INT175093

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2003
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 1.84
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LCN6)
Anatomy Link Frequency
efferent ducts 3
sperm 3
corpus 2
testis 2
epididymis 2
LCN6 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 38 93.96 High High
Analgesic 19 63.40 Quite High
imagery 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonal Carcinoma 57 91.76 High High
Cancer 19 88.16 High High
Apoptosis 38 84.64 Quite High
Reprotox - General 1 19 77.24 Quite High
Bacterial Respiratory Disease 38 73.92 Quite High
Body Weight 19 37.92 Quite Low
Dissociative Disorders 19 35.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However many of these fail to encode LCN6 either because they are splicing variants or they originate from the 3', nonLCN6 half of this locus and thus do not indicate LCN6 expression in those tissues.
Gene_expression (expression) of LCN6
1) Confidence 0.77 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.09 Pain Relevance 0.04
Expression of LCN6 in distal efferent ducts and caput epididymis and localization of the protein on the surface of spermatozoa are consistent with a role in spermatozoa maturation.
Gene_expression (Expression) of LCN6 in efferent ducts
2) Confidence 0.67 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.07 Pain Relevance 0.05
-barrel structure of LCN6 closely matches that of Mup1, however the relatively short C-terminus of human LCN6 lacks the region that in Mup1 contains the cysteine that forms a disulfide bond with a cysteine in the ?
Gene_expression (matches) of LCN6
3) Confidence 0.67 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0 Pain Relevance 0
To determine whether LCN6 expression is predominantly in the epididymis as reported for Lcn5 and Lcn8, total RNAs from epididymis and 25 other human tissues and 4 cell lines were analyzed by Northern blot hybridization (Fig. 5).
Spec (whether) Gene_expression (expression) of LCN6 in epididymis
4) Confidence 0.67 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.05 Pain Relevance 0.03
Recombinant human LCN6 protein used to raise antibody in rabbit
Gene_expression (protein) of LCN6
5) Confidence 0.67 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.17 Pain Relevance 0.06
The cDNA corresponding to the mature human LCN6 protein (Val21 to stop) was amplified by PCR from a human caput/corpus cDNA library [27] constructed in ?
Gene_expression (stop) of LCN6 in corpus
6) Confidence 0.67 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.16 Pain Relevance 0.06
From more than 130 clones obtained, a cDNA encoding a novel lipocalin, LCN6 was selected for analysis in part because of its close relationship to two well studied rodent epididymal lipocalins, Lcn5 and Lcn8.
Gene_expression (selected) of LCN6
7) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0 Pain Relevance 0
Regional differences in expression site and differences in the influence of the testis on expression of Lcn5, Lcn8 and LCN6 may be factors driving the evolutionary maintenance in rodent and human of this gene cluster that is derived by gene duplication [9].
Gene_expression (expression) of LCN6 in testis
8) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.18 Pain Relevance 0
The LCN6 expression in distal efferent ducts, initial segment and proximal caput is similar to that of rat Lcn5 [66] and mouse Lcn8 [67] but differs from the mouse Lcn5 which is expressed in distal caput and corpus and accumulates in caudal fluid [4,26].
Gene_expression (expression) of LCN6 in efferent ducts
9) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.16 Pain Relevance 0
The LCN6 expression in distal efferent ducts, initial segment and proximal caput is similar to that of rat Lcn5 [66] and mouse Lcn8 [67] but differs from the mouse Lcn5 which is expressed in distal caput and corpus and accumulates in caudal fluid [4,26].
Gene_expression (expressed) of Lcn5 in corpus
10) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.15 Pain Relevance 0
The lack of androgen regulation of LCN6 expression may reflect functions apart from sperm maturation such as maintenance of healthy epididymal epithelium under changing physiological conditions.
Gene_expression (expression) of LCN6 in sperm
11) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.13 Pain Relevance 0
We show that LCN6 expression is highly epididymis-specific, but appears to be regulated little if at all by androgen but may be regulated by testis factors in corpus.
Gene_expression (expression) of LCN6 in epididymis
12) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.06 Pain Relevance 0
The LCN6 expression in distal efferent ducts, initial segment and proximal caput is similar to that of rat Lcn5 [66] and mouse Lcn8 [67] but differs from the mouse Lcn5 which is expressed in distal caput and corpus and accumulates in caudal fluid [4,26].
Gene_expression (expression) of Lcn5 in efferent ducts
13) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.16 Pain Relevance 0
LCN6 is also present in the lumen in association with spermatozoa, consistent with secretion from epithelial cells as suggested by the presence of a predicted hydrophobic signal peptide.
Gene_expression (present) of LCN6 in epithelial cells
14) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0 Pain Relevance 0
Labeling of human ejaculate spermatozoa with affinity-purified anti-LCN6 demonstrated that LCN6 was present on all spermatozoa (Fig. 8).
Gene_expression (present) of LCN6 in spermatozoa
15) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0 Pain Relevance 0
Regional differences in expression site and differences in the influence of the testis on expression of Lcn5, Lcn8 and LCN6 may be factors driving the evolutionary maintenance in rodent and human of this gene cluster that is derived by gene duplication [9].
Gene_expression (expression) of Lcn5 in testis
16) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.18 Pain Relevance 0
The more distal expression of mouse Lcn5 positions it to affect sperm maturation downstream of where Lcn8 becomes available to spermatozoa in the lumen.
Gene_expression (expression) of Lcn5 in sperm
17) Confidence 0.60 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.14 Pain Relevance 0
Separate orthologs of LCN6 and of the adjacent gene are predicted in mouse and rat and we isolated the rat Lcn6 as an independently expressed sequence (data not shown).
Neg (independently) Gene_expression (expressed) of Lcn6
18) Confidence 0.58 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.09 Pain Relevance 0.03
Expression of LCN6 in distal efferent ducts and caput epididymis and localization of the protein on the surface of spermatozoa are consistent with a role in spermatozoa maturation.
Gene_expression (Expression) of LCN6 in caput epididymis
19) Confidence 0.23 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.07 Pain Relevance 0.05

General Comments

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