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Context Info
Confidence 0.11
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (S100A6) intracellular (REN) cytoplasm (S100A6)
response to stress (REN) cytosol (S100A6) signal transduction (S100A6)
Anatomy Link Frequency
plasma 2
REN (Homo sapiens)
S100A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 12 88.16 High High
depression 28 83.04 Quite High
agonist 4 60.16 Quite High
dexamethasone 3 59.52 Quite High
antagonist 4 23.20 Low Low
Inflammation 2 6.32 Low Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 44 93.20 High High
Cv Unclassified Under Development 11 88.16 High High
Depression 29 83.04 Quite High
Injury 2 75.16 Quite High
Critical Illness 1 46.12 Quite Low
Adhesions 2 42.12 Quite Low
Hyperemia 8 5.00 Very Low Very Low Very Low
Cushing's Syndrome /


6 5.00 Very Low Very Low Very Low
Hyperaldosteronism 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early studies showed a reduced plasma renin activity (PRA) in depressed patients [30] and an increase in resting PRA accompanied by a blunted renin response to posture in bipolar patients [31].
renin Binding (activity) of PRA in plasma
1) Confidence 0.11 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.45 Pain Relevance 0.28
ACE: Angiotensin converting enzyme; Ang II: plasma concentration of angiotensin II; EDTA: ethylenediaminetetraacetate; NIRS: near infrared spectroscopy; PRA: plasma renin activity; RAS: Renin-Angiotensin System; RIA: radioimmune assay; SOFA: Sequential Organ Failure Assessment score; SpO2: percent oxygen saturation of arterial hemoglobin: as measured with pulse oximetry; StO2: percent oxygen saturation of microvascular (tissue) hemoglobin: as measured with NIRS.

plasma renin Binding (activity) of PRA in plasma
2) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.68 Pain Relevance 0.08

General Comments

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