INT174866

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 7.13
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
FaDu 3
fibroblast 2
HeLa 1
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 93 98.32 Very High Very High Very High
COX-2 inhibitor 12 84.24 Quite High
cytokine 9 80.12 Quite High
antagonist 2 67.96 Quite High
agonist 2 66.16 Quite High
Inflammation 19 62.04 Quite High
corticosteroid 5 50.84 Quite High
ischemia 13 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 24 100.00 Very High Very High Very High
Cv General 3 Under Development 81 98.32 Very High Very High Very High
Coronary Artery Disease 219 98.24 Very High Very High Very High
Cancer 127 97.84 Very High Very High Very High
Pulmonary Disease 52 97.30 Very High Very High Very High
Hyperlipidemia 21 94.96 High High
Hypertension 18 93.88 High High
Nicotine Addiction 22 93.32 High High
Diabetes Mellitus 96 92.96 High High
Heart Disease 6 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of glucose and statins in the expression of VEGF and bFGF
Regulation (statins) of Gene_expression (expression) of bFGF
1) Confidence 0.39 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.12 Pain Relevance 0.17
A representative semi-quantitative RT-PCR assay demonstrating a range of differences in the production of VEGF, bFGF and TGF-?
Regulation (differences) of Gene_expression (production) of bFGF
2) Confidence 0.39 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.54 Pain Relevance 0.27
In order to investigate further the relation of the mRNA expression of VEGF, bFGF and TGF-?
Spec (investigate) Regulation (relation) of Gene_expression (expression) of bFGF
3) Confidence 0.39 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 2.34 Pain Relevance 0.52
Effect of fibroblast growth factor-2 expansion on subsequent chondrogenic differentiation
Regulation (Effect) of Gene_expression (expansion) of fibroblast growth factor-2 in fibroblast
4) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.28 Pain Relevance 0
Recently, in a cross-sectional study on COPD patients, we found that, as compared to untreated patients, treated patients with long-term high doses of beclomethasone showed lower values of vascular area and lower expression of VEGF, bFGF, and TGF?
Regulation (values) of Gene_expression (expression) of bFGF associated with pulmonary disease
5) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 0.63 Pain Relevance 0.16
Hence, we first analysed the effect of WX-UK1, Galardin®, and Celecoxib® on the ability of FaDu and HeLa carcinoma cells to produce neo-angiogenic factors such as bFGF.
Spec (analysed) Regulation (effect) of Gene_expression (produce) of bFGF in FaDu associated with carcinoma
6) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 0.61 Pain Relevance 0.04
Hence, we first analysed the effect of WX-UK1, Galardin®, and Celecoxib® on the ability of FaDu and HeLa carcinoma cells to produce neo-angiogenic factors such as bFGF.
Spec (analysed) Regulation (effect) of in HeLa Gene_expression (produce) of bFGF in FaDu associated with carcinoma
7) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 0.61 Pain Relevance 0.04

General Comments

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