INT17492

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ar) enzyme binding (Ar) DNA binding (Ar)
transcription factor binding (Ar) cytoplasm (Ar)
Anatomy Link Frequency
muscles 2
Ar (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 99.16 Very High Very High Very High
Analgesic 1 97.20 Very High Very High Very High
Pain 3 96.94 Very High Very High Very High
nud 3 78.88 Quite High
anesthesia 1 25.00 Low Low
cva 13 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acne 56 85.44 High High
Dyspepsia 3 78.88 Quite High
Pressure And Volume Under Development 4 77.84 Quite High
Gynecomastia 5 75.00 Quite High
Impaired Glucose Tolerance 1 71.80 Quite High
Breast Cancer 1 60.84 Quite High
Thrombophilia 5 58.56 Quite High
Cardiovascular Disease 2 57.64 Quite High
Toxicity 1 40.32 Quite Low
Recurrence 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following unilateral transection of the hypoglossal and facial nerves, hydroxyflutamide, an androgen receptor antagonist, was injected into the tongue muscles to block androgen receptor binding during the period when rats were treated with testosterone.
Negative_regulation (block) of androgen receptor Binding (binding) of in muscles associated with antagonist
1) Confidence 0.59 Published 1991 Journal Neuroreport Section Abstract Doc Link 1912458 Disease Relevance 0 Pain Relevance 0.05
Benign asymptomatic or painful enlargement of the male breast is a common problem, postulated to be due to an increased estrogen/testosterone ration or due to increased estrogenic or decreased androgenic stimulation via estrogen or androgen receptor interactions.
Negative_regulation (decreased) of androgen receptor Binding (interactions) of associated with pain
2) Confidence 0.41 Published 1986 Journal Metab. Clin. Exp. Section Abstract Doc Link 3526085 Disease Relevance 0.20 Pain Relevance 0.19
It blocks endogenous androgens from binding the androgen receptor and is thus anti-androgenic.
Negative_regulation (blocks) of androgen receptor Binding (binding) of
3) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971728 Disease Relevance 0.56 Pain Relevance 0.04

General Comments

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