INT174958

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 8.73
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Anatomy Link Frequency
hepatocytes 1
MEFs 1
blood cells 1
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 36 99.40 Very High Very High Very High
antagonist 28 98.96 Very High Very High Very High
Inflammation 327 98.52 Very High Very High Very High
Peripheral nerve injury 9 97.88 Very High Very High Very High
Bioavailability 7 96.24 Very High Very High Very High
Arthritis 46 95.68 Very High Very High Very High
cytokine 247 94.88 High High
allodynia 9 93.28 High High
aspirin 7 84.60 Quite High
Inflammatory response 44 84.56 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 52 99.84 Very High Very High Very High
Sepsis 82 99.48 Very High Very High Very High
INFLAMMATION 394 98.52 Very High Very High Very High
Cv General 2 Under Development 66 98.28 Very High Very High Very High
Nervous System Injury 15 97.88 Very High Very High Very High
Fever 146 97.62 Very High Very High Very High
Hepatocellular Cancer 97 96.88 Very High Very High Very High
Cancer 297 96.40 Very High Very High Very High
Disease 67 96.04 Very High Very High Very High
Arthritis 27 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, hepatocytes and blood cells, including Kupffer cells, which are liver macrophages, were used in a carcinogenesis model of IKK?
Negative_regulation (model) of IKK in blood cells
1) Confidence 0.25 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.18 Pain Relevance 0.11
On the other hand, inhibition of the IKK?
Negative_regulation (inhibition) of IKK
2) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.19 Pain Relevance 0.04
In contrast, there was only a small (15%) reduction of IKK?
Negative_regulation (reduction) of IKK
3) Confidence 0.14 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
In previous studies we demonstrated that chemical manipulation in DCs through inhibition of IKK, which is responsible for CD40 upregulation in DC, can result in generation of antigen-specific immune regulation and suppression of pathology in the CIA model [15].
Negative_regulation (inhibition) of IKK associated with arthritis
4) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.56 Pain Relevance 0.24
In keeping with our hypothesis, both pharmacological and dominant negative molecular inhibitions of the IKK?
Negative_regulation (inhibitions) of IKK
5) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.14 Pain Relevance 0.03
in the activation loop (Figure 8), thereby downregulating the activity of the IKK complex.
Negative_regulation (downregulating) of IKK
6) Confidence 0.11 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
These findings suggest a possible effect of B14 on the IKK activity.
Spec (possible) Negative_regulation (effect) of IKK
7) Confidence 0.11 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.09 Pain Relevance 0
peptide was reduced in the presence of B14, indicating B14 inhibited IKK activity (Figure 6).
Negative_regulation (inhibited) of IKK
8) Confidence 0.11 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.20 Pain Relevance 0
To identify which of the IKK components interacts with B14, mouse embryo fibroblasts (MEFs) lacking IKK?
Negative_regulation (lacking) of IKK in MEFs
9) Confidence 0.11 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.06 Pain Relevance 0
In summary, VACV virulence factor B14 inhibits the IKK signalosome by preventing phosphorylation of IKK?
Negative_regulation (inhibits) of IKK
10) Confidence 0.11 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.23 Pain Relevance 0.07
is the target of B14 in the complex and B14 did not bind to or disrupt the IKK?
Neg (not) Negative_regulation (disrupt) of IKK
11) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.06 Pain Relevance 0
Another NSAID, sulindac, has been shown to decrease IKK?
Negative_regulation (decrease) of IKK associated with cinod
12) Confidence 0.09 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.20 Pain Relevance 0.38
B activation [55] through targeted inhibition of IKK [56].
Negative_regulation (inhibition) of IKK
13) Confidence 0.09 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 0.44 Pain Relevance 0.15
Compound 6 was a poor inhibitor of IKK1 with IC50?
Negative_regulation (inhibitor) of IKK1
14) Confidence 0.09 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.16 Pain Relevance 0.11
Accordingly, hepatocytes and blood cells, including Kupffer cells, which are liver macrophages, were used in a carcinogenesis model of IKK?
Negative_regulation (model) of IKK in hepatocytes
15) Confidence 0.08 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.18 Pain Relevance 0.11
B, IFN interferon gamma, IKK inhibitor of NF?
Negative_regulation (inhibitor) of IKK
16) Confidence 0.06 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.14 Pain Relevance 0
B converges at the inhibitor of kappa B kinase (IKK) complex [42].
Negative_regulation (inhibitor) of kappa B kinase
17) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.49 Pain Relevance 0.31
This group clearly demonstrates that antitumor and anti-inflammatory activities assigned to butein may be mediated in part through the direct inhibition of IKK, leading to the suppression of the NF?
Negative_regulation (inhibition) of IKK associated with inflammation
18) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.54 Pain Relevance 0.16
A more promising approach is based on the use of orally active, small-molecule IKK inhibitors including SPC600839 and BMS345541.
Negative_regulation (inhibitors) of IKK
19) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.58 Pain Relevance 0.29
B decoy, inhibitor for IkappaB kinase (IKK), or a TNF?
Negative_regulation (inhibitor) of IKK
20) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.68 Pain Relevance 0.70

General Comments

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