INT174977

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.63
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNFRSF25) signal transduction (TNFRSF25) extracellular region (TNFRSF25)
plasma membrane (TNFRSF25)
Anatomy Link Frequency
cardiomyocytes 1
TNFRSF25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 94 98.12 Very High Very High Very High
cytokine 44 93.00 High High
COX-2 inhibitor 52 89.08 High High
diclofenac 1 56.68 Quite High
fibrosis 19 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 147 100.00 Very High Very High Very High
Apoptosis 254 98.68 Very High Very High Very High
Teratoma 1 98.56 Very High Very High Very High
INFLAMMATION 105 98.12 Very High Very High Very High
Colon Cancer 23 94.00 High High
Necrosis 22 93.96 High High
Cancer 135 93.60 High High
Rheumatoid Arthritis 20 76.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 65.84 Quite High
Adenocarcinoma 5 65.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and a mediator of apoptosis and regulator of inflammation, and TNFRSF4 were downregulated after 1 h infusion of L. plantarum, whereas the TNF receptor TNFRSF25 (DR3) was upregulated after the 1-h exposure to L. plantarum WCFS1.
Positive_regulation (upregulated) of DR3 associated with inflammation and apoptosis
1) Confidence 0.38 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.75 Pain Relevance 0.08
and a mediator of apoptosis and regulator of inflammation, and TNFRSF4 were downregulated after 1 h infusion of L. plantarum, whereas the TNF receptor TNFRSF25 (DR3) was upregulated after the 1-h exposure to L. plantarum WCFS1.
Positive_regulation (upregulated) of TNFRSF25 associated with inflammation and apoptosis
2) Confidence 0.38 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.76 Pain Relevance 0.08
One receptor of the TNF family, TNFRSF25, was upregulated during acute response (1 h exposure).
Positive_regulation (upregulated) of TNFRSF25
3) Confidence 0.38 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.91 Pain Relevance 0.05
Figure 6 shows that although wild-type DREAM causes activation of the DR3- and DR5-containing promoters, DREAM mutants bearing the mutations L47,52V in the first LCD or L155V in the second LCD did not activate basal or ligand-dependent expression of the DR3 and RAR?
Positive_regulation (activation) of DR3
4) Confidence 0.32 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.13 Pain Relevance 0
Carnitine decreases the number of apoptotic cells and lowers caspase 3-like activity in Jurkat T cells after stimulation of the death domain receptor Fas [49], in the serum-starved P19 teratoma cell line [50] and in cardiomyocytes exposed to doxorubicin [51].
Positive_regulation (stimulation) of death domain receptor in cardiomyocytes associated with teratoma, apoptosis and death
5) Confidence 0.03 Published 2003 Journal Crit Care Section Body Doc Link PMC270672 Disease Relevance 0.82 Pain Relevance 0
This effect was due to an accumulation of arachidonic acid inside the cells, which activates sphingomyelinase, triggering a clustering of death receptor (DR) 5 receptors in ceramide and cholesterol-rich domains [119].
Positive_regulation (triggering) of death receptor associated with death
6) Confidence 0.03 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.31 Pain Relevance 0.11
Death receptor activation, ROS, NF-?
Positive_regulation (activation) of Death receptor associated with death
7) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.94 Pain Relevance 0

General Comments

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