INT175050

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Etv5) DNA binding (Etv5)
Anatomy Link Frequency
cleft 2
Etv5 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 49.80 Quite Low
Nav1.6 1 25.80 Quite Low
Nav1.2 1 25.00 Low Low
Sciatic nerve 18 20.64 Low Low
Action potential 1 7.68 Low Low
sodium channel 6 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
vagus nerve 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleft Palate 16 99.24 Very High Very High Very High
Targeted Disruption 54 97.44 Very High Very High Very High
Apoptosis 38 65.44 Quite High
Adhesions 8 32.48 Quite Low
Congenital Anomalies 14 5.00 Very Low Very Low Very Low
Ventricular Heart Septal Defects 8 5.00 Very Low Very Low Very Low
Persistent Truncus Arteriosus 8 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERM proteins are regulated cytoplasmic cross-linkers between actin cytoskeleton and transmembrane proteins [15], and cannot mediate direct nodal axoglial contacts.
Regulation (regulated) of ERM
1) Confidence 0.60 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC293377 Disease Relevance 0 Pain Relevance 0
Mice carrying a large deletion of chromosome 14 (Pub36-/-), a region that contains the Spry2 gene exhibit cleft palate, excessive cell proliferation and up regulation of FGF target genes including Msx1, Etv5 and Barx1 [19].
Regulation (regulation) of Etv5 in cleft associated with cleft palate
2) Confidence 0.52 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.44 Pain Relevance 0
Mice carrying a large deletion of chromosome 14 (Pub36-/-), a region that contains the Spry2 gene exhibit cleft palate, excessive cell proliferation and up regulation of FGF target genes including Msx1, Etv5 and Barx1 [19].
Regulation (target) of Etv5 in cleft associated with cleft palate
3) Confidence 0.23 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.44 Pain Relevance 0

General Comments

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