INT17493

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 3.62
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ar) enzyme binding (Ar) DNA binding (Ar)
transcription factor binding (Ar) cytoplasm (Ar)
Anatomy Link Frequency
muscles 1
brain 1
neural 1
Ar (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 2 99.90 Very High Very High Very High
antagonist 9 99.04 Very High Very High Very High
Analgesic 1 97.20 Very High Very High Very High
Pain 10 95.96 Very High Very High Very High
nud 6 78.88 Quite High
Neurobehavioral 19 76.40 Quite High
alcohol 16 74.36 Quite High
depression 7 73.36 Quite High
headache 4 72.40 Quite High
agonist 4 59.36 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 174 99.82 Very High Very High Very High
Acne 112 98.16 Very High Very High Very High
Breast Cancer 32 92.68 High High
Endometriosis (extended) 10 86.00 High High
Aging 3 84.48 Quite High
Cognitive Disorder 29 80.08 Quite High
Dyspepsia 6 78.88 Quite High
Pressure And Volume Under Development 23 77.84 Quite High
Gynecomastia 5 75.00 Quite High
Sleep Disorders 3 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following unilateral transection of the hypoglossal and facial nerves, hydroxyflutamide, an androgen receptor antagonist, was injected into the tongue muscles to block androgen receptor binding during the period when rats were treated with testosterone.
androgen receptor Binding (binding) of in muscles associated with antagonist
1) Confidence 0.48 Published 1991 Journal Neuroreport Section Abstract Doc Link 1912458 Disease Relevance 0 Pain Relevance 0.05
Benign asymptomatic or painful enlargement of the male breast is a common problem, postulated to be due to an increased estrogen/testosterone ration or due to increased estrogenic or decreased androgenic stimulation via estrogen or androgen receptor interactions.
androgen receptor Binding (interactions) of associated with pain
2) Confidence 0.45 Published 1986 Journal Metab. Clin. Exp. Section Abstract Doc Link 3526085 Disease Relevance 0.20 Pain Relevance 0.19
Serum DHT has a higher affinity for the androgen receptor than testosterone [13].
androgen receptor Binding (affinity) of
3) Confidence 0.37 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1403759 Disease Relevance 0.52 Pain Relevance 0
Nonetheless, the ability of flutamide to penetrate the blood brain barrier [8], its relatively pure antiandrogenic activity [5], and its similar affinities for the androgen receptor in various androgen-sensitive tissues [14], make this drug a useful agent in investigating the role of the central and peripheral androgen receptor in androgen-mediated responses.
androgen receptor Binding (affinities) of in brain
4) Confidence 0.35 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1403759 Disease Relevance 0.22 Pain Relevance 0.06
Androgen depletion (3 weeks), and androgen receptor blockade (20–24 h), were implemented to test the hypothesis that testosterone influences baroreflex bradycardia via its activity at the androgen receptor in male rats.
androgen receptor Binding (activity) of associated with heart rate under development
5) Confidence 0.35 Published 2006 Journal BMC Pharmacol Section Abstract Doc Link PMC1403759 Disease Relevance 0.67 Pain Relevance 0
Androgens are defined as the steroids having a binding affinity of the androgen receptor.
androgen receptor Binding (affinity) of
6) Confidence 0.31 Published 2005 Journal Endokrynol Pol Section Abstract Doc Link 16821229 Disease Relevance 0.09 Pain Relevance 0
Androgenic action is determined by quantitative level of the androgen present in the circulation, its degree of binding to proteins, the degree of interconversion to other androgens and estrogens, and the biological potency and androgen receptor binding affinity of the androgen.
androgen receptor Binding (affinity) of associated with potency
7) Confidence 0.20 Published 2005 Journal Endokrynol Pol Section Abstract Doc Link 16821229 Disease Relevance 0.42 Pain Relevance 0.16
Further, some studies suggest that tamoxifen may directly bind the androgen receptor and can inhibit androgen receptor activity [58,59].
androgen receptor Binding (bind) of
8) Confidence 0.16 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.09 Pain Relevance 0
The following bioactivities of E. ulmoides were found: (1) a phenomenal tripartite synergism exists between the sex steroid receptors (androgen and estrogen receptors), their cognate steroidal ligands and lipidic augmenters isolated from E. ulmoides, (2) phytoandrogenic activity of E. ulmoides was mediated by plant triterpenoids binding cognately to the androgen receptor (AR) ligand binding domain.


androgen receptor Binding (binding) of
9) Confidence 0.06 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1797194 Disease Relevance 0 Pain Relevance 0
But none has been previously shown to have corresponding male hormone-like effects that interact with the human androgen receptor.
androgen receptor Binding (interact) of
10) Confidence 0.05 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1797194 Disease Relevance 0 Pain Relevance 0
Third, estrogen administration increases sex hormone binding globulin, which binds serum testosterone, decreasing the amount of free testosterone available to bind with the androgen receptor.15 The efficacy of cOCPs in the treatment of acne is felt to be secondary to these estrogenic effects.
androgen receptor Binding (bind) of associated with acne
11) Confidence 0.01 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971728 Disease Relevance 0.15 Pain Relevance 0
It blocks endogenous androgens from binding the androgen receptor and is thus anti-androgenic.
androgen receptor Binding (binding) of
12) Confidence 0.01 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971728 Disease Relevance 0.55 Pain Relevance 0.04
They bind to androgen and estrogen receptors and can injure the activity of thyroidal hormones, which play a significant role in neurodevelopmental processes such as timing of neural and glial proliferation, migration and differentiation, myelination, synaptic connectivity, development of dopaminergic and cholinergic system (Figueredo et al., 1993; Sawin et al., 1998; Auso et al., 2004;).
androgen Binding (bind) of in neural
13) Confidence 0.01 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984125 Disease Relevance 0.50 Pain Relevance 0.10
The increase in SHBG should lower the serum levels of free testosterone and estradiol, and might be a factor in the reduction in LNCaP cell growth observed following diet and exercise as this cell line is androgen dependent and has a mutated androgen receptor that binds both testosterone and estradiol.
androgen receptor Binding (binds) of
14) Confidence 0.01 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538507 Disease Relevance 0.21 Pain Relevance 0

General Comments

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