INT174979

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 10.11
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
Anatomy Link Frequency
epithelial cells 2
smooth muscle 1
band 1
nucleus 1
apoptotic cell 1
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 577 99.58 Very High Very High Very High
agonist 36 93.92 High High
Inflammation 305 91.36 High High
withdrawal 6 77.88 Quite High
Kinase C 8 20.40 Low Low
Inflammatory mediators 51 5.00 Very Low Very Low Very Low
tolerance 42 5.00 Very Low Very Low Very Low
Inflammatory stimuli 35 5.00 Very Low Very Low Very Low
Serotonin 29 5.00 Very Low Very Low Very Low
imagery 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 307 100.00 Very High Very High Very High
Rheumatoid Arthritis 86 100.00 Very High Very High Very High
Death 37 99.24 Very High Very High Very High
Apoptosis 211 99.02 Very High Very High Very High
Toxicity 14 94.60 High High
Obesity 748 93.96 High High
Carcinoma 64 93.84 High High
Cleidocranial Dysplasia 16 93.28 High High
Metaplasia 32 92.84 High High
Lactic Acidosis 30 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and fluorescent (Fig. 3I,I?)
Phosphorylation (fluorescent) of Fig
1) Confidence 0.51 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0 Pain Relevance 0
Among the abnormal epithelial cells with elevated basal ERK phosphorylation (Fig. 4B), the two cell cultures from metaplastic foci in the airway were distinct because the basal ERK phosphorylation that was equivalent to the OSM-treated control culture (Fig. 5A).
Phosphorylation (phosphorylation) of Fig in epithelial cells
2) Confidence 0.38 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.07 Pain Relevance 0.03
The first aberrancy was the elevated basal or cytokine-stimulated level of phosphorylated ERK (Fig. 4B and 4G, right panel) and the second was the reactivation of LIFR function (Fig. 4D and 4H, right panel).
Phosphorylation (phosphorylated) of Fig associated with cytokine
3) Confidence 0.38 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.28 Pain Relevance 0.12
Among the abnormal epithelial cells with elevated basal ERK phosphorylation (Fig. 4B), the two cell cultures from metaplastic foci in the airway were distinct because the basal ERK phosphorylation that was equivalent to the OSM-treated control culture (Fig. 5A).
Phosphorylation (phosphorylation) of Fig in epithelial cells
4) Confidence 0.38 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.08 Pain Relevance 0.03
The first aberrancy was the elevated basal or cytokine-stimulated level of phosphorylated ERK (Fig. 4B and 4G, right panel) and the second was the reactivation of LIFR function (Fig. 4D and 4H, right panel).
Phosphorylation (phosphorylated) of Fig associated with cytokine
5) Confidence 0.38 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.28 Pain Relevance 0.12
Both inhibitors showed a concentration-dependent reduction of SRP72 phosphorylation (Fig. 4, A and C, *, p < 0.05).
Phosphorylation (phosphorylation) of Fig
6) Confidence 0.34 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
RUA quantification of SRP72 band showed increased phosphorylation peaking at 120 (p < 0.05, Fig. 3B).


Phosphorylation (phosphorylation) of Fig in band
7) Confidence 0.34 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
induced phosphorylation of SRP72 (Fig. 3A, lanes 6–8).
Phosphorylation (phosphorylation) of Fig
8) Confidence 0.34 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
Quantification of the SRP72 phosphorylation confirmed statistically significant reduction of SRP72 serine phosphorylation (Fig. 4, B and D, *, p < 0.05).
Phosphorylation (phosphorylation) of Fig
9) Confidence 0.34 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.05 Pain Relevance 0
Exposure of Granta cells to 30 µM parthenolide for 3 hours resulted in a significant decrease in the phosphorylation state of p65 (Fig. 6B, lane 2) which was abrogated by pretreatment with 5 mM GSH for 2 hours (Fig. 6B, lane 4).
Phosphorylation (phosphorylation) of Fig
10) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780735 Disease Relevance 0.12 Pain Relevance 0
Exposure of Granta cells to 30 µM parthenolide for 3 hours resulted in a significant decrease in the phosphorylation state of p65 (Fig. 6B, lane 2) which was abrogated by pretreatment with 5 mM GSH for 2 hours (Fig. 6B, lane 4).
Phosphorylation (phosphorylation) of Fig
11) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780735 Disease Relevance 0.12 Pain Relevance 0
B phosphorylation in mutated PTEN RL 95-2 and Ishikawa cells (Fig. 2).
Phosphorylation (phosphorylation) of Fig
12) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.38 Pain Relevance 0
These inhibitors dramatically reduced the SRP72 phosphorylation in a concentration-dependent manner (Fig. 3, C and E, respectively).
Phosphorylation (phosphorylation) of Fig
13) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
Stretch of human myometrial smooth muscle significantly increases the interaction (directly, or indirectly within a macromolecular protein complex) between SmAV and tyrosine phosphorylated proteins (Fig. 8A).
Phosphorylation (phosphorylated) of Fig in smooth muscle
14) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.07 Pain Relevance 0
B phosphorylation (Fig. 5).
Phosphorylation (phosphorylation) of Fig
15) Confidence 0.21 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.26 Pain Relevance 0
Moreover, the prostacyclin analogue Cicaprost significantly impaired Rho activation (Fig. 9C) and cofilin phosphorylation (Fig. 9D) in 1° h.AoSMCs pre-treated with siRNATP?
Phosphorylation (phosphorylation) of Fig
16) Confidence 0.19 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Stimulation of 1° h.AoSMCs also led to rapid F-actin polymerization (Fig. 6B) and cofilin phosphorylation with optimal responses generated using 1 ?
Phosphorylation (phosphorylation) of Fig
17) Confidence 0.19 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.11
By 5–15 minutes after the onset of stretch, CaD phosphorylation, normalized for total CaD protein, significantly increased (Fig. 2A).
Phosphorylation (phosphorylation) of Fig
18) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
However, acute stretch did cause a significant increase in FAK-Y925 phosphorylation (Fig. 5A, bottom) perhaps mimicking events that occur later in vivo during the switch to initiate labor.
Phosphorylation (phosphorylation) of Fig
19) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.22 Pain Relevance 0
Matching our results from the GFP-lamin experiments (Fig. 3A and 3B), the alpha-herpesvirus CHPKs were unable to induce serine-22 phosphorylation (Fig. 3C and 3F), whereas the beta- (Figure 3D and 3F) and gamma-herpesvirus CHPKs (Fig. 3E and 3F) did induce serine-22 phosphorylation.
Phosphorylation (phosphorylation) of Fig
20) Confidence 0.18 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0 Pain Relevance 0

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