INT174924

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 3.59
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Smad7) plasma membrane (Smad7) nucleus (Smad7)
intracellular (Smad7) protein complex (Smad7) cytoplasm (Smad7)
Anatomy Link Frequency
chondrocytes 2
Smad7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 12 99.52 Very High Very High Very High
fibrosis 111 97.56 Very High Very High Very High
Bile 40 92.92 High High
Potency 2 81.04 Quite High
addiction 4 76.12 Quite High
Kinase C 168 74.84 Quite High
Osteoarthritis 8 72.72 Quite High
Inflammation 8 63.52 Quite High
cytokine 28 37.28 Quite Low
metalloproteinase 32 16.84 Low Low
Disease Link Frequency Relevance Heat
Injury 39 99.04 Very High Very High Very High
Fibrosis 102 97.56 Very High Very High Very High
Primary Sclerosing Cholangitis 43 96.96 Very High Very High Very High
Pulmonary Fibrosis 4 94.40 High High
Cirrhosis 217 88.00 High High
Hepatitis C Virus Infection 30 87.44 High High
Cancer 14 80.12 Quite High
Chondrocalcinosis 48 74.40 Quite High
Osteoarthritis 8 72.72 Quite High
Repression 8 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of Smad7, a natural antagonist of TGF-?
Gene_expression (Overexpression) of Smad7 associated with antagonist
1) Confidence 0.41 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC270053 Disease Relevance 0.86 Pain Relevance 0.45
Impressively, overexpression of antagonistic Smad7, a natural antagonist of TGF-?
Gene_expression (overexpression) of Smad7 associated with antagonist
2) Confidence 0.35 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC270053 Disease Relevance 0.94 Pain Relevance 0.33
Based on recently published data on HSC biology [66], it can be hypothesized that Smad7, a negative regulator of TGF-?
Spec (hypothesized) Gene_expression (hypothesized) of Smad7
3) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.46 Pain Relevance 0.03
-RI phosphorylation (28). 0.5 mM NIM811 enhanced the expression of Smad7 nearly two-fold (Fig. 7A) and it suppressed that of TGF-?
Gene_expression (expression) of Smad7
4) Confidence 0.20 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.30 Pain Relevance 0
Next, we evaluated the expression of Smad7, which negatively regulates TGF-?
Gene_expression (expression) of Smad7
5) Confidence 0.20 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.38 Pain Relevance 0
We found that NIM811 enhanced the expression of Smad7, and suppressed that of TGF-?
Gene_expression (expression) of Smad7
6) Confidence 0.20 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.14 Pain Relevance 0
However, we demonstrated that overexpression of wild-type Smad 7 failed to reduce TGF-?
Gene_expression (overexpression) of wild-type Smad 7
7) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.25 Pain Relevance 0.43
1 was affected by overexpression of Smad 7 in chondrocytes (Figure 7b).
Gene_expression (overexpression) of Smad 7 in chondrocytes
8) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.14 Pain Relevance 0.04
Scharstuhl and colleagues [42] demonstrated that Smad 7 overexpression was able to counteract TGF-?
Gene_expression (overexpression) of Smad 7
9) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.12 Pain Relevance 0.49
In chondrocytes transfected to overexpress wild-type Smad 7, an inhibitory Smad, control experiments showed that the basal expression of aggrecan, chosen as a specific Smad-dependent gene in chondrocytes, was reduced marginally (Figure 7a).
Gene_expression (overexpress) of wild-type Smad 7 in chondrocytes
10) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0

General Comments

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