INT17489

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 28
Total Number 29
Disease Relevance 15.79
Pain Relevance 4.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
platelets 3
Bar 1
plasma 1
cerebrospinal fluid 1
spinal 1
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 39 100.00 Very High Very High Very High
Pain 30 100.00 Very High Very High Very High
cva 10 98.62 Very High Very High Very High
rheumatoid arthritis 38 97.70 Very High Very High Very High
Angina 12 97.56 Very High Very High Very High
Arachnoiditis 2 97.50 Very High Very High Very High
Perioperative pain 3 97.44 Very High Very High Very High
backache 4 94.20 High High
ischemia 7 93.64 High High
Analgesic 1 87.88 High High
Disease Link Frequency Relevance Heat
Adhesions 30 100.00 Very High Very High Very High
Pain 28 100.00 Very High Very High Very High
Fibrosis 2 100.00 Very High Very High Very High
Hemorrhage 39 99.76 Very High Very High Very High
Ocular Injury 2 99.56 Very High Very High Very High
Seroma 20 99.40 Very High Very High Very High
Renal Disease 3 99.20 Very High Very High Very High
Thrombosis 12 99.16 Very High Very High Very High
Coagulation Disorder 13 99.02 Very High Very High Very High
Recurrence 4 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors urge the readers to keep in mind the possibility of subclinical spinal arachnoiditis in the patients with aneurysmal subarachnoid hemorrhage and suggest that care should be taken to avoid any possible adverse effect of fibrin glue.
Spec (possible) Regulation (effect) of fibrin in spinal associated with arachnoiditis, subarachnoid hemorrhage and cva
1) Confidence 0.45 Published 1996 Journal J. Neurosurg. Section Abstract Doc Link 8609570 Disease Relevance 0.68 Pain Relevance 0.23
A kidney biopsy was remarkable for arteriolar subintimal fibrous thickening and fibrin deposition, but no glomerulonephritis.
Regulation (remarkable) of fibrin in thickening associated with fibrosis and renal disease
2) Confidence 0.44 Published 1988 Journal Am. J. Kidney Dis. Section Abstract Doc Link 3041802 Disease Relevance 1.28 Pain Relevance 0.32
In terms of recurrence rate, complications and foreign body sensation, fewer patients were affected in the fibrin group than in the reference population, although the differences were not statistically significant.
Regulation (affected) of fibrin in body associated with ocular injury and recurrence
3) Confidence 0.40 Published 2006 Journal Hernia Section Abstract Doc Link 16554980 Disease Relevance 1.29 Pain Relevance 0.50
The objectives of this study were to evaluate the effect of fibrin glue on pain and bleeding after tonsillectomy.
Regulation (effect) of fibrin associated with pain and hemorrhage
4) Confidence 0.40 Published 1999 Journal Laryngoscope Section Abstract Doc Link 10201758 Disease Relevance 0.62 Pain Relevance 0.36
Effect of modern fibrin glue on bleeding after tonsillectomy and adenoidectomy.
Regulation (Effect) of fibrin associated with hemorrhage
5) Confidence 0.39 Published 2003 Journal Ann. Otol. Rhinol. Laryngol. Section Title Doc Link 12784978 Disease Relevance 0.38 Pain Relevance 0.11
Research in postsurgical adhesion formation and prevention abounds in a variety of avenues of investigation, including: 1) identification on a molecular level of the components involved in adhesiogenesis and their interactions; 2) clarification of the role of fibrin and fibrinolysis in adhesion formation; 3) standardization of design in preclinical and clinical studies of adhesion formation and prevention; 4) delineation of the relationship between adhesion formation and adhesive complications; and 5) elucidation of efficient, site-specific methods of prophylactic drug delivery.
Regulation (role) of fibrin associated with adhesions
6) Confidence 0.39 Published 1997 Journal Eur J Surg Suppl Section Abstract Doc Link 9076453 Disease Relevance 1.03 Pain Relevance 0
The patients showed prolongation of the euglobulin lysis time throughout the study; the fibrin plate lysis area was initially normal but became abnormal within 2 weeks.
Regulation (abnormal) of fibrin
7) Confidence 0.39 Published 1987 Journal Spine Section Abstract Doc Link 2964731 Disease Relevance 0.51 Pain Relevance 0.49
However, a similar number of prospective randomized trials have reported that fibrin sealants are ineffective at preventing seroma formation, decreasing the time to drain removal, or reducing costs in patients undergoing breast procedures [27-30].
Regulation (ineffective) of fibrin associated with seroma
8) Confidence 0.39 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2464595 Disease Relevance 0.56 Pain Relevance 0
The objectives of this study were to evaluate the effect of fibrin glue on pain and bleeding after tonsillectomy.
Regulation (effect) of fibrin associated with pain and hemorrhage
9) Confidence 0.36 Published 2008 Journal Int. J. Pediatr. Otorhinolaryngol. Section Abstract Doc Link 18282613 Disease Relevance 0.64 Pain Relevance 0.45
Absorbable polyglycolic acid sheets and fibrin glue were used to control the air leakage.
Regulation (control) of fibrin
10) Confidence 0.36 Published 1998 Journal Ann. Thorac. Surg. Section Body Doc Link 9564902 Disease Relevance 0.09 Pain Relevance 0
We explored the effect of fibrin glue injection at the site of dural puncture on cerebrospinal fluid (CSF) leakage in a swine model.
Regulation (effect) of fibrin in cerebrospinal fluid
11) Confidence 0.36 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10735796 Disease Relevance 0 Pain Relevance 0.04
At laparoscopic exploration, a chylous leak within the gallbladder fossa was controlled with suture ligation and fibrin glue with immediate resolution of the leak.
Regulation (controlled) of fibrin in suture
12) Confidence 0.36 Published 2006 Journal Am Surg Section Abstract Doc Link 16494185 Disease Relevance 0.34 Pain Relevance 0.09
Primary adhesion of activated platelets, white blood cells and fibrin to the artificial surface of the venous blood inlet from an oxygenator is not affected by the Trillium surface coating under conditions of full systemic heparinization.
Neg (not) Regulation (affected) of fibrin in platelets associated with adhesions
13) Confidence 0.31 Published 2006 Journal Perfusion Section Abstract Doc Link 16817289 Disease Relevance 0.23 Pain Relevance 0.08
Efficacy of fibrin sealant (human) (Evicel) in rhinoplasty: a prospective, randomized, single-blind trial of the use of fibrin sealant in lateral osteotomy.
Regulation (Efficacy) of fibrin in lateral associated with pain
14) Confidence 0.27 Published 2008 Journal Arch Facial Plast Surg Section Title Doc Link 18794413 Disease Relevance 0.18 Pain Relevance 0.19
Treatment with aspirin abolished the CFRs in all dogs and concomitantly reduced the ex vivo thrombus volume by 84% (p less than 0.01) without affecting platelet adhesion and fibrin deposition.
Neg (without) Regulation (affecting) of fibrin in platelet associated with aspirin, adhesions and thrombosis
15) Confidence 0.23 Published 1991 Journal Arterioscler. Thromb. Section Abstract Doc Link 1911705 Disease Relevance 0.82 Pain Relevance 0.24
The efficacy of collagen dermis membrane and fibrin on cultured epidermal graft using an athymic mouse model.
Regulation (efficacy) of fibrin in dermis
16) Confidence 0.18 Published 1999 Journal Ann Plast Surg Section Title Doc Link 10560869 Disease Relevance 0.35 Pain Relevance 0.09
We did not analyze whether the HBO group (for which the histological data were almost identical to those of the HBO plus fibrin group) healed significantly faster than the control or fibrin groups.
Spec (whether) Regulation (control) of fibrin
17) Confidence 0.12 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC3018382 Disease Relevance 0 Pain Relevance 0
Primary adhesion of activated platelets, white blood cells and fibrin to the artificial surface of the venous blood inlet from an oxygenator is not affected by the Trillium surface coating under conditions of full systemic heparinization.
Neg (not) Regulation (affected) of fibrin in white blood cells associated with adhesions
18) Confidence 0.11 Published 2006 Journal Perfusion Section Abstract Doc Link 16817289 Disease Relevance 0.23 Pain Relevance 0.08
Glycation of the fibrinogen molecules is largely responsible for altered fibrin clot features found at elevated glucose levels (10,11).
Regulation (responsible) of fibrin
19) Confidence 0.09 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.83 Pain Relevance 0.04
A short-term increase in glucose levels does not modify fibrin structure, which explains the similar permeability observed in the HG and NG groups.
Neg (not) Regulation (modify) of fibrin
20) Confidence 0.09 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.72 Pain Relevance 0.05

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