INT17511

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Context Info
Confidence 0.41
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 12.00
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRTN3) peptidase activity (PRTN3) plasma membrane (PRTN3)
enzyme binding (PRTN3)
Anatomy Link Frequency
plasma 2
neutrophil 2
synovial fluid 1
spinal cord 1
joint 1
PRTN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 21 99.90 Very High Very High Very High
analgesia 2 99.44 Very High Very High Very High
Spinal cord 3 99.20 Very High Very High Very High
Osteoarthritis 20 99.06 Very High Very High Very High
Morphine 2 97.92 Very High Very High Very High
Inflammation 75 97.76 Very High Very High Very High
cva 4 97.20 Very High Very High Very High
corticosteroid 15 97.16 Very High Very High Very High
Multiple sclerosis 68 96.76 Very High Very High Very High
cINOD 6 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Disease 107 99.92 Very High Very High Very High
Creutzfeldt Jakob Disease 20 99.32 Very High Very High Very High
Osteoarthritis 21 99.06 Very High Very High Very High
Dyspnea 3 98.92 Very High Very High Very High
Increased Venous Pressure Under Development 23 98.88 Very High Very High Very High
Hematuria 1 98.44 Very High Very High Very High
Apoptosis 24 98.36 Very High Very High Very High
Odontogenic Tumors 42 98.20 Very High Very High Very High
INFLAMMATION 76 97.76 Very High Very High Very High
Urological Neuroanatomy 4 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While nodular vasculitis is known to occur in Wegener's granulomatosis, to the best of our knowledge, this case represents the first c-ANCA negative primary pulmonary vasculitis in childhood.
Negative_regulation (represents) of c-ANCA associated with increased venous pressure under development
1) Confidence 0.41 Published 2004 Journal Pediatr. Pulmonol. Section Abstract Doc Link 14730665 Disease Relevance 0.58 Pain Relevance 0.07
A recent subtractive cDNA cloning study in rats demonstrated an unexpected increase in expression of the proteinase inhibitor, cystatin C in the spinal cord during acute peripheral inflammation, suggesting this protein may be involved in the pathogenesis of persistent pain.
Negative_regulation (inhibitor) of proteinase in spinal cord associated with pain, inflammation, lasting pain and spinal cord
2) Confidence 0.36 Published 2004 Journal Pain Section Abstract Doc Link 14736582 Disease Relevance 0.65 Pain Relevance 0.65
Blood laboratory results revealed a serum creatinine concentration of 2.1 mg/dL, ethrythrocyte sedimentation rate of 61 mm/hr, negative cANCA (antineutrophil cytoplasmic antibody cytoplasmic pattern), positive pANCA (ANCA perinuclear pattern), and antiglomerular basement membrane negative.
Negative_regulation (revealed) of cANCA in basement membrane
3) Confidence 0.36 Published 2003 Journal Environ Health Perspect Section Abstract Doc Link PMC1241769 Disease Relevance 1.05 Pain Relevance 0.12
Blood investigations revealed haemoglobin (Hb) 9.0 g/dL, white cell count (WCC) 22.15 109/L, platelets (PLT) 522 109/L, CRP 227 mg/L, creatinine 159 umol/L, and positive cytoplasmic pattern anti-neutrophil cytoplasmic antibodies (cANCA) (ANCA protease-3 (PR3) 18 u/ml and ANCA myeloperoxidase (MPO) 1 u/ml).
Negative_regulation (revealed) of cANCA in neutrophil associated with urological neuroanatomy
4) Confidence 0.27 Published 2008 Journal Head Face Med Section Body Doc Link PMC2531096 Disease Relevance 0.99 Pain Relevance 0.19
The proteinase responsible for this process was classified as a metal-dependent serine proteinase and was effectively inactivated by phenylmethylsulfonyl fluoride and ethylenediaminetetraacetic acid.
Negative_regulation (inactivated) of proteinase
5) Confidence 0.17 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9537675 Disease Relevance 0.06 Pain Relevance 0.25
The proteinase responsible for this process was classified as a metal-dependent serine proteinase and was effectively inactivated by phenylmethylsulfonyl fluoride and ethylenediaminetetraacetic acid.
Negative_regulation (inactivated) of proteinase
6) Confidence 0.17 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9537675 Disease Relevance 0.06 Pain Relevance 0.26
This large N-terminal midfragment, representing 75-80% of the intact osteocalcin level, is not lower when the plasma assay is performed immediately after sampling (within 20 minutes at 4 degrees C with proteinase inhibitors), indicating that it circulates in vivo.
Negative_regulation (inhibitors) of proteinase in plasma
7) Confidence 0.10 Published 1994 Journal J. Bone Miner. Res. Section Abstract Doc Link 8140939 Disease Relevance 0.93 Pain Relevance 0.08
The tissue factor pathway inhibitor 2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor.
Negative_regulation (inhibitor) of proteinase
8) Confidence 0.07 Published 2006 Journal Cancer Sci. Section Abstract Doc Link 16965396 Disease Relevance 0.67 Pain Relevance 0.10
Heparin cofactor II (HCII) is a serine proteinase inhibitor in human plasma that rapidly inhibits thrombin in the presence of dermatan sulfate or heparin.
Negative_regulation (inhibitor) of proteinase in plasma
9) Confidence 0.06 Published 1996 Journal Blood Section Abstract Doc Link 8562924 Disease Relevance 0.15 Pain Relevance 0.08
However, the combination therapy produced a statistically significant synergistic reduction of collagenase, gelatinase, and serpinolytic (alpha1-PI degrading) activities (69%, 69%, and 75% reductions, respectively) and a lesser reduction of the serine proteinase, elastase (46%).
Negative_regulation (reduction) of proteinase
10) Confidence 0.06 Published 2004 Journal J. Periodontol. Section Body Doc Link 15088884 Disease Relevance 0 Pain Relevance 0
Detection of a proteinase inhibitor, 14-3-3 protein released from damaged neurons into CSF fortifies the diagnosis [3,4].
Negative_regulation (inhibitor) of proteinase in neurons
11) Confidence 0.03 Published 2008 Journal Cases J Section Body Doc Link PMC2547099 Disease Relevance 1.56 Pain Relevance 0.03
Serpin B1 is a leukocyte elastase inhibitor and regulates the activity of the neutrophil proteases elastase, cathepsin G and proteinase-3.
Negative_regulation (inhibitor) of proteinase-3 in neutrophil
12) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.03 Pain Relevance 0.22
and the proteinase inhibitors to be tested.
Negative_regulation (inhibitors) of proteinase
13) Confidence 0.02 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.05 Pain Relevance 0
In animal models of OA, the local or general administration of GAGPS reduces the proteinase activity, the level of uronic acid in synovial fluid and the number of inflammatory cells in synovia.
Negative_regulation (reduces) of proteinase in synovial fluid associated with inflammation and osteoarthritis
14) Confidence 0.02 Published 1991 Journal Drugs Exp Clin Res Section Abstract Doc Link 1914839 Disease Relevance 0.53 Pain Relevance 0.41
Therefore kinin receptor antagonists and proteinase inhibitors may be useful as therapeutic agents.
Negative_regulation (inhibitors) of proteinase associated with antagonist
15) Confidence 0.01 Published 2004 Journal Biol. Chem. Section Abstract Doc Link 15576318 Disease Relevance 0.39 Pain Relevance 0.10
also increases plasminogen activator inhibitor type 2, a serine proteinase inhibitor, which is thought to protect cells from apoptosis.[14] The prevention of apoptosis by this or other mechanisms could lead to increased longevity of keratinocytes and consequently to a thickened epidermis.
Negative_regulation (inhibitor) of proteinase in epidermis associated with aging and apoptosis
16) Confidence 0.01 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.78 Pain Relevance 0.22
It may be necessary to combine proteinase inhibitors, either in sequence or with other agents that hit other specific steps in the pathogenesis, before the chronic cycle of joint destruction found in these diseases can be broken.


Negative_regulation (inhibitors) of proteinase in joint associated with disease
17) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.62 Pain Relevance 0.29
Proteinase inhibitors
Negative_regulation (inhibitors) of Proteinase
18) Confidence 0.01 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.65 Pain Relevance 0.23
Interestingly, Takahashi et al. [21] observed a positive staining for iron-binding proteins (transferring, ferritin) and proteinase inhibitor (alpha-one-antitrypsin) in various cells of AOT indicating their role to the pathogenesis of AOT.
Negative_regulation (inhibitor) of proteinase associated with odontogenic tumors
19) Confidence 0.00 Published 2005 Journal Head Face Med Section Body Doc Link PMC1266042 Disease Relevance 1.27 Pain Relevance 0

General Comments

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