INT174839

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.91
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BSG) small molecule metabolic process (BSG) plasma membrane (BSG)
Anatomy Link Frequency
macrophages 1
monocytes 1
stromal cells 1
BSG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 84 99.12 Very High Very High Very High
Arthritis 41 97.44 Very High Very High Very High
cytokine 31 96.28 Very High Very High Very High
Inflammatory response 8 92.24 High High
Inflammatory stimuli 2 57.44 Quite High
Osteoarthritis 19 51.08 Quite High
metalloproteinase 60 50.00 Quite Low
antagonist 31 50.00 Quite Low
rheumatoid arthritis 20 33.44 Quite Low
Multiple sclerosis 2 26.16 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 29 100.00 Very High Very High Very High
Disease 44 99.96 Very High Very High Very High
INFLAMMATION 89 99.12 Very High Very High Very High
Arthritis 46 97.44 Very High Very High Very High
Inflammatory Bowel Disease 22 95.52 Very High Very High Very High
Genomic Instability 2 88.40 High High
Arthropathy 1 82.12 Quite High
Malignant Neoplastic Disease 1 79.88 Quite High
Apoptosis 1 78.24 Quite High
Cellulitis 1 65.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By using the streptococcal M6 protein as the fusion partner [31], an S. gordonii strain secreting human IL-1ra into the culture medium was constructed and denominated GP1300.
Localization (secreting) of M6 associated with sprains and strains
1) Confidence 0.68 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.45 Pain Relevance 0.03
The RTKs are present at the cell surface and are the initial members of signaling cascades that respond to extracellular ligands secreted by other cells or by the same cell (autocrine action).
Localization (secreted) of extracellular
2) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727778 Disease Relevance 0.30 Pain Relevance 0
is produced predominantly by activated monocytes and macrophages (3); however, mechanisms of cellular release into the extracellular environment remain the subject of much investigation.
Localization (release) of extracellular in macrophages
3) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.58 Pain Relevance 0.24
Extracellular proteases are secreted in SF by infiltrating inflammatory cells and/or by stromal cells stimulated by inflammatory cytokines [21,22].
Localization (secreted) of Extracellular in stromal cells associated with inflammation and cytokine
4) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 1.01 Pain Relevance 0.47
is produced predominantly by activated monocytes and macrophages (3); however, mechanisms of cellular release into the extracellular environment remain the subject of much investigation.
Localization (release) of extracellular in monocytes
5) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.58 Pain Relevance 0.24

General Comments

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