INT17496

Context Info Confidence 0.60 First Reported 1985 Last Reported 2010 Negated 3 Speculated 2 Reported most in Abstract Documents 7 Total Number 9 Disease Relevance 6.49 Pain Relevance 3.62

mitochondrion (Maob) oxidoreductase activity (Maob)

Anatomy Link Frequency brain 2 Maob (Mus musculus)

Pain Link Frequency Relevance Heat monoamine 20 100.00 Dopamine 5 100.00 narcan 2 99.52 aspirin 13 99.30 antidepressant 8 98.16 Enkephalin 11 97.16 imagery 16 96.48 fluoxetine 2 95.72 Analgesic 7 95.08 dexamethasone 1 92.56

Disease Link Frequency Relevance Heat INFLAMMATION 17 100.00 Disease 166 99.90 Nicotine Addiction 342 99.54 Parkinson's Disease 16 99.40 Alagille Syndrome 8 95.20 Cognitive Disorder 14 92.04 Cardiovascular Disorder Under Development 4 90.96 Body Weight 1 90.52 Alzheimer's Dementia 11 90.08 Pathologic Processes 2 88.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present study supports these conclusions and proposes a mechanism regulating MAO-B inhibition and slow recovery.

Spec (proposes) Regulation (regulating) of MAO-B

1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.22 Pain Relevance 0.04

Aspirin or salicylate (100 microM) had no effect on dopamine uptake into striatal synaptosomes or on monoamine oxidase B activity.

Neg (no) Regulation (effect) of monoamine oxidase B associated with aspirin, dopamine and monoamine

2) Confidence 0.50 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9751197 Disease Relevance 0.22 Pain Relevance 0.71

These effects of MPTP were effectively antagonized by prior naloxone treatment but remained unaffected after the MAO-B inhibitor deprenyl.

Neg (unaffected) Regulation (unaffected) of MAO-B associated with parkinson's disease and narcan

3) Confidence 0.43 Published 1991 Journal Neuroreport Section Abstract Doc Link 1912478 Disease Relevance 0.45 Pain Relevance 0.24

It was shown that monoamine oxidase-B (MAO-B) inhibitors and antiinflammatory agents might be effective in treating AD.

Spec (might) Regulation (effective) of monoamine oxidase-B associated with inflammation, disease and monoamine

4) Confidence 0.38 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17611112 Disease Relevance 0.75 Pain Relevance 0.16

The effects of these drugs individually and in combination on brain MAO-A and MAO-B activity and 5-HT uptake were also determined ex vivo and were consistent with expected mechanisms of action.

Regulation (effects) of MAO-B in brain

5) Confidence 0.37 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 4080761 Disease Relevance 0.92 Pain Relevance 0.19

[Effects of monoamine oxidase B inhibitor and MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) on enkephalin levels in mice].

Regulation ([Effects) of monoamine oxidase B associated with parkinson's disease, enkephalin and monoamine

6) Confidence 0.25 Published 1990 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Title Doc Link 2118063 Disease Relevance 0.52 Pain Relevance 0.96

We found that smoking induced an epigenetic regulation of MAOB, i.e. a reduction of its gene promoter methylation, resulting in high MAO protein concentrations which persist long after (over 10 years) quitting smoking.

Regulation (regulation) of MAOB associated with nicotine addiction

7) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.32 Pain Relevance 0.23

For example, using inhibitors of monoamine oxidase B as radiotracers in AD has targeted the elevation of monoamine oxidase B activity [39, 40].

Regulation (targeted) of monoamine oxidase B associated with disease and monoamine

8) Confidence 0.16 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.08 Pain Relevance 0.35

Bis selenide did not alter Na(+) K(+) ATPase, MAO-A and MAO-B activities in whole brains of mice.

Neg (not) Regulation (alter) of MAO-B in brains

9) Confidence 0.08 Published 2010 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19961893 Disease Relevance 0 Pain Relevance 0.74

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