INT174873

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.71
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
muscle 2
oviduct 2
inner ear 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 55 99.36 Very High Very High Very High
chemokine 1 90.80 High High
metalloproteinase 1 73.60 Quite High
Angina 31 54.88 Quite High
pain pelvic 2 51.92 Quite High
psoriasis 1 44.52 Quite Low
cva 12 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 20 100.00 Very High Very High Very High
Ectopic Pregnancy 95 99.96 Very High Very High Very High
Renal Cancer 65 99.84 Very High Very High Very High
Diabetes Mellitus 87 99.50 Very High Very High Very High
Hypoxia 22 99.10 Very High Very High Very High
Solid Tumor 7 87.80 High High
Ganglion Cysts 19 87.60 High High
Cancer 81 84.20 Quite High
Coronary Heart Disease 1 82.40 Quite High
Atherosclerosis 21 76.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore we analyzed in the above model the effect of high glucose levels found in diabetic individuals and statins found in the medication of all our patients on the mRNA levels of VEGF and bFGF during a 48 hour period.
Regulation (found) of Transcription (levels) of VEGF associated with diabetes mellitus
1) Confidence 0.43 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.72 Pain Relevance 0.11
One such example involves hypoxia-inducible factor-1, a transcription factor that regulates the expression of many angiogenesis- and glucose metabolism-related genes and in addition activates the transcription of VEGF in malignant gliomas.38,39 VEGF mRNA expression, as well as VEGF receptor expression, are well documented hypoxic induced changes in malignant gliomas.40
Regulation (malignant) of Transcription (expression) of VEGF associated with hypoxia and glioma
2) Confidence 0.40 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895775 Disease Relevance 1.06 Pain Relevance 0.08
Inappropriate activation of the hypoxia response pathway, is the major mechanism of VEGF transcriptional regulation in renal cell carcinoma.2 The HIF?
Regulation (regulation) of Transcription (transcriptional) of VEGF associated with hypoxia and renal cancer
3) Confidence 0.33 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.55 Pain Relevance 0
In an attempt to characterize factors affecting production and secretion of VEGF in EP, expression of VEGF mRNA and the VEGF receptors KDR and flt-1 were measured in implanted and non-implanted sites of the oviduct in women with EP41.
Regulation (measured) of Transcription (expression) of VEGF in oviduct associated with ectopic pregnancy
4) Confidence 0.26 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.90 Pain Relevance 0.05
Transcript levels of VEGF could be restored at the low alendronate concentration with the addition of GGOH indicating that transcription was regulated by intracellular signaling pathways utilizing geranylgeranylated proteins.
Regulation (regulated) of Transcription (transcription) of VEGF
5) Confidence 0.24 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0 Pain Relevance 0
VEGF isoform mRNA expression depends on transcription, splicing, and degradation of mRNA, and protein expression additionally depends upon translational rate and degradation rate.
Regulation (depends) of Transcription (expression) of VEGF
6) Confidence 0.16 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.05
To examine the changes in the expression of VEGF proteins and VEGF mRNAs in the inner ear caused by EP2 and EP4 agonists, we performed ELISA and real-time qRT-PCR analyses of extracts from inner ear specimens following the local application of EP2 and EP4 agonists or control substrates.
Spec (examine) Regulation (changes) of Spec (examine) Transcription (expression) of VEGF in inner ear associated with agonist
7) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.15 Pain Relevance 0.26
Diabetes and TA treatment differentially regulated the transcription of Vegf-a and its receptors.
Regulation (regulated) of Transcription (transcription) of Vegf associated with diabetes mellitus
8) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.26 Pain Relevance 0
and Vegf mRNA expression in TA muscle was significantly attenuated in p38?
Regulation (muscle) of Transcription (expression) of Vegf in muscle
9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.07 Pain Relevance 0

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