INT174851

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 12.73
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
cartilage 5
tendon 3
chondrocytes 1
uterine smooth muscle 1
liver 1
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 378 100.00 Very High Very High Very High
Arthritis 51 100.00 Very High Very High Very High
Osteoarthritis 395 99.84 Very High Very High Very High
dexamethasone 860 98.70 Very High Very High Very High
cytokine 153 95.92 Very High Very High Very High
fibrosis 45 91.92 High High
metalloproteinase 83 89.76 High High
ischemia 10 70.12 Quite High
corticosteroid 14 63.76 Quite High
Neuropeptide 7 63.72 Quite High
Disease Link Frequency Relevance Heat
Arthritis 61 100.00 Very High Very High Very High
Experimental Arthritis 6 100.00 Very High Very High Very High
Keloid Scars 220 99.88 Very High Very High Very High
Breast Cancer 62 99.88 Very High Very High Very High
Frailty 255 99.84 Very High Very High Very High
Osteoarthritis 157 99.84 Very High Very High Very High
Primary Sclerosing Cholangitis 31 99.84 Very High Very High Very High
Myeloid Leukemia 4 99.72 Very High Very High Very High
Injury 199 99.52 Very High Very High Very High
Airway Remodeling 2 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the same report the authors also described an increase in type V collagen in neovascularization and tissue remodeling, similar as occurred in our study in PTTD, where the type V collagen was found distributed all over the tendon, but mainly in the perivascular region.
Positive_regulation (increase) of collagen in tendon associated with posterior tibial tendon dysfunction
1) Confidence 0.54 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.47 Pain Relevance 0
Type V collagen is augmented in the tendon interstitium but is specifically distributed close to newly formed vessels.
Positive_regulation (augmented) of collagen in tendon
2) Confidence 0.54 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.24 Pain Relevance 0.05
The role of collagen in the tendon has been studied extensively, and rotator cuff injury is one of the best examples of a tendon rupture syndrome related to abnormal collagen synthesis.13,14 It was admitted that tendon degeneration could be caused by repetitive microinjuries, which are subsequently repaired by removal of damaged matrix and deposition of newly abnormal synthesized collagen liable to rupture.13,14
Positive_regulation (role) of collagen in tendon associated with syndrome, rupture and rotator cuff tears
3) Confidence 0.45 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.95 Pain Relevance 0.06
More specifically in posterior tibial tendon dysfunction, Gonçalves et al.6 showed through biochemical study an increase of 53.6% in type III collagen and 26.4% of type V collagen and a decrease of 40.4% in the alfa-1 chain and 42.5% in the alfa-2 chain of type I collagen without modification of the total collagen amount.
Positive_regulation (increase) of collagen in posterior associated with posterior tibial tendon dysfunction
4) Confidence 0.36 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.64 Pain Relevance 0
Type III collagen levels were also increased in pathological specimens.
Positive_regulation (increased) of collagen
5) Confidence 0.36 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664193 Disease Relevance 0.48 Pain Relevance 0
In the next step, the stabilized collagen network is infiltrated by a hydrophobic monomer that fills the interfibrillar spaces in the collagen network.
Positive_regulation (stabilized) of collagen
6) Confidence 0.34 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.09 Pain Relevance 0
Therefore, it can be concluded that thrombin-induced uterine smooth muscle cell collagen contractility is mediated by F2R activation and may in part be ROCK-1 dependent.
Positive_regulation (mediated) of collagen in uterine smooth muscle
7) Confidence 0.19 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
-induced contraction, resulting in an increase in collagen area of 28% (P < 0.001), at 2 hours 30 minutes.
Positive_regulation (increase) of collagen
8) Confidence 0.19 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
(10 ng/ml) increased collagen contractility, with a decrease in gel area of 9.5% (P < 0.05) to a peak of 47.3% (P < 0.001), 6 to 26 hrs respectively, after treatment, in comparison to un-stimulated collagen embedded hUtSMCs (Figure 2A).
Positive_regulation (increased) of collagen
9) Confidence 0.17 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Effect of thrombin treatment on hUtSMC collagen contractility
Positive_regulation (hUtSMC) of collagen
10) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
It is assumed that the cross-linked peptide originating from the triple helical domain is contributed from a different molecule of collagen from that of the telopeptides (which can hypothetically originate from two ?
Positive_regulation (molecule) of collagen
11) Confidence 0.16 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.17 Pain Relevance 0.03
Levels of this neoepitope were high a few weeks after an experimentally induced inflammatory arthritis (collagen induced arthritis, CIA) or OA (Song et al. 1999; Kojima et al. 2001; Chu et al. 2002; Kojima, 2004; Billinghurst et al. 2001).
Positive_regulation (induced) of collagen associated with inflammation, experimental arthritis, osteoarthritis and arthritis
12) Confidence 0.16 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.53 Pain Relevance 0.24
In a cartilage explant system, cleavage of type II collagen by collagenase was significantly increased in OA cartilage samples, generating higher levels of C1,2C in vitro from OA cartilage; this elevation could be blocked by collagenase inhibitors (Dahlberg et al. 2000).
Positive_regulation (increased) of collagen in cartilage associated with osteoarthritis
13) Confidence 0.14 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.43 Pain Relevance 0.18
In the liver, a marked enlargement of centrilobular sinusoids was observed, and an increase of collagen staining surrounding sinusoids was also notorious (Fig. 3D).
Positive_regulation (increase) of collagen in liver
14) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745573 Disease Relevance 0.69 Pain Relevance 0.03
In the ACL cultures, once again at week one the pattern of collagen accumulation paralleled changes in cell number indicating that the rate of collagen accumulation per cell number was constant over the range of dexamethasone doses.
Positive_regulation (accumulation) of collagen associated with dexamethasone
15) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.31
Collagen accumulation
Positive_regulation (accumulation) of Collagen
16) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.12
However, after 2 weeks in culture the pattern changed in that the control cultures showed a proportionally greater increase in collagen accumulation than the PT cultures.
Positive_regulation (accumulation) of collagen
17) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.23
However the rate of increase between the first and second week of culture was far greater for collagen accumulation than for cell number with a 100% increase in the amount of collagen compared with about 25% increase in cell number in the control cultures suggesting a process of differentiation and specific increase in collagen accumulation (Fig. 3A).
Positive_regulation (increase) of collagen
18) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.32
However the rate of increase between the first and second week of culture was far greater for collagen accumulation than for cell number with a 100% increase in the amount of collagen compared with about 25% increase in cell number in the control cultures suggesting a process of differentiation and specific increase in collagen accumulation (Fig. 3A).
Positive_regulation (accumulation) of collagen
19) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.33
However the rate of increase between the first and second week of culture was far greater for collagen accumulation than for cell number with a 100% increase in the amount of collagen compared with about 25% increase in cell number in the control cultures suggesting a process of differentiation and specific increase in collagen accumulation (Fig. 3A).
Positive_regulation (accumulation) of collagen
20) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.29

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