INT174864

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.58
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
hippocampus 6
monocytes 2
striatum 2
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 92 99.30 Very High Very High Very High
Hippocampus 12 98.32 Very High Very High Very High
fluoxetine 8 96.48 Very High Very High Very High
antidepressant 16 96.26 Very High Very High Very High
sSRI 12 95.96 Very High Very High Very High
Angina 93 87.16 High High
Nicotine 4 83.88 Quite High
Crohn's disease 5 54.16 Quite High
Serotonin 4 38.96 Quite Low
imagery 8 26.28 Quite Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 219 99.82 Very High Very High Very High
Depression 112 99.30 Very High Very High Very High
Eosinophilic Esophagitis 106 99.20 Very High Very High Very High
Diabetes Mellitus 96 99.06 Very High Very High Very High
Hypoxia 12 96.24 Very High Very High Very High
Hyperlipidemia 21 93.96 High High
Hypertension 18 92.88 High High
Nicotine Addiction 15 92.32 High High
Heart Disease 6 91.56 High High
Schizophrenia 8 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Positive_regulation (led) of Transcription (levels) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
1) Confidence 0.44 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.92 Pain Relevance 0.62
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Positive_regulation (increased) of Transcription (levels) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
2) Confidence 0.44 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.92 Pain Relevance 0.62
We observed no significant deviation from the untreated mRNA levels for VEGF and bFGF during a 48 hour period after treatment with glucose alone or in combination with fluvastatin.
Neg (no) Positive_regulation (deviation) of Transcription (levels) of bFGF
3) Confidence 0.43 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.38 Pain Relevance 0.16
Quantitation of the mRNA for VEGF, bFGF and TGF-?
Positive_regulation (for) of Transcription (Quantitation) of bFGF
4) Confidence 0.43 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.40 Pain Relevance 0.22
Peripheral monocytes from diabetic patients with coronary artery disease display increased bFGF and VEGF mRNA expression

Background

Positive_regulation (increased) of Transcription (expression) of bFGF in monocytes associated with coronary artery disease and diabetes mellitus
5) Confidence 0.40 Published 2003 Journal J Transl Med Section Title Doc Link PMC239962 Disease Relevance 1.02 Pain Relevance 0.12
Transcripts for bFGF were found to be increased in newly diagnosed EoE subjects and expression was decreased after treatment.
Positive_regulation (increased) of Transcription (Transcripts) of bFGF associated with eosinophilic esophagitis
6) Confidence 0.27 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.09 Pain Relevance 0.03
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Positive_regulation (led) of in striatum Transcription (levels) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
7) Confidence 0.15 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.92 Pain Relevance 0.62
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Positive_regulation (increased) of in striatum Transcription (levels) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
8) Confidence 0.15 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.92 Pain Relevance 0.62

General Comments

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