INT175002

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.70
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) cytoplasm (Mki67)
Anatomy Link Frequency
myocardium 1
hepatocyte 1
livers 1
striatum 1
Mki67 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 47 90.84 High High
fibrosis 3 85.96 High High
Hippocampus 2 78.32 Quite High
ischemia 24 74.00 Quite High
cva 1 54.36 Quite High
positron emission tomography 25 42.64 Quite Low
Pain 8 18.32 Low Low
Calcitonin gene-related peptide 4 13.36 Low Low
palliative 2 10.60 Low Low
substance P 1 9.92 Low Low
Disease Link Frequency Relevance Heat
Cancer 336 100.00 Very High Very High Very High
Triple Negative Breast Cancer 15 98.88 Very High Very High Very High
Hyperplasia 42 98.64 Very High Very High Very High
Osteogenic Sarcomas 30 98.20 Very High Very High Very High
Granular Cell Tumor 24 95.68 Very High Very High Very High
Malignant Neoplastic Disease 45 95.60 Very High Very High Very High
Endometriosis (extended) 2 95.48 Very High Very High Very High
Necrosis 4 94.64 High High
Polycystic Ovary Syndrome 3 93.68 High High
Hepatitis 7 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, once these livers became neoplastic, there was a great increase in the number of Ki67-positive cells (Figure 5G and 5K versus 5H and 5L).


Positive_regulation (increase) of Ki67 in livers
1) Confidence 0.31 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.21 Pain Relevance 0
Indeed, there was evidence for increased hepatocyte proliferation in the MYC-induced neonatal tumor, as demonstrated by an increase in Ki67-positive cells (Figure 4G and 4I versus 4F and 4H).
Positive_regulation (increase) of Ki67 in hepatocyte associated with cancer
2) Confidence 0.31 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.49 Pain Relevance 0
In addition to the histologic features, upregulation of p53 as well as Ki67, a nuclear proliferative marker, has been recently found to correlate with an aggressive clinical course and malignant behavior.
Positive_regulation (upregulation) of Ki67 associated with malignant neoplastic disease
3) Confidence 0.23 Published 2003 Journal World J Surg Oncol Section Body Doc Link PMC272934 Disease Relevance 1.11 Pain Relevance 0
In nestin-EGFP mice, greater numbers of nestin-EGFP+ cells were also Ki67+ over the striatum and penumbral region in EPO+G-CSF-treated mice than in other treatment and control groups (each group n?
Positive_regulation (also) of Ki67 in striatum
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.15 Pain Relevance 0.08
Pyrvinium treatment led to increased Ki-67+ staining of cells in the peri-infarct and distal myocardium (Figure 4A and 4B).
Positive_regulation (increased) of Ki-67 in myocardium
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993965 Disease Relevance 0.26 Pain Relevance 0
A trend for high levels of Ki-67 was also observed in triple negative, although it did not reach statistical significance (p = 0.053).
Positive_regulation (levels) of Ki-67
6) Confidence 0.17 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2217558 Disease Relevance 0.45 Pain Relevance 0
Compared to the control group, high levels—though not statistically significant—of glucose transporter-1, HK II, and Ki67 expression were found at the end of treatment in both FDG and FLT groups.
Neg (not) Positive_regulation (levels) of Ki67
7) Confidence 0.14 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.62 Pain Relevance 0.05
The results suggested a mediating effect of p-AKT for the causal relationship between EGFR and Ki-67.
Positive_regulation (effect) of Ki-67
8) Confidence 0.11 Published 2007 Journal Biomarker Insights Section Abstract Doc Link PMC2717822 Disease Relevance 0.49 Pain Relevance 0
Unexpectedly, many cells were positive for both CK20 and Ki-67.All phases of mitosis were visible: prophase (Figure 5a), metaphase (Figure 5b), anaphase (Figure 5c, e) and telophase (Figure 5d, e).
Positive_regulation (positive) of Ki-67
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0 Pain Relevance 0
Ki-67 tumor proliferation index was similarly and markedly elevated in the three animals: in case 1 it was 37.50%, in case 2 it was 37.9%, and in case 3 it was 32.5%.
Positive_regulation (elevated) of Ki-67 associated with cancer
10) Confidence 0.01 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468625 Disease Relevance 1.92 Pain Relevance 0.14

General Comments

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