INT174848

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.79
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ISCU) mitochondrion (ISCU) nucleus (ISCU)
cytoplasm (ISCU)
Anatomy Link Frequency
tendon 1
ISCU (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 5 99.92 Very High Very High Very High
Pain 11 47.76 Quite Low
Inflammation 3 36.64 Quite Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscle Disease 45 99.92 Very High Very High Very High
Sideroblastic Anemia 75 99.24 Very High Very High Very High
Ataxia 120 98.80 Very High Very High Very High
Disease 135 96.12 Very High Very High Very High
Iron Overload 120 94.80 High High
Anaemia 90 94.60 High High
Cicatrix 2 84.40 Quite High
Friedreich Ataxia 10 83.16 Quite High
Genomic Instability 10 66.28 Quite High
Fatigue 9 64.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Isu1, its homologue Isu2, Nfu, Isa1, and Isa2 are all proposed to function as scaffold proteins upon which Fe?
Gene_expression (proposed) of Isu2
1) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0 Pain Relevance 0
Pathology is manifested as sensory problems in Friedreich's ataxia, sideroblastic anemia in GLRX5 deficiency, and myopathy in ISCU deficiency, but it is unlikely that the fundamental defect is limited to these specific tissues, at least for some gene mutations.
Gene_expression (deficiency) of ISCU associated with sideroblastic anemia, ataxia and muscle disease
2) Confidence 0.52 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.12 Pain Relevance 0
ISCU proteins in these patients are expressed at a normal level, but they are nonfunctional.
Gene_expression (expressed) of ISCU
3) Confidence 0.52 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.63 Pain Relevance 0.05
S proteins, including ISCU (29), frataxin (53), and ISD11 (26), defective mitochondrial Fe?
Gene_expression (defective) of ISCU
4) Confidence 0.52 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.72 Pain Relevance 0
The ISCU depletion leads to defective Fe?
Gene_expression (depletion) of ISCU
5) Confidence 0.52 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.23 Pain Relevance 0.03
Note that it is possible to machine specifically adapted screws that allow fixation of the PVDF tendon under different angles between the axis of the screw and the tendon.
Gene_expression (allow) of fixation in tendon
6) Confidence 0.04 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.08 Pain Relevance 0

General Comments

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