INT175098

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LCN1)
Anatomy Link Frequency
internal 1
LCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 30 40.40 Quite Low
Inflammation 33 5.00 Very Low Very Low Very Low
Multiple sclerosis 26 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
COX2 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Demyelination 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonal Carcinoma 6 98.64 Very High Very High Very High
Apoptosis 6 98.22 Very High Very High Very High
Multiple Sclerosis 132 50.00 Quite Low
Stress 77 50.00 Quite Low
Urological Neuroanatomy 10 45.52 Quite Low
INFLAMMATION 36 5.00 Very Low Very Low Very Low
Disease 23 5.00 Very Low Very Low Very Low
Central Nervous System Disease 9 5.00 Very Low Very Low Very Low
Paralysis 6 5.00 Very Low Very Low Very Low
Demyelinating Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cellular responses were demonstrated for 24p3/Lcn2 protein which induced apoptosis by a receptor-mediated pathway in murine FL5.12 l2 pro-B lymphocytic cell line [64] and Lcn-1 was internalized after binding a specific receptor on human NT2 embryonal carcinoma cells [65].
Lcn-1 Binding (binding) of associated with embryonal carcinoma and apoptosis
1) Confidence 0.37 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.20 Pain Relevance 0
Whether internal responses are generated in spermatozoa after lipocalin binding has not been reported.
lipocalin Binding (binding) of in internal
2) Confidence 0.37 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.19 Pain Relevance 0
The dilution of the antibody was 1:1000 in TBS-Tween; (c) myelin basic protein (MBP) rabbit polyclonal antibody from Santa Cruz Biotechnology (Santa Cruz, CA, USA) raised against amino acids 134-304 (deletion 193-218) of MBP of human origin in a dilution of 1:1000 in TBS-tween; (d) NOS-2 rabbit polyclonal antibody from Santa Cruz Biotechnology raised against a peptide mapping at the amino terminus of NOS-2 of human origin in a dilution of 1:1000 in TBS-Tween; (e) COX-2 goat polyclonal antibody from Santa Cruz Biotechnology raised against a peptide mapping at the C-terminus of COX-2 of human origin in a dilution of 1:750 in 5% skim milk in TBS-Tween; and (f) lipocalin PGDS rabbit polyclonal antibody from Cayman (Cayman Chemical Europe, Tallinn, Estonia) which recognizes human lipocalin-type PGD synthase amino acids 30-41 (VQPNFQPDKFLG) in a dilution of 1: 500 in 5% skim milk in TBS-Tween.
lipocalin Binding (recognizes) of
3) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 0 Pain Relevance 0

General Comments

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