INT17501

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 70
Total Number 76
Disease Relevance 32.23
Pain Relevance 7.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
platelet 5
plasma 4
monocyte 4
uterine smooth muscle 1
MDMs 1
F2 (Homo sapiens)
F2 - G20210A (1)
Pain Link Frequency Relevance Heat
Angina 39 100.00 Very High Very High Very High
antagonist 139 99.40 Very High Very High Very High
cva 639 99.28 Very High Very High Very High
Paracetamol 3 99.08 Very High Very High Very High
alcohol 11 98.04 Very High Very High Very High
cINOD 14 97.64 Very High Very High Very High
Inflammation 206 97.44 Very High Very High Very High
cytokine 124 96.88 Very High Very High Very High
Osteoarthritis 184 95.72 Very High Very High Very High
Neuropeptide 1 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 224 100.00 Very High Very High Very High
Cardiovascular Disease 127 99.92 Very High Very High Very High
Thromboembolism 28 99.64 Very High Very High Very High
Viral Meningitis 42 99.54 Very High Very High Very High
Purpura 25 99.52 Very High Very High Very High
Gallstones 1 99.52 Very High Very High Very High
Hemorrhage 239 99.38 Very High Very High Very High
Heparin-induced Thrombocytopenia 74 99.20 Very High Very High Very High
Cancer 110 99.16 Very High Very High Very High
Acid Base Imbalance 2 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human pharmacology of thrombin inhibition.
Negative_regulation (inhibition) of thrombin
1) Confidence 0.58 Published 1996 Journal Coron. Artery Dis. Section Title Doc Link 9116934 Disease Relevance 0.38 Pain Relevance 0.13
Argatroban: a synthetic thrombin inhibitor of low relative molecular mass.
Negative_regulation (inhibitor) of thrombin
2) Confidence 0.58 Published 1996 Journal Coron. Artery Dis. Section Title Doc Link 8889361 Disease Relevance 0 Pain Relevance 0.08
The administration of N-acetylcysteine causes a decrease in prothrombin time in patients with paracetamol overdose but without evidence of liver impairment.
Negative_regulation (decrease) of prothrombin in liver associated with paracetamol and overdose
3) Confidence 0.58 Published 2005 Journal Eur J Gastroenterol Hepatol Section Title Doc Link 15647642 Disease Relevance 0.10 Pain Relevance 0.19
Kidney function tests showed significant rises in SGOT (81 +/- 36 U/l), SGPT (150 +/- 110 U/l) and bilirubin (Bil: 15 +/- 5 mmol/l) and decreases in prothrombin activity (PT: 73 +/- 11%) 24 hours after surgery, with later normalization.
Negative_regulation (decreases) of prothrombin in Kidney
4) Confidence 0.57 Published 1993 Journal Rev Esp Anestesiol Reanim Section Body Doc Link 8248606 Disease Relevance 0 Pain Relevance 0
Direct thrombin inhibitors
Negative_regulation (inhibitors) of thrombin
5) Confidence 0.56 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 0.57 Pain Relevance 0.08
Dabigatran is a potent, competitive, reversible direct thrombin inhibitor.
Negative_regulation (inhibitor) of thrombin
6) Confidence 0.56 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 0.34 Pain Relevance 0.06
Our understanding of protease-activated receptors, such as that for thrombin, is modest and the comparative advantages of receptor antagonism versus specific thrombin inhibition are unknown.
Negative_regulation (inhibition) of thrombin
7) Confidence 0.43 Published 1996 Journal Coron. Artery Dis. Section Abstract Doc Link 9116934 Disease Relevance 0.32 Pain Relevance 0.13
Specific thrombin inhibitors have several theoretical advantages over heparin.
Negative_regulation (inhibitors) of thrombin
8) Confidence 0.43 Published 1996 Journal Coron. Artery Dis. Section Abstract Doc Link 9116934 Disease Relevance 0.38 Pain Relevance 0.13
Argatroban is an arginine derivative that is a highly specific thrombin inhibitor.
Negative_regulation (inhibitor) of thrombin
9) Confidence 0.43 Published 1996 Journal Coron. Artery Dis. Section Abstract Doc Link 8889361 Disease Relevance 0 Pain Relevance 0.08
Severe sepsis was defined as sepsis with evidence of organ dysfunction and hypoperfusion, acute alteration of mental status, elevated plasma lactate, unexplained metabolic acidosis (arterial pH <7.3), hypoxaemia, prolonged prothrombin time or a decrease in platelet count >50% or ?
Negative_regulation (decrease) of prothrombin in platelet associated with acid base imbalance and sepsis
10) Confidence 0.42 Published 2010 Journal Crit Care Section Body Doc Link PMC2887140 Disease Relevance 1.50 Pain Relevance 0
However, a prothrombin 20210 defect should be considered in the differential diagnosis of patients with unexplained thrombosis.
Negative_regulation (defect) of prothrombin associated with thrombosis
11) Confidence 0.42 Published 2007 Journal Surg. Today Section Abstract Doc Link 17342369 Disease Relevance 0.83 Pain Relevance 0.06
The first oral direct thrombin inhibitor available for clinical use was ximelagatran.
Negative_regulation (inhibitor) of thrombin
12) Confidence 0.41 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 0.60 Pain Relevance 0.13
Dabigatran etexilate belongs to a new class of direct thrombin inhibitors.
Negative_regulation (inhibitors) of thrombin
13) Confidence 0.41 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2879296 Disease Relevance 1.08 Pain Relevance 0.11
Moreover, the inhibition of thrombin may be the most efficient way of inhibiting coagulation, giving rise to the development of drugs which specifically target it.59 Although it is currently not clear which mechanism will give rise to better clinical outcomes, both FXa and thrombin are likely to be excellent targets for inhibition with new anticoagulant drugs.
Negative_regulation (inhibition) of thrombin
14) Confidence 0.41 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 0.43 Pain Relevance 0.13
The fact that tcu-PA/T could not be detected in the other three groups was explained by a lower extent of thrombin generation, a greater inhibition of thrombin by antithrombin, or less available urokinase antigen in these groups.
Negative_regulation (extent) of thrombin
15) Confidence 0.41 Published 1999 Journal J. Lab. Clin. Med. Section Abstract Doc Link 10444030 Disease Relevance 0.63 Pain Relevance 0.16
Unlike heparin, fondaparinux does not inactivate thrombin or inhibit FXa bound in the prothrombinase complex and therefore does not completely inhibit FXa.
Negative_regulation (inactivate) of thrombin
16) Confidence 0.41 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 0.94 Pain Relevance 0.03
Consequently, thrombin inhibition of bivalirudin inactivates not only fluid-phase thrombin, but also fibrin-bound thrombin [80].
Negative_regulation (inactivates) of thrombin
17) Confidence 0.38 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987921 Disease Relevance 0.36 Pain Relevance 0
Bivalirudin is a bivalent reversible direct thrombin inhibitor and has been used safely for CPB in HIT-positive patients [56,72,74-76].
Negative_regulation (inhibitor) of thrombin associated with heparin-induced thrombocytopenia
18) Confidence 0.38 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987921 Disease Relevance 0.56 Pain Relevance 0.06
All three direct thrombin inhibitors available in the United States-argatroban, bivalirudin, and lepirudin-are pregnancy category B drugs based on animal studies, but little data are available on the safety of these agents during human pregnancy.
Negative_regulation (inhibitors) of thrombin
19) Confidence 0.37 Published 2008 Journal Pharmacotherapy Section Abstract Doc Link 19025434 Disease Relevance 0.39 Pain Relevance 0
Comparative inhibition of LPS-activated human monocyte-induced thrombin generation by unfractionated heparin and low molecular weight heparins.
Negative_regulation (inhibition) of thrombin in monocyte
20) Confidence 0.37 Published 1999 Journal Haemostasis Section Title Doc Link 10844403 Disease Relevance 0 Pain Relevance 0

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