INT174844

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 81
Total Number 83
Disease Relevance 18.03
Pain Relevance 12.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
neurons 5
striatum 2
bands 2
lever 2
hepatocytes 2
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 214 100.00 Very High Very High Very High
Pyramidal cell 210 100.00 Very High Very High Very High
Hyperalgesia 179 100.00 Very High Very High Very High
tetrodotoxin 178 100.00 Very High Very High Very High
Nucleus accumbens 163 100.00 Very High Very High Very High
allodynia 68 100.00 Very High Very High Very High
gABA 219 99.96 Very High Very High Very High
cytokine 48 99.80 Very High Very High Very High
Morphine 39 99.44 Very High Very High Very High
Duloxetine 33 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 218 100.00 Very High Very High Very High
Neuropathic Pain 167 100.00 Very High Very High Very High
Anxiety Disorder 97 100.00 Very High Very High Very High
Immunization 19 100.00 Very High Very High Very High
Stress 187 99.88 Very High Very High Very High
Ocular Hypertension 15 99.74 Very High Very High Very High
Adhesions 32 99.42 Very High Very High Very High
Injury 317 99.12 Very High Very High Very High
Aging 57 99.12 Very High Very High Very High
Cancer 118 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sessions 2–5, when vehicle was replaced with amphetamine, the contingent group gradually increased responding on both levers over the sessions, but the noncontingent group did not (Fig. 7; a significant interaction between effects of group and session, F4,11?
Fig Binding (interaction) of in levers
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806927 Disease Relevance 0 Pain Relevance 0.03
Delayed presentation of visual signals decreased active lever pressing facilitated by amphetamine, but did not reliably influence inactive lever presses (Fig. 3A; a significant delay x lever interaction, F2,11?
Fig Binding (interaction) of in lever
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806927 Disease Relevance 0 Pain Relevance 0.09
These equations exhibit periodic recruitment, Fig. 10, with a period that is dependent upon the flux of lipid needing storage.
Fig Binding (recruitment) of
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809739 Disease Relevance 0.51 Pain Relevance 0
M lindane (Fig. 2).
Fig Binding (lindane) of
4) Confidence 0.25 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC222921 Disease Relevance 0 Pain Relevance 0
All the isoboles of the 4 models are upward concave and consistently indicate synergistic interaction (Fig. 2).
Fig Binding (interaction) of
5) Confidence 0.24 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2881515 Disease Relevance 0 Pain Relevance 0.04
Tiagabine also had noticeable effects on sEPSCs, and the data are summarized in Fig. 4D.
Fig Binding (summarized) of
6) Confidence 0.23 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.07
Compared to naive rats, adhesive bands of collagen fibers formed at the level of ligation (Fig. 1b).
Fig Binding (ligation) of in bands
7) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.58 Pain Relevance 0.18
Other pathways that were predominantly down regulated were cancer, focal adhesion, cytokine-cytokine receptor interaction, wnt signaling, tight junction, MAPK signaling, and retinol metabolism pathways (Fig. 3).Fig. 3KEGG functional pathways affected 3 h post bolus when rats fed betaine and ethanol were compared with rats fed ethanol alone (n = 3, the total number of genes in each pathway is listed on the x axis)
Fig Binding (interaction) of associated with cancer, adhesions and cytokine
8) Confidence 0.19 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.40 Pain Relevance 0.20
Four models, except for the Berenbaum method, consistently show interaction indices of less than 1, which mean synergistic interaction (Table 1 and Fig. 3).
Fig Binding (interaction) of
9) Confidence 0.19 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2881515 Disease Relevance 0 Pain Relevance 0.03
Therefore, the response surface models with a single interaction parameter are inadequate to analyze the data which has complicated scatter of different types of drug interactions (Fig. 3 and 4, Panel A).
Fig Binding (interactions) of
10) Confidence 0.19 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2881515 Disease Relevance 0 Pain Relevance 0
4.474 for the stress- DMI interaction, p<0.05), which was totally ineffective in non-stressed rats (Fig. 5B,C).
Fig Binding (interaction) of associated with stress
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.50 Pain Relevance 0.33
The influence of femoral artery ligation on the amount of microspheres trapped in the femur in Fig. 5A revealed that the bead amount increases at the third week after ligation.
Fig Binding (ligation) of in femur
12) Confidence 0.18 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810364 Disease Relevance 0 Pain Relevance 0.04
The effects of morphine and duloxetine were evaluated in rats at 8 weeks after ligation of the TASM when persistent mechanical hyperalgesia/allodynia had developed (Fig. 2a).
Fig Binding (ligation) of associated with hyperalgesia, allodynia, duloxetine and morphine
13) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.49 Pain Relevance 1.28
m GABA (Fig. 3) confirms that BDZs strongly up regulate the agonist binding.
Fig Binding (binding) of associated with gaba and agonist
14) Confidence 0.17 Published 2007 Journal The Journal of Physiology Section Body Doc Link PMC2375456 Disease Relevance 0 Pain Relevance 0.43
As in the adults, the mEPSC frequency was also increased in the juvenile rats after TTX treatment (inter-event intervals: Control: 4.11±0.41 sec, TTX: 1.9±0.22 sec; Fig 3B; control: n?
Fig Binding (inter) of in juvenile associated with tetrodotoxin
15) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933594 Disease Relevance 0 Pain Relevance 0.99
Surprisingly, the mIPSCs recorded from adult rats after TTX treatment showed a significant increase in amplitude (Control: 28.9±0.72 pA, TTX: 43.43±1.05 pA; Fig 4A; control: n?
Fig Binding (1.05) of associated with tetrodotoxin
16) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933594 Disease Relevance 0 Pain Relevance 1.02
In the laminated subnucleus caudalis and upper cervical dorsal horn, Fos-positive cells were mainly clustered in the medial-intermediate portion of superficial laminae on the side ipsilateral to ligation (Fig. 4a).
Fig Binding (ligation) of in dorsal horn associated with dorsal horn
17) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.48 Pain Relevance 0.41
6, p<0.0001; Fig. 1C) associated with a 42% decrease in the nucleus accumbens (0.230±0.0153 for control animals, AU, n?
Fig Binding (p<0.0001) of in nucleus accumbens associated with nucleus accumbens
18) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.55
6, p<0.001; Fig. 1B) and 227% in the nucleus accumbens (0.081±0.0264 control animal, n?
Fig Binding (p<0.001) of in nucleus accumbens associated with nucleus accumbens
19) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.63
Paw-withdrawal duration to cold, as measured by the acetone drop test increased at day 7, peaked at day 12, and was maintained for 24 days following ligation (Fig. 2). 3-way ANOVA for paw-withdrawal duration as a function of animal grouping, day of test, and paw tested was highly significant for all 3 factors (for animal grouping F2,199 = 997.; for test day F3,199 = 137.; and for paw tested F1,199 = 1142.; p < 10-5 for all 3 factors), for their pair-wise interactions (p < 10-5) and for their 3 way interaction (p < 10-5).


Fig Binding (ligation) of in paw associated with withdrawal
20) Confidence 0.17 Published 2005 Journal Mol Pain Section Body Doc Link PMC1156939 Disease Relevance 0.91 Pain Relevance 0.15

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