreover, in-vitro release of aspirin from CAP microcapsules was best explained by Korsmeyer-Peppas equation indicated a good linearity (r2=0.978).
Localization (release) of in-vitro associated with aspirin
12) Confidence 0.08 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.19
In-vitro drug release
Localization (release) of In-vitro
13) Confidence 0.08 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.14
Importance of Exposure Time In Vitro
Localization (Importance) of In Vitro
14) Confidence 0.07 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.53 Pain Relevance 0
As these CB cells selectively home into the lesioned brain areas [45,46,52,53,58], the release of neurotrophic and angiogenic factors [64,65] and/or antioxidants in vivo, as shown in vitro, would be highly specific and locally limited to the damaged brain area, supporting a ”bystander” neuroprotective strategy [66].
Localization (release) of in vitro in brain
15) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0.39 Pain Relevance 0.12
However, the in-vitro release characteristics of drug from the microcapsules are subject to confirmation in animal and human studies for concluding enhanced bioavailability and reduced dose frequency for improved patient compliance.


Localization (release) of in-vitro associated with bioavailability
16) Confidence 0.07 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.18
Characterization of the formulations was performed by size, shape, drug loading efficiency and in-vitro drug release analysis.
Localization (release) of in-vitro
17) Confidence 0.07 Published 2010 Journal Scientia Pharmaceutica Section Abstract Doc Link PMC3002828 Disease Relevance 0 Pain Relevance 0.08
The prepared microcapsules were evaluated for drug content, particle-size, SEM and for in-vitro drug release study.


Localization (release) of in-vitro
18) Confidence 0.07 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002828 Disease Relevance 0.11 Pain Relevance 0.21
Morphine has been shown to cause significant histamine release in vivo, but it has not been investigated whether sulfite, in the form of the sulfite radical, is the cause of this release.
Localization (release) of in vivo associated with morphine
19) Confidence 0.05 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 0.40
HCA was classified as a contact sensitizer serving as a positive control in the LLNA and tested in other in vitro sensitizations tests [15], [38].
Localization (sensitizations) of in vitro
20) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.05 Pain Relevance 0

General Comments

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