INT175023

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Context Info
Confidence 0.15
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.84
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR3C2) signal transduction (NR3C2) endoplasmic reticulum (NR3C2)
nucleus (NR3C2) cytoplasm (NR3C2)
NR3C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 90.72 High High
dexamethasone 5 85.32 High High
depression 28 83.20 Quite High
Inflammatory stimuli 10 71.84 Quite High
cytokine 42 69.60 Quite High
Inflammation 51 50.00 Quite Low
agonist 4 23.92 Low Low
COX2 4 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cushing's Syndrome /

Hypercortisolism

6 99.66 Very High Very High Very High
Weight Loss 1 94.68 High High
Graft Vs Host Disease 5 86.48 High High
Depression 29 83.20 Quite High
INFLAMMATION 56 71.52 Quite High
Inflammatory Bowel Disease 21 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 4 5.00 Very Low Very Low Very Low
Hyperaldosteronism 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that the pathophysiology of the hypercortisolism is related to a change in function of mineralocorticoid receptors (MR) (for review see [10], as a block of the MR leads to hypercortisolism in healthy controls [11,12].
Regulation (change) of MR
1) Confidence 0.15 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.40 Pain Relevance 0.24
Both cycling and reagent concentrations for PCR reactions targeting the mcrA gene were according to the methodology of Hales et al., [20].
Regulation (targeting) of mcrA
2) Confidence 0.09 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0 Pain Relevance 0
Drastic suppression of MLR responses was observed with WJMSCs as compared to BMMSCs (p-value 0.01).
Regulation (responses) of MLR
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

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